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TP論文オンライン
TP論文オンライン欄は、PubMedより本プログラム参画研究者のEpub情報をRSS入手し、最新の3件を掲示しています。
最新の3件
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Nakashima K, Yamaguchi-Shinozaki K.
ABA signaling in stress-response and seed development.
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Tanaka Y, Hipolito CJ, Maturana AD, Ito K, Kuroda T, Higuchi T, Katoh T, Kato HE, Hattori M, Kumazaki K, Tsukazaki T, Ishitani R, Suga H, Nureki O.
Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.
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Hou Z, Oishi S, Suzuki Y, Kure T, Nakanishi I, Hirasawa A, Tsujimoto G, Ohno H, Fujii N.
Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors.
以前のTP論文オンライン
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Choi SW, Tamaki T, Ebine K, Uemura T, Ueda T, Nakano A.
RABA Members Act in Distinct Steps of Subcellular Trafficking of the FLAGELLIN SENSING2 Receptor.
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Terashima H, Li N, Sakuma M, Koike M, Kojima S, Homma M, Imada K.
Insight into the assembly mechanism in the supramolecular rings of the sodium-driven Vibrio flagellar motor from the structure of FlgT.
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Sangawa T, Tabata S, Suzuki K, Saheki Y, Tanaka K, Takagi J.
A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein.
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Tanaka K, Matsuda N.
Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy.
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Iwai K.
Diverse Roles of the Ubiquitin System in NF-κB Activation.
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Sakoh-Nakatogawa M, Matoba K, Asai E, Kirisako H, Ishii J, Noda NN, Inagaki F, Nakatogawa H, Ohsumi Y.
Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site.
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Niwa H, Handa N, Tomabechi Y, Honda K, Toyama M, Ohsawa N, Shirouzu M, Kagechika H, Hirano T, Umehara T, Yokoyama S.
Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives.
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Taoka K, Ohki I, Tsuji H, Kojima C, Shimamoto K.
Structure and function of florigen and the receptor complex.
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Misu R, Oishi S, Setsuda S, Noguchi T, Kaneda M, Ohno H, Evans B, Navenot JM, Peiper SC, Fujii N.
Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes.
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Shiba T, Kido Y, Sakamoto K, Inaoka DK, Tsuge C, Tatsumi R, Takahashi G, Balogun EO, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Saimoto H, Moore AL, Harada S, Kita K.
Structure of the trypanosome cyanide-insensitive alternative oxidase.
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Muramatsu T, Kim YT, Nishii W, Terada T, Shirouzu M, Yokoyama S.
Autoprocessing mechanism of Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease (SARS-CoV 3CLpro ) from its polyproteins.
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Tsuji H, Taoka K, Shimamoto K.
Florigen in rice: complex gene network for florigen transcription, florigen activation complex, and multiple functions.
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Nakagawa H, Kuratani M, Goto-Ito S, Ito T, Katsura K, Terada T, Shirouzu M, Sekine S, Shigi N, Yokoyama S.
Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA.
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Asano L, Ito I, Kuwabara N, Waku T, Yanagisawa J, Miyachi H, Shimizu T.
Structural basis for vitamin D receptor agonism by novel nonsecosteroidal ligands.
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Kawano K, Yano Y, Omae K, Matsuzaki S, Matsuzaki K.
Stoichiometric Analysis of Oligomerization of Membrane Proteins on Living Cells Using Coiled-coil Labeling and Spectral Imaging.
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Uejima T, Ihara K, Sunada M, Kawasaki M, Ueda T, Kato R, Nakano A,Wakatsuki S.
Direct metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reaction.
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Rahman S, Yamato I, Saijo S, Mizutani K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Iwata S, Murata T.
Biochemical and Biophysical Properties of Interactions between Subunits of the Peripheral Stalk Region of Human V-ATPase.
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Oie S, Matsuzaki K, Yokoyama W, Murayama A, Yanagisawa J.
HDAC3 regulates stability of estrogen receptor α mRNA.
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Nozawa K, Ishitani R, Yoshihisa T, Sato M, Arisaka F, Kanamaru S, Dohmae N, Mangroo D, Senger B, Becker HD, Nureki O.
Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm.
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Osakabe Y, Arinaga N, Umezawa T, Katsura S, Nagamachi K, Tanaka H, Ohiraki H, Yamada K, Seo SU, Abo M, Yoshimura E, Shinozaki K, Yamaguchi-Shinozaki K.
Osmotic Stress Responses and Plant Growth Controlled by Potassium Transporters in Arabidopsis.
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Makide K, Aoki J.
GPR34 as a lysophosphatidylserine receptor.
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Misu R, Noguchi T, Ohno H, Oishi S, Fujii N.
Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists.
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Murayama Y, Sekine S, Yokoyama S.
Crystallization and preliminary X-ray crystallographic analyses of Thermus thermophilus backtracked RNA polymerase.
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Sugiyama M, Sahashi H, Kurimoto E, Takata S, Yagi H, Kanai K, Sakata E, Minami Y, Tanaka K, Kato K.
Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form.
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Nojima S, Toyofuku T, Kamao H, Ishigami C, Kaneko J, Okuno T, Takamatsu H, Ito D, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Ogata A, Ikawa M, Morii E, Aozasa K, Takagi J, Takahashi M, Kumanogoh A.
A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration.
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Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Côté JF, Fukui Y.
Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.
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Ohira T, Suzuki T, Miyauchi K, Suzuki T, Yokobori S, Yamagishi A, Watanabe K.
Decoding mechanism of non-universal genetic codes in Loligo bleekeri mitochondria.
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Otani H, Higo A, Nanamiya H, Horinouchi S, Ohnishi Y.
An alternative sigma factor governs the principal sigma factor in Streptomyces griseus.
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Takaya D, Sato T, Yuki H, Sasaki S, Tanaka A, Yokoyama S, Honma T.
Prediction of ligand-induced structural polymorphism of receptor interaction sites using Machine Learning.
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Futamura Y, Muroi M, Osada H.
Target identification of small molecules based on chemical biology approaches.
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Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T, Higuchi T.
Effect of Helical Conformation and Side-Chain Structure on γ-Secretase Inhibition by β-Peptide Foldamers: Insight into Substrate Recognition.
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Yamauchi T, Kadowaki T.
Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases.
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Zheng H, Miyakawa T, Sawano Y, Yamagoe S, Tanokura M.
Expression, high-pressure refolding and purification of human leukocyte cell-derived chemotaxin 2 (LECT2).
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Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N.
Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182.
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Tsuji H, Nakamura H, Taoka KI, Shimamoto K.
Functional Diversification of FD Transcription Factors in Rice, Components of Florigen Activation Complexes.
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Takatsu H, Katoh Y, Ueda T, Waguri S, Murayama T, Takahashi S, Shin HW, Nakayama K.
Mitosis-coupled, microtubule-dependent clustering of endosomal vesicles around centrosomes.
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Arai S, Saijo S, Suzuki K, Mizutani K, Kakinuma Y, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Iwata S, Yamato I, Murata T.
Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures.
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Yoshikawa K, Nakagawa H, Mori N, Watanabe H, Touhara K.
An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor.
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Momose K, Minami A, Shimono Y, Mizutani K, Nobutani K, Azuma T, Takai Y.
miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling.
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Asad J, Maruyama K, Todaka D, Kidokoro S, Abo M, Yoshimura E, Shinozaki K, Nakashima K, Yamaguchi-Shinozaki K.
OsTZF1, a CCCH-tandem zinc finger protein, confers delayed senescence and stress tolerance in rice by regulating stress-related genes.
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Jounai N, Kobiyama K, Takeshita F, Ishii KJ.
Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination.
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Taniguchi T, Miyauchi K, Nakane D, Miyata M, Muto A, Nishimura S, Suzuki T.
Decoding system for the AUA codon by tRNAIle with the UAU anticodon in Mycoplasma mobile.
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Tougan T, Aoshi T, Coban C, Katakai Y, Kai C, Yasutomi Y, Ishii KJ, Horii T.
TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models.
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Fujikura K, Setsu T, Tanigaki K, Abe T, Kiyonari H, Terashima T, Sakisaka T.
Kif14 mutation causes severe brain malformation and hypomyelination.
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Martinez-Argudo I, Veenendaal AK, Liu X, Roehrich AD, Ronessen MC, Franzoni G, van Rietschoten KN, Morimoto YV, Saijo-Hamano Y, Avison MB, Studholme DJ, Namba K, Minamino T, Blocker AJ.
Isolation of Salmonella Mutants Resistant to the Inhibitory Effect of Salicylidene acylhydrazides on Flagella-Mediated Motility.
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Ikeda K, Egawa A, Fujiwara T.
Secondary structural analysis of proteins based on (13)C chemical shift assignments in unresolved solid-state NMR spectra enhanced by fragmented structure database.
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Mitsuishi Y, Motohashi H, Yamamoto M.
The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism.
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Motoyama T, Hayashi T, Hirota H, Ueki M, Osada H.
Terpendole E, a Kinesin Eg5 Inhibitor, Is a Key Biosynthetic Intermediate of Indole-Diterpenes in the Producing Fungus Chaunopycnis alba.
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Futamura Y, Kawatani M, Kazami S, Tanaka K, Muroi M, Shimizu T, Tomita K, Watanabe N, Osada H.
Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.
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Goto M, Amino H, Nakajima M, Tsuji N, Sakamoto K, Kita K.
Cloning and characterization of hypoxia-inducible factor-1 subunits from Ascaris suum - a parasitic nematode highly adapted to changes of oxygen conditions during its life cycle.
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Miyakawa T, Fujita Y, Yamaguchi-Shinozaki K, Tanokura M.
Structure and function of abscisic acid receptors.
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Yanagisawa T, Sumida T, Ishii R, Yokoyama S.
A novel crystal form of pyrrolysyl-tRNA synthetase reveals the pre- and post-aminoacyl-tRNA synthesis conformational states of the adenylate and aminoacyl moieties and an asparagine residue in the catalytic site.
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Ohkoshi A, Suzuki T, Ono M, Kobayashi T, Yamamoto M.
Roles of Keap1-Nrf2 System in Upper Aerodigestive Tract Carcinogenesis.
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Miyauchi K, Kimura S, Suzuki T.
A cyclic form of N(6)-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification.
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Noda NN, Fujioka Y, Hanada T, Ohsumi Y, Inagaki F.
Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation.
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Higashi T, Tokuda S, Kitajiri SI, Masuda S, Nakamura H, Oda Y, Furuse M.
Analysis of the angulin family consisting of LSR, ILDR1 and ILDR2: tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis.
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Sasaki M, Tojo A, Okochi Y, Miyawaki N, Kamimura D, Yamaguchi A, Murakami M, Okamura Y.
Autoimmune disorder phenotypes in HVCN1 gene deficient mice.
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Nogawa T, Takahashi S, Sekiyama Y, Takagi H, Uramoto M, Koshino H, Kawatani M, Shimizu T, Osada H.
Creation of novel reveromycin derivatives by alcohol-added fermentation.
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Tagashira K, Fukuda W, Matsubara M, Kanai T, Atomi H, Imanaka T.
Genetic studies on the virus-like regions in the genome of hyperthermophilic archaeon, Thermococcus kodakarensis.
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Hikita M, Shinzawa-Itoh K, Moriyama M, Ogura T, Kihira K, Yoshikawa S.
Resonance Raman spectral properties of FMN of bovine heart NADH-ubiquinone oxidoreductase suggesting a mechanism for prevention of spontaneous production of reactive oxygen species.
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Akanuma G, Nanamiya H, Mouri Y, Ishizuka M, Ohnishi Y.
Proteomic Analysis of the Streptomyces griseus Ribosomal Fraction.
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Hattori Y, Furuita K, Ohki I, Ikegami T, Fukada H, Shirakawa M, Fujiwara T, Kojima C.
Utilization of lysine (13)C-methylation NMR for protein-protein interaction studies.
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Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T.
Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.
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Saimoto H, Kido Y, Haga Y, Sakamoto K, Kita K.
Pharmacophore identification of ascofuranone, potent inhibitor of cyanide-insensitive alternative oxidase of Trypanosoma brucei.
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Taniguchi M, Yoshinaga S, Haga-Yamanaka S, Touhara K, Terasawa H.
Backbone and side-chain (1)H, (15)N and (13)C assignments of mouse peptide ESP4.
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Fujiwara Y, Kurokawa T, Takeshita K, Nakagawa A, Larsson HP, Okamura Y.
Gating of the Designed Trimeric/Tetrameric Voltage-Gated H+ Channel.
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Murayama K, Kato-Murayama M, Akasaka R, Terada T, Yokoyama S, Shirouzu M.
Structure of the Rho-specific guanine nucleotide-exchange factor Xpln.
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Ibuki T, Uchida Y, Hironaka Y, Namba K, Imada K, Minamino T.
Interaction between FliJ and FlhA, components of the bacterial flagellar type III export apparatus.
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Total Synthesis of (+)-trans-Dihydronarciclasine Utilizing Asymmetric Conjugate Addition.
Yamada KI, Mogi Y, Mohamed MA, Takasu K, Tomioka K.
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Mizoi J, Ohori T, Moriwaki T, Kidokoro S, Todaka D, Maruyama K, Kusakabe K, Osakabe Y, Shinozaki K, Yamaguchi-Shinozaki K.
GmDREB2A;2, a Canonical DREB2-type Transcription Factor in Soybean, Is Post-translationally Regulated and Mediates DRE-dependent Gene Expression.
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Yamaguchi M, Matoba K, Sawada R, Fujioka Y, Nakatogawa H, Yamamoto H, Kobashigawa Y, Hoshida H, Akada R, Ohsumi Y, Noda NN, Inagaki F.
Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7.
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Kakuta S, Yamamoto H, Negishi L, Kondo-Kakuta C, Hayashi N, Ohsumi Y.
Atg9 vesicles recruit vesicle-tethering proteins, Trs85 and Ypt1, to the autophagosome formation site.
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Uchida Y, Minamino T, Namba K, Imada K.
Crystallization and preliminary X-ray analysis of the FliH-FliI complex responsible for bacterial flagellar type III protein export.
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Fukuhara S, Nishimasu H, Bonnefond L, Matsumoto N, Ishitani R, Nureki O.
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Zucchini from Drosophila melanogaster.
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Chujo T, Suzuki T.
Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs.
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Kitamura A, Nishimoto M, Sengoku T, Shibata R, Jager G, Bjork GR, Grosjean H, Yokoyama S, Bessho Y.
Characterization and structure of the Aquifex aeolicus protein DUF752: a bacterial tRNA-methyltransferase (MnmC2) functioning without the usually fused oxidase domain (MnmC1).
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Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T.
Activity-dependent proteolytic cleavage of neuroligin-1.
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Nishimasu H, Ishizu H, Saito K, Fukuhara S, Kamatani MK, Bonnefond L, Matsumoto N, Nishizawa T, Nakanaga K, Aoki J, Ishitani R, Siomi H, Siomi MC, Nureki O.
Structure and function of Zucchini endoribonuclease in piRNA biogenesis.
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Aono R, Sato T, Yano A, Yoshida S, Nishitani Y, Miki K, Imanaka T, Atomi H.
Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway.
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Masutani M, Machida K, Kobayashi T, Yokoyama S, Imataka H.
Reconstitution of eukaryotic translation initiation factor 3 by co-expression of the subunits in a human cell-derived in vitro protein synthesis system.
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Hou F, Miyakawa T, Takeshita D, Kataoka M, Uzura A, Nagata K, Shimizu S, Tanokura M.
Expression, purification, crystallization and X-ray analysis of 3-quinuclidinone reductase from Agrobacterium tumefaciens.
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Kato K, Nishimasu H, Okudaira S, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O.
Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
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Matsuki Y, Ueda K, Idehara T, Ikeda R, Ogawa I, Nakamura S, Toda M, Anai T, Fujiwara T.
Helium-cooling and -spinning dynamic nuclear polarization for sensitivity-enhanced solid-state NMR at 14T and 30K.
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Kang S, Kumanogoh A.
Semaphorins in bone development, homeostasis, and disease.
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Terasawa M, Uruno T, Mori S, Kukimoto-Niino M, Nishikimi A, Sanematsu F, Tanaka Y, Yokoyama S, Fukui Y.
Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration.
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Smith JL, Fischetti RF, Yamamoto M.
Micro-crystallography comes of age.
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Berman HM, Kleywegt GJ, Nakamura H, Markley JL.
The future of the protein data bank.
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Fukunaga S, Yamaguchi T, Ueno H, Yano Y, Hoshino M, Matsuzaki K.
GM1 cluster mediates formation of toxic Aβ fibrils by providing hydrophobic environments.
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Ogawa N, Yuki H, Tanaka A.
Insights from Pim1 structure for anti-cancer drug design.
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Tominaga T, Watanabe S, Matsumi R, Atomi H, Imanaka T, Miki K.
Structure of the [NiFe]-hydrogenase maturation protein HypF from Thermococcus kodakarensis KOD1.
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He F, Tsuda K, Takahashi M, Kuwasako K, Terada T, Shirouzu M, Watanabe S, Kigawa T, Kobayashi N, Güntert P, Yokoyama S, Muto Y.
Structural insight into the interaction of ADP-ribose with the PARP WWE domains.
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Tsuganezawa K, Nakagawa Y, Kato M, Taruya S, Takahashi F, Endoh M, Utata R, Mori M, Ogawa N, Honma T, Yokoyama S, Hashizume Y, Aoki M, Kasai T, Kigawa T, Kojima H, Okabe T, Nagano T, Tanaka A.
A Fluorescent-Based High-Throughput Screening Assay for Small Molecules That Inhibit the Interaction of MdmX with p53.
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Inoue A, Ishiguro J, Kitamura H, Arima N, Okutani M, Shuto A, Higashiyama S, Ohwada T, Arai H, Makide K, Aoki J.
TGFα shedding assay: an accurate and versatile method for detecting GPCR activation.
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Asaoka R, Uemura T, Ito J, Fujimoto M, Ito E, Ueda T, Nakano A.
Arabidopsis RABA1 GTPases are involved in the transport between the trans-Golgi network and the plasma membrane and are required for salinity stress tolerance.
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Koyama M, Nishimasu H, Ishitani R, Nureki O.
Molecular Dynamics Simulation of Autotaxin: Roles of the Nuclease-like Domain and the Glycan Modification.
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Todaka D, Nakashima K, Maruyama K, Kidokoro S, Osakabe Y, Ito Y, Matsukura S, Fujita Y, Yoshiwara K, Ohme-Takagi M, Kojima M, Sakakibara H, Shinozaki K, Yamaguchi-Shinozaki K.
Rice phytochrome-interacting factor-like protein OsPIL1 functions as a key regulator of internode elongation and induces a morphological response to drought stress.
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Hirotsu Y, Katsuoka F, Funayama R, Nagashima T, Nishida Y, Nakayama K, Douglas Engel J, Yamamoto M.
Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks.
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Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietli
In support of the BMRB.
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Kihira K, Shimizu Y, Shomura Y, Shibata N, Kitamura M, Nakagawa A, Ueda T, Ochi K, Higuchi Y.
Crystal structure analysis of the translation factor RF3 (release factor 3).
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Kondo Y, Hanai A, Nakai W, Katoh Y, Nakayama K, Shin HW.
ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.
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Ishibashi T, Tomita H, Yokooji Y, Morikita T, Watanabe B, Hiratake J, Kishimoto A, Kita A, Miki K, Imanaka T, Atomi H.
A detailed biochemical characterization of phosphopantothenate synthetase, a novel enzyme involved in coenzyme A biosynthesis in the Archaea.
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Uemura T, Ueda T, Nakano A.
The physiological role of SYP4 in the salinity and osmotic stress tolerances.
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Nomoto R, Tezuka T, Miyazono KI, Tanokura M, Horinouchi S, Ohnishi Y.
Purification, crystallization and preliminary X-ray analysis of SGR6054, a Streptomyces homologue of the mycobacterial integration host factor mIHF.
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Itoh Y, Sekine SI, Yokoyama S.
Crystallization and preliminary X-ray crystallographic analysis of Aquifex aeolicus SelA, a bacterial selenocysteine synthase.
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Kim JS, Mizoi J, Kidokoro S, Maruyama K, Nakajima J, Nakashima K, Mitsuda N, Takiguchi Y, Ohme-Takagi M, Kondou Y, Yoshizumi T, Matsui M, Shinozaki K, Yamaguchi-Shinozaki K.
Arabidopsis GROWTH-REGULATING FACTOR7 Functions as a Transcriptional Repressor of Abscisic Acid- and Osmotic Stress-Responsive Genes, Including DREB2A.
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Si D, Urano N, Shimizu S, Kataoka M.
LplR, a Repressor Belonging to the TetR Family, Regulates Expression of the L-Pantoyl Lactone Dehydrogenase Gene in Rhodococcus erythropolis.
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Shimizu R, Yamamoto M.
The contribution of GATA1 dysfunction to multi-step leukemogenesis.
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Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N.
Structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents.
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Qin HM, Miyakawa T, Nakamura A, Xue YL, Kawashima T, Kasahara T, Hibi M, Ogawa J, Tanokura M.
Expression, purification, crystallization and preliminary X-ray analysis of a novel N-substituted branched-chain L-amino-acid dioxygenase from Burkholderia ambifaria AMMD.
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Hida T, Yamashita N, Usui H, Nakamura F, Sasaki Y, Kikuchi A, Goshima Y.
GSK3β/Axin-1/β-Catenin Complex Is Involved in Semaphorin3A Signaling.
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Tokunaga F, Nishimasu H, Ishitani R, Goto E, Noguchi T, Mio K, Kamei K, Ma A, Iwai K, Nureki O.
Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.
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Otani Y, Kijima T, Kohmo S, Oishi S, Minami T, Nagatomo I, Takahashi R, Hirata H, Suzuki M, Inoue K, Takeda Y, Kida H, Tachibana I, Fujii N, Kumanogoh A.
Suppression of metastases of small cell lung cancer cells in mice by a peptidic CXCR4 inhibitor TF14016.
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Yokogawa M, Kobashigawa Y, Yoshida N, Ogura K, Harada K, Inagaki F.
NMR analyses of the interaction between the EEA1 FYVE domain and phosphoinositide embedded in lipid bilayer.
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Okatsu K, Oka T, Iguchi M, Imamura K, Kosako H, Tani N, Kimura M, Go E, Koyano F, Funayama M, Shiba-Fukushima K, Sato S, Shimizu H, Fukunaga Y, Taniguchi H, Komatsu M, Hattori N, Mihara K, Tanaka K, Matsuda N.
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.
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Kawahara-Kobayashi A, Masuda A, Araiso Y, Sakai Y, Kohda A, Uchiyama M, Asami S, Matsuda T, Ishitani R, Dohmae N, Yokoyama S, Kigawa T, Nureki O, Kiga D.
Simplification of the genetic code: restricted diversity of genetically encoded amino acids.
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Takahashi H, Ozawa A, Nemoto K, Nozawa A, Seki M, Shinozaki K, Takeda H, Endo Y, Sawasaki T.
Genome-wide biochemical analysis of Arabidopsis protein phosphatase using a wheat cell-free system.
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Mikami B, Ban M, Suzuki S, Yoon HJ, Miyake O, Yamasaki M, Ogura K, Maruyama Y, Hashimoto W, Murata K.
Induced-fit motion of a lid loop involved in catalysis in alginate lyase A1-III.
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Chiba H, Oishi S, Fujii N, Ohno H.
Total Synthesis of (-)-Quinocarcin by Gold(I)-Catalyzed Regioselective Hydroamination.
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Shimizu K, Takahama S, Endo Y, Sawasaki T.
Stress-Inducible Caspase Substrate TRB3 Promotes Nuclear Translocation of Procaspase-3.
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Nakano C, Tezuka T, Horinouchi S, Ohnishi Y.
Identification of the SGR6065 gene product as a sesquiterpene cyclase involved in (+)-epicubenol biosynthesis in Streptomyces griseus.
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Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.
Keap1 degradation by autophagy for the maintenance of redox homeostasis.
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Kikuchi S, Hara K, Shimizu T, Sato M, Hashimoto H.
Structural basis of recruitment of DNA polymerase ζ by interaction between REV1 and REV7.
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Hara-Yokoyama M, Kukimoto-Niino M, Terasawa K, Harumiya S, Podyma-Inoue KA, Hino N, Sakamoto K, Itoh S, Hashii N, Hiruta Y, Kawasaki N, Mishima-Tsumagari C, Kaitsu Y, Matsumoto T, Wakiyama M, Shirouzu M, Kasama T, Takayanagi H, Utsunomiya-Tate N, Takatsu K, Katada T, Hirabayashi Y, Yokoyama S, Yanagishita M.
Tetrameric Interaction of the Ectoenzyme CD38 on the Cell Surface Enables Its Catalytic and Raft-Association Activities.
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Izumi Y, Yanagihashi Y, Furuse M.
A novel protein complex, mesh-ssk, is required for septate junction formation in drosophila midgut.
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Yao MD, Miyazono KI, Ohtsuka J, Hirano S, Nagata K, Horinouchi S, Ohnishi Y, Tanokura M.
Purification, crystallization and preliminary X-ray analysis of the DNA-binding domain of AdpA, the central transcription factor in the A-factor regulatory cascade in the filamentous bacterium Streptomyces griseus, in complex with a duplex DNA.
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Parker LJ, Watanabe H, Tsuganezawa K, Tomabechi Y, Handa N, Shirouzu M, Yuki H, Honma T, Ogawa N, Nagano T, Yokoyama S, Tanaka A.
Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor.
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Guo L, Okai M, Mase T, Imai FL, Miyakawa T, Nagata K, Yamanaka H, Fujii H, Hibi M, Ogawa J, Tanokura M.
Expression, purification, crystallization and preliminary X-ray analysis of 4-hydroxy-3-methyl-2-keto-pentanoate aldolase (asHPAL) from Arthrobacter simplex strain AKU 626.
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Watanabe Y, Kobayashi T, Yamamoto H, Hoshida H, Akada R, Inagaki F, Ohsumi Y, Noda NN.
Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18.
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Nanjo T, Tsukano C, Takemoto Y.
Palladium-Catalyzed Cascade Process Consisting of Isocyanide Insertion and Benzylic C(sp(3))-H Activation: Concise Synthesis of Indole Derivatives.
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Kikuchi S, Hara K, Shimizu T, Sato M, Hashimoto H.
Crystallization and X-ray diffraction analysis of the ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment involved in translesion DNA synthesis.
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Ebine K, Uemura T, Nakano A, Ueda T.
Flowering Time Modulation by a Vacuolar SNARE via FLOWERING LOCUS C in Arabidopsis thaliana.
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Hara N, Morimoto YV, Kawamoto A, Namba K, Minamino T.
Interaction of the extreme N-terminal region of FliH with FlhA is required for efficient bacterial flagellar protein export.
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Daiyasu H, Nemoto W, Toh H.
Evolutionary Analysis of Functional Divergence among Chemokine Receptors, Decoy Receptors, and Viral Receptors.
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Tanaka H, Miyazaki N, Matoba K, Nogi T, Iwasaki K, Takagi J.
Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin.
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Goshima Y, Sasaki Y, Yamashita N, Nakamura F.
Class 3 semaphorins as a therapeutic target.
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Tamura T, Sakaeda T, Kadoyama K, Okuno Y.
Aspirin- and Clopidogrel-associated Bleeding Complications: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS.
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Komatsu M, Kageyama S, Ichimura Y.
p62/SQSTM1/A170: Physiology and Pathology.
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Arita K, Isogai S, Oda T, Unoki M, Sugita K, Sekiyama N, Kuwata K, Hamamoto R, Tochio H, Sato M, Ariyoshi M, Shirakawa M.
Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.
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Murayama K, Kato-Murayama M, Hosaka T, Sotokawauchi A, Yokoyama S, Arima K, Shirouzu M.
Crystal Structure of cucumisin, a subtilisin-like endoprotease from Cucumis melo L.
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Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N.
Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles.
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Yamamoto H, Kakuta S, Watanabe TM, Kitamura A, Sekito T, Kondo-Kakuta C, Ichikawa R, Kinjo M, Ohsumi Y.
Atg9 vesicles are an important membrane source during early steps of autophagosome formation.
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Kan-O M, Takeya R, Abe T, Kitajima N, Nishida M, Tominaga R, Kurose H, Sumimoto H.
Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis.
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Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M, Motohashi H.
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
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Nakatogawa H, Ohbayashi S, Sakoh-Nakatogawa M, Kakuta S, Suzuki SW, Kirisako H, Kondo-Kakuta C, Noda NN, Yamamoto H, Ohsumi Y.
The Autophagy-Related Protein Kinase Atg1 Interacts with the Ubiquitin-Like Protein Atg8 via the Atg8 Family Interacting Motif to Facilitate Autophagosome Formation.
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Kobayashi K, Saito K, Ishitani R, Ito K, Nureki O.
Structural basis for translation termination by archaeal RF1 and GTP-bound EF1α complex.
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Kato K, Nishimasu H, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O.
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 27.
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Ito Y, Uemura T, Shoda K, Fujimoto M, Ueda T, Nakano A.
cis-Golgi proteins accumulate near the ER exit sites and act as the scaffold for Golgi regeneration after brefeldin A treatment in tobacco BY-2 cells.
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Kimoto M, Yamashige R, Yokoyama S, Hirao I.
PCR Amplification and Transcription for Site-Specific Labeling of Large RNA Molecules by a Two-Unnatural-Base-Pair System.
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Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW, Yamamoto M.
Validation of the Multiple Sensor Mechanism of the Keap1-Nrf2 System.
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Desmet CJ, Ishii KJ.
Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination.
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Ishida M, Shimojo H, Hayashi A, Kawaguchi R, Ohtani Y, Uegaki K, Nishimura Y, Nakayama J.
Intrinsic Nucleic Acid-Binding Activity of Chp1 Chromodomain Is Required for Heterochromatic Gene Silencing.
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Kobayashi T, Suzuki K, Ohsumi Y.
Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2.
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Okai M, Ohtsuka J, Asano A, Guo L, Miyakawa T, Miyazono K, Nakamura A, Okada A, Zheng H, Kimura K, Nagata K, Tanokura M.
High pressure refolding, purification, and crystallization of flavin reductase from Sulfolobus tokodaii strain 7.
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Ginsbach JW, Kieber-Emmons MT, Nomoto R, Noguchi A, Ohnishi Y, Solomon EI.
Structure/function correlations among coupled binuclear copper proteins through spectroscopic and reactivity studies of NspF.
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Horinouchi N, Sakai T, Kawano T, Matsumoto S, Sasaki M, Hibi M, Shima J, Shimizu S, Ogawa J.
Construction of microbial platform for an energy-requiring bioprocess: practical 2'-deoxyribonucleoside production involving a C-C coupling reaction with high energy substrates.
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Horiuchi M, Takahasi K, Kobashigawa Y, Ochiai M, Inagaki F.
A low-cost affinity purification system using β-1,3-glucan recognition protein and curdlan beads.
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Nakamura K, Igarashi K, Ohkawa R, Yokota H, Masuda A, Nakagawa S, Yano T, Ikeda H, Aoki J, Yatomi Y.
Serum Autotaxin is not a Useful Biomarker for Ovarian Cancer.
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Tamura T, Sakaeda T, Kadoyama K, Okuno Y.
Omeprazole- and Esomeprazole-associated Hypomagnesaemia: Data Mining of the Public Version of the FDA Adverse Event Reporting System.
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Shiroishi M, Tsujimoto H, Makyio H, Asada H, Yurugi-Kobayashi T, Shimamura T, Murata T, Nomura N, Haga T, Iwata S, Kobayashi T.
Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae.
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Kobayashi N, Harano Y, Tochio N, Nakatani E, Kigawa T, Yokoyama S, Mading S, Ulrich EL, Markley JL, Akutsu H, Fujiwara T.
An automated system designed for large scale NMR data deposition and annotation: application to over 600 assigned chemical shift data entries to the BioMagResBank from the Riken Structural Genomics/Proteomics Initiative internal database.
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Tanaka TQ, Hirai M, Watanabe YI, Kita K.
Towards understanding the role of mitochondrial complex II in the intraerythrocytic stages of Plasmodium falciparum: Gene targeting of the Fp subunit.
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Takeo K, Watanabe N, Tomita T, Iwatsubo T.
Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1.
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Takahashi S, Kubo K, Waguri S, Yabashi A, Shin HW, Katoh Y, Nakayama K.
Rab11 regulates exocytosis of recycling vesicles at the plasma membrane.
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Nakamura K, Man Z, Xie Y, Hanai A, Makyio H, Kawasaki M, Kato R, Shin HW, Nakayama K, Wakatsuki S.
Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.
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Yamaguchi M, Noda NN, Yamamoto H, Shima T, Kumeta H, Kobashigawa Y, Akada R, Ohsumi Y, Inagaki F.
Structural Insights into Atg10-Mediated Formation of the Autophagy-Essential Atg12-Atg5 Conjugate.
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Furuse M, Oda Y, Higashi T, Iwamoto N, Masuda S.
Lipolysis-stimulated lipoprotein receptor: a novel membrane protein of tricellular tight junctions.
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Tokmakov AA, Kurotani A, Takagi T, Toyama M, Shirouzu M, Fukami Y, Yokoyama S.
Multiple post-translational modifications bear upon heterologous protein synthesis.
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Fukasawa R, Tsutsui T, Hirose Y, Tanaka A, Ohkuma Y.
Mediator CDK Subunits Are Platforms for Interactions with Various Chromatin Regulatory Complexes.
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Yoshikawa S, Muramoto K, Shinzawa-Itoh K.
Reaction mechanism of Mammalian mitochondrial cytochrome C oxidase.
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Shimono Y, Rikitake Y, Mandai K, Mori M, Takai Y.
Immunoglobulin superfamily receptors and adherens junctions.
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Yamauchi N, Takazawa Y, Maeda D, Hibiya T, Tanaka M, Iwabu M, Okada-Iwabu M, Yamauchi T, Kadowaki T, Fukayama M.
Expression Levels of Adiponectin Receptors are Decreased in Human Endometrial Adenocarcinoma Tissues.
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Iwayanagi T, Miyamoto S, Konno T, Mizutani H, Hirai T, Shigemoto Y, Gojobori T, Sugawara H.
TP Atlas: integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan.
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Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T, Okamura Y.
3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP).
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Shionyu M, Takahashi KI, Go M.
AS-EAST: A functional annotation tool for putative proteins encoded by alternatively spliced transcripts.
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Nemoto W, Toh H.
Functional region prediction with a set of appropriate homologous sequences-an index for sequence selection by integrating structure and sequence information with spatial statistics.
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Takeuchi M, Hirasawa A, Hara T, Kimura I, Hirano T, Suzuki T, Miyata N, Awaji T, Ishiguro M, Tsujimoto G.
FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models.
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Nishimura T, Honda H, Takeichi M.
Planar cell polarity links axes of spatial dynamics in neural-tube closure.
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Niwa T, Kanamori T, Ueda T, Taguchi H.
Global analysis of chaperone effects using a reconstituted cell-free translation system.
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Suzuki Y, Oishi S, Takei Y, Yasue M, Misu R, Naoe S, Hou Z, Kure T, Nakanishi I, Ohno H, Hirasawa A, Tsujimoto G, Fujii N.
Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles.
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Tokunaga F, Iwai K.
Linear ubiquitination: A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex.
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Wakiyama M, Kaitsu Y, Muramatsu R, Takimoto K, Yokoyama S.
Tethering of Proteins to RNAs using the BIV-Tat peptide and BIV-TAR RNA.
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Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I.
Analysis of NF-κB essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.
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Hibi M, Kawashima T, Sokolov PM, Smirnov SV, Kodera T, Sugiyama M, Shimizu S, Yokozeki K, Ogawa J.
L-Leucine 5-hydroxylase of Nostoc punctiforme is a novel type of Fe(II)/α-ketoglutarate-dependent dioxygenase that is useful as a biocatalyst.
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Hirotsu Y, Hataya N, Katsuoka F, Yamamoto M.
NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of Lipin1 and PGC-1β genes.
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Sato T, Sugimoto K, Inoue A, Okudaira S, Aoki J, Tokuyama H.
Synthesis and biological evaluation of optically active Ki16425.
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Kishikawa JI, Yokoyama K.
Reconstitution of Vacuolar type rotary H+-ATPase/synthase from Thermus thermophilus.
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Shimizu H, Osanai A, Sakamoto K, Inaoka DK, Shiba T, Harada S, Kita K.
Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum.
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Yoshida M, Shimono Y, Togashi H, Matsuzaki K, Miyoshi J, Mizoguchi A, Komori T, Takai Y.
Periderm cells covering palatal shelves have tight junctions and their desquamation reduces the polarity of palatal shelf epithelial cells in palatogenesis.
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Naoe S, Suzuki Y, Hirano K, Inaba Y, Oishi S, Fujii N, Ohno H.
Gold(I)-Catalyzed Regioselective Inter/Intramolecular Addition Cascade of Di- and Triynes for Direct Construction of Substituted Naphthalenes.
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Yuichiro Fujiwara, Tatsuki Kurokawa, Kohei Takeshita, Megumi Kobayashi, Yoshifumi Okochi, Atsushi Nakagawa, Yasushi Okamura
The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H+ channel Hv1
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Yamane M, Yamashita N, Yamamoto H, Iizuka A, Shouji M, Usui H, Goshima Y.
Semaphorin3A facilitates axonal transport through a local calcium signaling and tetrodotoxin-sensitive voltage-gated sodium channels.
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Sasaki Y, Urano N, Kataoka M, Ogawa J, Iwasaki A, Hasegawa J, Isobe K, Shimizu S.
Cloning and sequencing of a gene encoding of aldehyde oxidase in Pseudomonas sp. AIU 362.
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Sasaki H, Kubota K, Lee WC, Ohtsuka J, Kojima M, Iwata S, Nakagawa A, Takahashi K, Tanokura M.
The crystal structure of an intermediate dimer of aspergilloglutamic peptidase that mimics the enzyme-activation product complex produced upon autoproteolysis.
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Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, Kodama E, Matsuoka M, Fujii N.
Development and application of fluorescent SDF-1 derivatives.
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Matsumoto S, Igura M, Nyirenda J, Matsumoto M, Yuzawa S, Noda NN, Inagaki F, Kohda D.
Crystal structure of the C-terminal globular domain of oligosaccharyltransferase from Archaeoglobus fulgidus at 1.75 Å resolution.
-
Kaneko H, Kobayashi E, Yamamoto M, Shimizu R.
Amino- and carboxyl-terminal transactivation domains of GATA1 coordinate the hematopoietic program.
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Sato T, Watanabe H, Tsuganezawa K, Yuki H, Mikuni J, Yoshikawa S, Kukimoto-Niino M, Fujimoto T, Terazawa Y, Wakiyama M, Kojima H, Okabe T, Nagano T, Shirouzu M, Yokoyama S, Tanaka A, Honma T.
Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures.
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Nakano H, Saito N, Parker L, Tada Y, Abe M, Tsuganezawa K, Yokoyama S, Tanaka A, Kojima H, Okabe T, Nagano T.
Rational evolution of a novel type of potent and selective Proviral Integration site in Moloney murine leukemia kinase 1 (PIM1) inhibitor from a screening-hit compound.
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Iwai K.
Diverse ubiquitin signaling in NF-κB activation.
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Inoue D, Kimura I, Wakabayashi M, Tsumoto H, Ozawa K, Hara T, Takei Y, Hirasawa A, Ishihama Y, Tsujimoto G.
Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.
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Fujita Y, Yoshida T, Yamaguchi-Shinozaki K.
Pivotal role of the AREB/ABF-SnRK2 pathway in ABRE-mediated transcription in response to osmotic stress in plants.
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Makyio H, Ohgi M, Takei T, Takahashi S, Takatsu H, Katoh Y, Hanai A, Ueda T, Kanaho Y, Xie Y, Shin HW, Kamikubo H, Kataoka M, Kawasaki M, Kato R, Wakatsuki S, Nakayama K.
Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis.
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Akihiko Nishikimi, Takehito Uruno, Xuefeng Duan, Qinhong Cao, Yuji Okamura, Takashi Saitoh, Nae Saito, Shunsuke Sakaoka, Yao Du, Atsushi Suenaga, Mutsuko Kukimoto-Niino, Kei Miyano, Kazuhito Gotoh, Takayoshi Okabe, Fumiyuki Sanematsu, Yoshihiko Tanaka, Hideki Sumimoto, Teruki Honma, Shigeyuki Yokoyama, Tetsuo Nagano, Daisuke Kohda, Motomu Kanai, Yoshinori Fukui
Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2
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Oishi S, Fujii N.
Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4).
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Ishiuchi T, Takeichi M.
Nectins localize Willin to cell-cell junctions.
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Lee JM, Hull JJ, Kawai T, Tsuneizumi K, Kurihara M, Tanokura M, Nagata K, Nagasawa H, Matsumoto S.
Establishment of Sf9 Transformants Constitutively Expressing PBAN Receptor Variants: Application to Functional Evaluation.
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Mikihito Hayashi, Tomoki Nakashima, Masahiko Taniguchi, Tatsuhiko Kodama, Atsushi Kumanogoh & Hiroshi Takayanagi
Osteoprotection by Semaphorin 3A
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Nakamura A, Fujihashi M, Aono R, Sato T, Nishiba Y, Yoshida S, Yano A, Atomi H, Imanaka T, Miki K.
Dynamic, ligand-dependent conformational change triggers the reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1.
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Tanaka K, Mizushima T, Saeki Y.
The proteasome: molecular machinery and pathophysiological roles.
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Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, Yano Y, Matsuzaki K, Navenot JM, Peiper SC, Fujii N.
Paradoxical Downregulation of CXC Chemokine Receptor 4 Induced by Polyphemusin II-derived Antagonists.
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Ainoya K, Moriguchi T, Ohmori S, Souma T, Takai J, Morita M, Chandler KJ, Mortlock DP, Shimizu R, Engel JD, Lim KC, Yamamoto M.
UG4 enhancer-driven GATA-2 and BMP4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice.
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Fujikawa M, Imamura H, Nakamura J, Yoshida M.
Assessing the actual contribution of IF1, an inhibitor of mitochondrial FoF1, to ATP homeostasis, cell growth, mitochondrial morphology and cell viability.
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Nakatsuji Y, Okuno T, Moriya M, Sugimoto T, Kinoshita M, Takamatsu H, Nojima S, Kimura T, Kang S, Ito D, Nakagawa Y, Toyofuku T, Takata K, Nakano M, Kubo M, Suzuki S, Matsui-Hasumi A, Uto-Konomi A, Ogata A, Mochizuki H, Sakoda S, Kumanogoh A.
Elevation of Sema4A Implicates Th Cell Skewing and the Efficacy of IFN-β Therapy in Multiple Sclerosis.
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Nishitani Y, Maruyama Y, Itoh T, Mikami B, Hashimoto W, Murata K.
Recognition of heteropolysaccharide alginate by periplasmic solute-binding proteins of a bacterial ABC transporter.
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Oushiki D, Kojima H, Takahashi Y, Komatsu T, Terai T, Hanaoka K, Nishikawa M, Takakura Y, Nagano T.
Near-infrared Fluorescence Probes for Enzymes Based on Binding Affinity Modulation of Squarylium Dye Scaffold.
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Klionsky DJ and 1269 others
Guidelines for the use and interpretation of assays for monitoring autophagy.
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Hirano S, Takeichi M.
Cadherins in brain morphogenesis and wiring.
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Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Ikutani M, Takaki S, Sakamoto K, Hara-Yokoyama M, Shirouzu M, Takatsu K, Yokoyama S.
Structural basis of interleukin-5 dimer recognition by its α receptor.
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Okamoto M, Kurokawa K, Matsuura-Tokita K, Saito C, Hirata R, Nakano A.
High-curvature domains of the ER are important for the organization of ER exit sites in Saccharomyces cerevisiae.
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Toyofuku T, Nojima S, Ishikawa T, Takamatsu H, Tsujimura T, Uemura A, Matsuda J, Seki T, Kumanogoh A.
Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.
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Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y.
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
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Takahashi S, Tsuji K, Ueda T, Okahata Y.
Traveling time of a translating ribosome along mRNA monitored directly on a quartz crystal microbalance.
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Nagae M, Re S, Mihara E, Nogi T, Sugita Y, Takagi J.
Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor.
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Higo A, Hara H, Horinouchi S, Ohnishi Y.
Genome-wide Distribution of AdpA, a Global Regulator for Secondary Metabolism and Morphological Differentiation in Streptomyces, Revealed the Extent and Complexity of the AdpA Regulatory Network.
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Kadoyama K, Sakaeda T, Tamon A, Okuno Y.
Adverse event profile of tigecycline: data mining of the public version of the u.s. Food and drug administration adverse event reporting system.
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Noda NN, Kobayashi T, Adachi W, Fujioka Y, Ohsumi Y, Inagaki F.
STRUCTURE OF THE NOVEL C-TERMINAL DOMAIN OF VACUOLAR PROTEIN SORTING 30/AUTOPHAGY-RELATED PROTEIN 6 AND ITS SPECIFIC ROLE IN AUTOPHAGY.
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Kim SH, Oikawa T, Kyozuka J, Wong HL, Umemura K, Kishi-Kaboshi M, Takahashi A, Kawano Y, Kawasaki T, Shimamoto K.
The bHLH Rac Immunity1 (RAI1) Is Activated by OsRac1 via OsMAPK3 and OsMAPK6 in Rice Immunity.
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Kawai T, Lee JM, Nagata K, Matsumoto S, Tanokura M, Nagasawa H.
The Arginine Residue within the C-Terminal Active Core of Bombyx mori Pheromone Biosynthesis-Activating Neuropeptide is Essential for Receptor Binding and Activation.
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Yagi H, Ishimoto K, Hiromoto T, Fujita H, Mizushima T, Uekusa Y, Yagi-Utsumi M, Kurimoto E, Noda M, Uchiyama S, Tokunaga F, Iwai K, Kato K.
A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.
-
Hirano K, Kouketu E, Katoh H, Aya K, Ueguchi-Tanaka M, Matsuoka M.
The Suppressive Function of the Rice DELLA Protein SLR1 is Dependent on its Transcriptional Activation Activity.
-
Sato T, Yuki H, Takaya D, Sasaki S, Tanaka A, Honma T.
Application of Support Vector Machine to 3D shape-based virtual screening using comprehensive 3D molecular shape overlay with known inhibitors.
-
Sato Y, Horinouchi S, Ohnishi Y.
Characterization of a thermostable adenosine 5'-monophosphate deaminase gene in Streptomyces murinus.
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Ohtake K, Sato A, Mukai T, Hino N, Yokoyama S, Sakamoto K.
Efficient decoding of the UAG triplet as a full-fledged sense codon enhances the growth of the prfA-lacking strain of Escherichia coli.
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Walczak H, Iwai K, Dikic I.
Generation and physiological roles of linear ubiquitin chains.
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Ono S, Yano Y, Matsuzaki K.
Improvement of probe peptides for coiled-coil labeling by introducing phosphoserines.
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Yano K, Takashi T, Nagamatsu S, Kojima M, Sakakibara H, Kitano H, Matsuoka M, Aya K.
Efficacy of Microarray Profiling Data Combined with QTL Mapping for the Identification of a QTL Gene Controlling the Initial Growth Rate in Rice.
-
Niijima S, Shiraishi A, Okuno Y.
Dissecting kinase profiling data to predict activity and understand cross-reactivity of kinase inhibitors.
-
Goshima Y, Hida T, Gotoh T.
Computational analysis of axonal transport: a novel assessment of neurotoxicity, neuronal development and functions.
-
Berman HM, Kleywegt GJ, Nakamura H, Markley JL.
The protein data bank at 40: reflecting on the past to prepare for the future.
-
Kato N, Takahashi S, Nogawa T, Saito T, Osada H.
Construction of a microbial natural product library for chemical biology studies.
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Khan MM, Simizu S, Suzuki T, Masuda A, Kawatani M, Muroi M, Dohmae N, Osada H.
Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9.
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Higurashi M, Iketani M, Takei K, Yamashita N, Aoki R, Kawahara N, Goshima Y.
Localized role of CRMP1 and CRMP2 in neurite outgrowth and growth cone steering.
-
Moto K, Matsumoto S.
Construction of an in vivo System for Functional Analysis of the Genes Involved in Sex Pheromone Production in the Silkmoth, Bombyx mori.
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Sumida T, Stubbs KA, Ito M, Yokoyama S.
Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach.
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Kobayashi K, Oishi S, Hayashi R, Tomita K, Kubo T, Tanahara N, Ohno H, Yoshikawa Y, Furuya T, Hoshino M, Fujii N.
Structure-Activity Relationship Study of a CXC Chemokine Receptor Type 4 (CXCR4) Antagonist FC131 Using a Series of Alkene Dipeptide Isosteres.
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Kobayashi K, Oishi S, Kobayashi Y, Ohno H, Tsutsumi H, Hata Y, Fujii N.
Synthesis and application of an N(δ)-acetyl-N(δ)-hydroxyornithine analog: Identification of novel metal complexes of deferriferrichrysin.
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Yumen I, Iwasaki I, Suzuki T, Todokoro Y, Tanaka K, Okada O, Fujiwara T, Yoshida M, Akutsu H.
Purification, characterization and reconstitution into membranes of the oligomeric c-subunit ring of thermophilic F(o)F(1)-ATP synthase expressed in Escherichia coli.
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Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu T, Wolowczuk I, Tsujimoto G, Froguel P.
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
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Hou Z, Nakanishi I, Kinoshita T, Takei Y, Yasue M, Misu R, Suzuki Y, Nakamura S, Kure T, Ohno H, Murata K, Kitaura K, Hirasawa A, Tsujimoto G, Oishi S, Fujii N.
Structure-based Design of Novel Potent Protein Kinase CK2 (CK2) Inhibitors with Phenyl-azole Scaffolds.
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Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S.
Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
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Yanagihashi Y, Usui T, Izumi Y, Yonemura S, Sumida M, Tsukita S, Uemura T, Furuse M.
A novel smooth septate junction-associated membrane protein, Snakeskin, is required for intestinal barrier function in Drosophila.
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Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakurada A, Endo C, Uruno A, Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H, Yamamoto M.
p62/SQSTM1 Accumulation Is Associated with Poor Prognosis of Lung Adenocarcinoma Patients.
-
Yoshikawa Y, Kobayashi K, Oishi S, Fujii N, Furuya T.
Molecular modeling study of cyclic pentapeptide CXCR4 antagonists: New insight into CXCR4-FC131 interactions.
-
Kinjo AR, Nakamura H.
Composite structural motifs of binding sites for delineating biological functions of proteins.
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Takagi K, Kim S, Yukii H, Ueno M, Morishita R, Endo Y, Kato K, Tanaka K, Saeki Y, Mizushima T.
Structural basis for specific recognition of Rpt1, an ATPase subunit of the 26S proteasome, by a proteasome-dedicated chaperone Hsm3.
-
Takamatsu H, Kumanogoh A.
Diverse roles for semaphorin-plexin signaling in the immune system.
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Kondo-Okamoto N, Noda NN, Suzuki SW, Nakatogawa H, Takahashi I, Matsunami M, Hashimoto A, Inagaki F, Ohsumi Y, Okamoto K.
Autophagy-related protein 32 acts as an autophagic degron and directly initiates mitophagy.
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Yanagisawa T, Hino N, Iraha F, Mukai T, Sakamoto K, Yokoyama S.
Wide-range protein photo-crosslinking achieved by a genetically encoded N(ε )-(benzyloxycarbonyl)lysine derivative with a diazirinyl moiety.
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Uemura T, Kim H, Saito C, Ebine K, Ueda T, Schulze-Lefert P, Nakano A.
Qa-SNAREs localized to the trans-Golgi network regulate multiple transport pathways and extracellular disease resistance in plants.
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Tsuganezawa K, Watanabe H, Parker L, Yuki H, Taruya S, Nakagawa Y, Kamei D, Mori M, Ogawa N, Tomabechi Y, Handa N, Honma T, Yokoyama S, Kojima H, Okabe T, Nagano T, Tanaka A.
A Novel Pim-1 Kinase Inhibitor Targeting Residues That Bind the Substrate Peptide.
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Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Weyand S, Shimamura T, Nomura N, Cameron AD, Kobayashi T, Hamakubo T, Iwata S, Murata T.
G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody.
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Brown JB, Okuno Y.
Systems biology and systems chemistry: new directions for drug discovery.
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Komatsu Y, Waku T, Iwasaki N, Ono W, Yamaguchi C, Yanagisawa J.
Global analysis of DNA methylation in early-stage liver fibrosis.
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Wakamori M, Umehara T, Yokoyama S.
A tandem insertion vector for large-scale preparation of nucleosomal DNA.
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Tokunaga F, Iwai K.
LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses.
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Yamashita N, Ohshima T, Nakamura F, Kolattukudy P, Honnorat J, Mikoshiba K, Goshima Y.
Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization.
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Hasegawa A, Shimizu R, Mohandas N, Yamamoto M.
Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction.
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Lee JM, Hull JJ, Kawai T, Goto C, Kurihara M, Tanokura M, Nagata K, Nagasawa H, Matsumoto S.
Re-Evaluation of the PBAN Receptor Molecule: Characterization of PBANR Variants Expressed in the Pheromone Glands of Moths.
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Nishimasu H, Ishitani R, Aoki J, Nureki O.
A 3D view of autotaxin.
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Kato HE, Zhang F, Yizhar O, Ramakrishnan C, Nishizawa T, Hirata K, Ito J, Aita Y, Tsukazaki T, Hayashi S, Hegemann P, Maturana AD, Ishitani R, Deisseroth K, Nureki O.
Crystal structure of the channelrhodopsin light-gated cation channel.
-
Okazaki S, Kato R, Uchida Y, Taguchi T, Arai H, Wakatsuki S.
Structural basis of the strict phospholipid binding specificity of the pleckstrin homology domain of human evectin-2.
-
Rohaim A, Kawasaki M, Kato R, Dikic I, Wakatsuki S.
Structure of a compact conformation of linear diubiquitin.
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Nagata S, Matsumoto S, Mizoguchi A, Nagasawa H.
Identification of cDNAs encoding allatotropin and allatotropin-like peptides from the silkworm, Bombyx mori.
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Takeda Y, Yano Y, Matsuzaki K.
High-throughput analysis of ligand-induced internalization of β2-adrenoceptors using the coiled-coil tag-probe method.
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Nakano C, Funa N, Ohnishi Y, Horinouchi S.
The O-methyltransferase SrsB catalyzes the decarboxylative methylation of alkylresorcylic acid during phenolic lipid biosynthesis by Streptomyces griseus.
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Higo J, Ikebe J, Kamiya N, Nakamura H.
Enhanced and effective conformational sampling of protein molecular systems for their free energy landscapes.
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Niisato E, Nagai J, Yamashita N, Abe T, Kiyonari H, Goshima Y, Ohshima T.
CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus.
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Minamino T, Kinoshita M, Hara N, Takeuchi S, Hida A, Koya S, Glenwright H, Imada K, Aldridge PD, Namba K.
Interaction of a bacterial flagellar chaperone FlgN with FlhA is required for efficient export of its cognate substrates.
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Nakatogawa H, Ishii J, Asai E, Ohsumi Y.
Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis.
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Nara T, Hashimoto M, Hirawake H, Liao CW, Fukai Y, Suzuki S, Tsubouchi A, Morales J, Takamiya S, Fujimura T, Taka H, Mineki R, Fan CK, Inaoka DK, Inoue M, Tanaka A, Harada S, Kita K, Aoki T.
Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi.
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Tanaka H, Osakabe Y, Katsura S, Mizuno S, Maruyama K, Kusakabe K, Mizoi J, Shinozaki K, Yamaguchi-Shinozaki K.
Abiotic Stress-Inducible Receptor-Like Kinases Negatively Control ABA Signaling in Arabidopsis.
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Okada T, Hiromura M, Otsuka M, Enomoto S, Miyachi H.
Synthesis of BMS-309403-Related Compounds, Including [(14)C]BMS-309403, a Radioligand for Adipocyte Fatty Acid Binding Protein.
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Yoshikawa S, Muramoto K, Shinzawa-Itoh K, Mochizuki M.
Structural studies on bovine heart cytochrome c oxidase.
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Yamasaki K, Kigawa T, Watanabe S, Inoue M, Yamasaki T, Seki M, Shinozaki K, Yokoyama S.
Structural basis for sequence-specific DNA recognition by an Arabidopsis WRKY transcription factor.
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Ebine K, Miyakawa N, Fujimoto M, Uemura T, Nakano A, Ueda T.
Endosomal trafficking pathway regulated by ARA6, a RAB5 GTPase unique to plants.
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Kimura S, Ikeuchi Y, Kitahara K, Sakaguchi Y, Suzuki T, Suzuki T.
Base methylations in the double-stranded RNA by a fused methyltransferase bearing unwinding activity.
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Sakai C, Tomitsuka E, Esumi H, Harada S, Kita K.
Mitochondrial fumarate reductase as a target of chemotherapy: From parasites to cancer cells.
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He F, Inoue M, Kigawa T, Takahashi M, Kuwasako K, Tsuda K, Kobayashi N, Terada T, Shirouzu M, Güntert P, Yokoyama S, Muto Y.
Solution structure of the splicing factor motif of the human Prp18 protein.
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Kang S, Okuno T, Takegahara N, Takamatsu H, Nojima S, Kimura T, Yoshida Y, Ito D, Ohmae S, You DJ, Toyofuku T, Jang MH, Kumanogoh A.
Intestinal Epithelial Cell-Derived Semaphorin 7A Negatively Regulates Development of Colitis via αvβ1 Integrin.
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Hashimoto M, Morales J, Fukai Y, Suzuki S, Takamiya S, Tsubouchi A, Inoue S, Inoue M, Kita K, Harada S, Tanaka A, Aoki T, Nara T.
Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm.
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Nogawa T, Takahashi S, Okano A, Kawatani M, Uramoto M, Saito T, Osada H.
Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library.
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Miyachi H, Kuwabara N, Oyama T, Tomioka D, Ohashi M, Yanagisawa J, Shimizu T.
Peroxisome Proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: Phenypropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
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Maruyama K, Todaka D, Mizoi J, Yoshida T, Kidokoro S, Matsukura S, Takasaki H, Sakurai T, Yamamoto YY, Yoshiwara K, Kojima M, Sakakibara H, Shinozaki K, Yamaguchi-Shinozaki K.
Identification of Cis-Acting Promoter Elements in Cold- and Dehydration-Induced Transcriptional Pathways in Arabidopsis, Rice, and Soybean.
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Takashima K, Saitoh A, Hirose S, Nakai W, Kondo Y, Takasu Y, Kakeya H, Shin HW, Nakayama K.
GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER Transport Involved in Regulation of Lipid Homeostasis.
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Suzuki Y, Naoe S, Oishi S, Fujii N, Ohno H.
Gold-Catalyzed Three-Component Annulation: Efficient Synthesis of Highly Functionalized Dihydropyrazoles from Alkynes, Hydrazines, and Aldehydes or Ketones.
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Kuruma Y, Suzuki T, Ono S, Yoshida M, Ueda T.
Functional analysis of membraneous Fo-a subunit of F1Fo-ATP synthase by in vitro protein synthesis.
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Yamazaki H, Katsuoka F, Motohashi H, Engel JD, Yamamoto M.
Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.
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Shimada M, Saijo-Hamano Y, Furukawa Y, Minamino T, Imada K, Namba K.
Functional Defect and Restoration of Temperature-Sensitive Mutants of FlhA, a Subunit of the Flagellar Protein Export Apparatus.
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Sekine S, Tagami S, Yokoyama S.
Structural basis of transcription by bacterial and eukaryotic RNA polymerases.
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Ohnishi A, Kaji M, Hashimoto K, Matsumoto S.
Screening for the Genes Involved in Bombykol Biosynthesis: Identification and Functional Characterization of Bombyx mori Acyl Carrier Protein.
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Kobashigawa Y, Tomitaka A, Kumeta H, Noda NN, Yamaguchi M, Inagaki F.
Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b.
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Yamaguchi K, Imai K, Akamatsu A, Mihashi M, Hayashi N, Shimamoto K, Kawasaki T.
SWAP70 functions as a Rac/Rop guanine nucleotide-exchange factor in rice.
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Sato Y, Fujita H, Yoshikawa A, Yamashita M, Yamagata A, Kaiser SE, Iwai K, Fukai S.
Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex.
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Takeda M, Terauchi T, Kainosho M.
Conformational analysis by quantitative NOE measurements of the β-proton pairs across individual disulfide bonds in proteins.
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Suda Y, Nakano A.
The Yeast Golgi Apparatus.
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Saito C, Uemura T, Awai C, Ueda T, Abe H, Nakano A.
Qualitative difference between "bulb" membranes and other vacuolar membranes.
-
Uekusa Y, Mimura S, Sasakawa H, Kurimoto E, Sakata E, Olivier S, Yagi H, Tokunaga F, Iwai K, Kato K.
Backbone and side chain (1)H, (13)C, and (15)N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex.
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Usukura E, Suzuki T, Furuike S, Soga N, Saita EI, Hisabori T, Kinosita K Jr, Yoshida M.
Torque generation and utilization in the motor enzyme FoF1-ATP synthase: half-torque F1 with short-sized pushrod helix and reduced ATP synthesis by half-torque FoF1.
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Yu F, Tanaka Y, Yamashita K, Suzuki T, Nakamura A, Hirano N, Suzuki T, Yao M, Tanaka I.
Molecular basis of dihydrouridine formation on tRNA.
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Tsutsui T, Fukasawa R, Tanaka A, Hirose Y, Ohkuma Y.
Identification of target genes for the CDK subunits of the Mediator complex.
-
Yamashige R, Kimoto M, Takezawa Y, Sato A, Mitsui T, Yokoyama S, Hirao I.
Highly specific unnatural base pair systems as a third base pair for PCR amplification.
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Saijo S, Arai S, Hossain KM, Yamato I, Suzuki K, Kakinuma Y, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Iwata S, Murata T.
Crystal structure of the central axis DF complex of the prokaryotic V-ATPase.
-
Minamino T, Kinoshita M, Imada K, Namba K.
Interaction between FliI ATPase and a flagellar chaperone FliT during bacterial flagellar protein export.
-
Aya K, Hiwatashi Y, Kojima M, Sakakibara H, Ueguchi-Tanaka M, Hasebe M, Matsuoka M.
The Gibberellin perception system evolved to regulate a pre-existing GAMYB-mediated system during land plant evolution.
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Miyazono K, Tabei N, Morita S, Ohnishi Y, Horinouchi S, Tanokura M.
Substrate recognition mechanism and substrate-dependent conformational changes of an ROK family glucokinase from Streptomyces griseus.
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Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Okuda K, Sakamoto K, Shirouzu M, Shindo T, Yokoyama S.
Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.
-
Si D, Urano N, Shimizu S, Kataoka M.
Cloning and overexpression of ketopantoic acid reductase gene from Stenotrophomonas maltophilia and its application to stereospecific production of D-pantoic acid.
-
Kishino S, Park SB, Takeuchi M, Yokozeki K, Shimizu S, Ogawa J.
Novel multi-component enzyme machinery in lactic acid bacteria catalyzing CC double bond migration useful for conjugated fatty acid synthesis.
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Noda NN, Satoo K, Fujioka Y, Kumeta H, Ogura K, Nakatogawa H, Ohsumi Y, Inagaki F.
Structural basis of atg8 activation by a homodimeric e1, atg7.
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Imanaka T.
Molecular bases of thermophily in hyperthermophiles.
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Kim JS, Mizoi J, Yoshida T, Fujita Y, Nakajima J, Ohori T, Todaka D, Nakashima K, Hirayama T, Shinozaki K, Yamaguchi-Shinozaki K.
An ABRE promoter sequence is involved in osmotic stress-responsive expression of the DREB2A gene, which encodes a transcription factor regulating drought-inducible genes in Arabidopsis.
-
Coban C, Kobiyama K, Aoshi T, Takeshita F, Horii T, Akira S, Ishii KJ.
Novel Strategies to Improve DNA Vaccine Immunogenicity.
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Qin F, Kodaira K, Maruyama K, Mizoi J, Tran LS, Fujita Y, Morimoto K, Shinozaki K, Yamaguchi-Shinozaki K.
SPINDLY, a Negative Regulator of GA Signaling, Is Involved in the Plant Abiotic Stress Response.
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Nakano C, Kudo F, Eguchi T, Ohnishi Y.
Genome mining reveals two novel bacterial sesquiterpene cyclases: (-)-germacradien-4-ol and (-)-epi-α-bisabolol synthases from Streptomyces citricolor.
-
Terasaka N, Kimura S, Osawa T, Numata T, Suzuki T.
Biogenesis of 2-agmatinylcytidine catalyzed by the dual protein and RNA kinase TiaS.
-
Osawa T, Kimura S, Terasaka N, Inanaga H, Suzuki T, Numata T.
Structural basis of tRNA agmatinylation essential for AUA codon decoding.
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Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T.
Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.
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Obara K, Ohsumi Y.
Atg14: a key player in orchestrating autophagy
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Hashimoto T, Okudaira S, Igarashi K, Hama K, Yatomi Y, Aoki J.
Identification and biochemical characterization of a novel autotaxin isoform, ATX{delta}, with a four-amino acid deletion.
-
Abe R, Ohashi H, Iijima I, Ihara M, Takagi H, Hohsaka T, Ueda H.
"Quenchbodies": Quench-Based Antibody Probes That Show Antigen-Dependent Fluorescence.
-
Hu NJ, Iwata S, Cameron AD, Drew D.
Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.
-
Kinjo AR, Suzuki H, Yamashita R, Ikegawa Y, Kudou T, Igarashi R, Kengaku Y, Cho H, Standley DM, Nakagawa A, Nakamura H.
Protein Data Bank Japan (PDBj): maintaining a structural data archive and resource description framework format.
-
Kadoyama K, Kuwahara A, Yamamori M, Brown J, Sakaeda T, Okuno Y.
Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA Adverse Event Reporting System, AERS.
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Yukiura H, Hama K, Nakanaga K, Tanaka M, Asaoka Y, Okudaira S, Arima N, Inoue A, Hashimoto T, Arai H, Kawahara A, Nishina H, Aoki J.
Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish.
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Fleishman SJ, Whitehead TA, Strauch EM, Corn JE, Qin S, Zhou HX, Mitchell JC, Demerdash ON, Takeda-Shitaka M, Terashi G, Moal IH, Li X, Bates PA, Zacharias M, Park H, Ko JS, Lee H, Seok C, Bourquard T, Bernauer J, Poupon A, Azé J, Soner S, Ovali SK, Ozbek P, Tal NB, Haliloglu T, Hwang H, Vreven T, Pierce BG, Weng Z, Pérez-Cano L, Pons C, Fernández-Recio J, Jiang F, Yang F, Gong X, Cao L, Xu X, Liu B, Wang P, Li C, Wang C, Robert CH, Guharoy M, Liu S, Huang Y, Li L, Guo D, Chen Y, Xiao Y
Community-Wide Assessment of Protein-Interface Modeling Suggests Improvements to Design Methodology.
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Takeda M, Jee J, Ono AM, Terauchi T, Kainosho M.
Hydrogen Exchange Study on the Hydroxyl Groups of Serine and Threonine Residues in Proteins and Structure Refinement Using NOE Restraints with Polar Side-Chain Groups.
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Takahashi Y, Shimamoto K.
Heading date 1 (Hd1), an ortholog of Arabidopsis CONSTANS, is a possible target of human selection during domestication to diversify flowering times of cultivated rice.
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Navarro C, Abelenda JA, Cruz-Oró E, Cuéllar CA, Tamaki S, Silva J, Shimamoto K, Prat S.
Control of flowering and storage organ formation in potato by FLOWERING LOCUS T.
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Miyanoiri Y, Takeda M, Jee J, Ono AM, Okuma K, Terauchi T, Kainosho M.
Alternative SAIL-Trp for robust aromatic signal assignment and determination of the χ(2) conformation by intra-residue NOEs.
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Tomonaga M, Hashimoto N, Tokunaga F, Onishi M, Myoui A, Yoshikawa H, Iwai K.
Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells.
-
Minamino T, Morimoto YV, Hara N, Namba K.
An energy transduction mechanism used in bacterial flagellar type III protein export.
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Yoshida T, Ohama N, Nakajima J, Kidokoro S, Mizoi J, Nakashima K, Maruyama K, Kim JM, Seki M, Todaka D, Osakabe Y, Sakuma Y, Schöffl F, Shinozaki K, Yamaguchi-Shinozaki K.
Arabidopsis HsfA1 transcription factors function as the main positive regulators in heat shock-responsive gene expression.
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Takaya D, Yamashita A, Kamijo K, Gomi J, Ito M, Maekawa S, Enomoto N, Sakamoto N, Watanabe Y, Arai R, Umeyama H, Honma T, Matsumoto T, Yokoyama S.
A new method for induced fit docking (genius) and its application to virtual screening of novel HCV NS3-4A protease inhibitors.
-
Iwai K.
Linear polyubiquitin chains: A new modifier involved in NF-κB activation and chronic inflammation including dermatitis.
-
Takatsu H, Baba K, Shima T, Umino H, Kato U, Umeda M, Nakayama K, Shin HW.
ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50-independent manner.
-
Kikukawa T, Shimono K, Tamogami J, Miyauchi S, Kim SY, Kimura-Someya T, Shirouzu M, Jung KH, Yokoyama S, Kamo N.
Photochemistry of Acetabularia Rhodopsin II from a Marine Plant, Acetabularia acetabulum
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Ito E, Fujimoto M, Ebine K, Uemura T, Ueda T, Nakano A.
Dynamic behavior of clathrin in Arabidopsis thaliana unveiled by live imaging.
-
Nakano C, Kim HK, Ohnishi Y.
Identification and Characterization of the Linalool/Nerolidol Synthase from Streptomyces clavuligerus.
-
Kazami S, Usui T, Osada H.
Actin Stress Fiber Retraction and Aggresome Formation Is a Common Cellular Response to Actin Toxins.
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Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR.
The development of N-α-(2-carboxyl)benzoyl-N5-(2-fluoro-1-iminoethyl)-L-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N5-(2-Chloro-1-iminoethyl)-L-ornithine amide (o-Cl-amidine) as second generation Protein Arginine Deiminase (PAD)
-
Fukunishi Y, Mizukoshi Y, Takeuchi K, Shimada I, Takahashi H, Nakamura H.
Protein-ligand docking guided by ligand pharmacophore-mapping experiment by NMR.
-
Shibata T, Kokubu A, Saito S, Narisawa-Saito M, Sasaki H, Aoyagi K, Yoshimatsu Y, Tachimori Y, Kushima R, Kiyono T, Yamamoto M.
NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer.
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Mizutani K, Kawano S, Minami A, Waseda M, Ikeda W, Takai Y.
Interaction of nectin-like molecule 2 with integrin {alpha}6{beta}4 and inhibition of the disassembly of integrin {alpha}6{beta}4 from hemidesmosomes.
-
Kurita S, Ogita H, Takai Y
Cooperative role of the nectin-nectin and nectin-afadin interactions in the formation of the nectin-based cell-cell adhesion.
-
Shiroishi M, Kobayashi T, Ogasawara S, Tsujimoto H, Ikeda-Suno C, Iwata S, Shimamura T.
Production of the stable human histamine H(1) receptor in Pichia pastoris for structural determination.
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Homma K, Fukuchi S, Nishikawa K, Sakamoto S, Sugawara H.
Intrinsically disordered regions have specific functions in mitochondrial and nuclear proteins.
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Akashi M, Higashi T, Masuda S, Komori T, Furuse M.
A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions.
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Higo A, Horinouchi S, Ohnishi Y.
Strict regulation of morphological differentiation and secondary metabolism by a positive feedback loop between two global regulators AdpA and BldA in Streptomyces griseus.
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Sawaki H, Nakamura F, Aihara M, Nagashima Y, Komori-Yamaguchi J, Yamashita N, Nakazawa M, Goshima Y, Ikezawa Z.
Intranasal Administration of Semaphorin-3A Alleviates Sneezing and Nasal Rubbing in a Murine Model of Allergic Rhinitis.
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Kodaira K, Qin F, Tran LS, Maruyama K, Kidokoro S, Fujita Y, Shinozaki K, Yamaguchi-Shinozaki K.
Arabidopsis C2H2 Zinc-Finger Proteins AZF1 and AZF2 Negatively Regulate ABA-Repressive and Auxin-Inducible Genes under Abiotic Stress Conditions.
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Fukunishi Y, Wada M, Kanamori E, Nakamura H.
Selection of In-Silico Drug Screening Results for G-Protein-Coupled Receptors by Using Universal Active Probes.
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Sakaeda T, Kadoyama K, Okuno Y.
Adverse Event Profiles of Platinum Agents: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS, and Reproducibility of Clinical Observations.
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Mizoi J, Shinozaki K, Yamaguchi-Shinozaki K.
AP2/ERF family transcription factors in plant abiotic stress responses.
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Suzuki K, Morimoto M, Kondo C, Ohsumi Y.
Selective Autophagy Regulates Insertional Mutagenesis by the Ty1 Retrotransposon in Saccharomyces cerevisiae.
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Yasui N, Kitago Y, Beppu A, Kohno T, Morishita S, Gomi H, Nagae M, Hattori M, Takagi J.
Functional importance of covalent homodimer of reelin linked via its central region.
-
Taguchi K, Ishiuchi T, Takeichi M.
Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping.
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Mukai T, Yanagisawa T, Ohtake K, Wakamori M, Adachi J, Hino N, Sato A, Kobayashi T, Hayashi A, Shirouzu M, Umehara T, Yokoyama S, Sakamoto K.
Genetic-code evolution for protein synthesis with non-natural amino acids.
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Wakiyama M, Muramatsu R, Kaitsu Y, Ikeda M, Yokoyama S.
Inducible protein expression in Drosophila Schneider 2 cells using the lac operator-repressor system.
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Qin F, Shinozaki K, Yamaguchi-Shinozaki K.
Achievements and Challenges in Understanding Plant Abiotic Stress Responses and Tolerance.
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Kawai T, Akira S.
Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins.
-
Yamashige R, Kimoto M, Mitsui T, Yokoyama S, Hirao I.
Monitoring the site-specific incorporation of dual fluorophore-quencher base analogues for target DNA detection by an unnatural base pair system.
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Hibi M, Kawashima T, Kodera T, Smirnov SV, Sokolov PM, Sugiyama M, Shimizu S, Yokozeki K, Ogawa J.
Characterization of Bacillus thuringiensis L-isoleucine dioxygenase toward the production of useful amino acids.
-
Yoshimitsu Y, Oishi S, Miyagaki J, Inuki S, Ohno H, Fujii N.
Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C.
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Hayashi T, Kitamura Y, Funa N, Ohnishi Y, Horinouchi S.
Fatty Acyl-AMP Ligase Involvement in the Production of Alkylresorcylic Acid by a Myxococcus xanthus Type III Polyketide Synthase.
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Mizutani K, Yamamoto M, Suzuki K, Yamato I, Kakinuma Y, Shirouzu M, Walker JE, Yokoyama S, Iwata S, Murata T.
Structure of the rotor ring modified with N,N'-dicyclohexylcarbodiimide of the Na+-transporting vacuolar ATPase.
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Katayama T, Wilkinson MD, Vos R, Kawashima T, Kawashima S, Nakao M, Yamamoto Y, Chun HW, Yamaguchi A, Kawano S, Aerts J, Aoki-Kinoshita KF, Arakawa K, Aranda B, Bonnal RJ, Fernandez JM, Fujisawa T, Gordon PM, Goto N, Haider S, Harris T, Hatakeyama T, Ho I, Itoh M, Kasprzyk A, Kido N, Kim YJ, Kinjo AR, Konishi F, Kovarskaya Y, von Kuster G, Labarga A, Limviphuvadh V, McCarthy L, Nakamura Y, Nam Y, Nishida K, Nishimura K, Nishizawa T, Ogishima S, Oinn T, Okamoto S, Okuda S, Ono K, Oshita K, Park KJ, Putnam N,
The 2nd DBCLS BioHackathon: interoperable bioinformatics Web services for integrated applications.
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Taoka K, Ohki I, Tsuji H, Furuita K, Hayashi K, Yanase T, Yamaguchi M, Nakashima C, Purwestri YA, Tamaki S, Ogaki Y, Shimada C, Nakagawa A, Kojima C, Shimamoto K.
14-3-3 proteins act as intracellular receptors for rice Hd3a florigen.
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Aoshi T, Koyama S, Kobiyama K, Akira S, Ishii KJ.
Innate and adaptive immune responses to viral infection and vaccination.
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Ashikawa Y, Ihara M, Matsuura N, Fukunaga Y, Kusakabe Y, Yamashita A.
GFP-based evaluation system of recombinant expression through the secretory pathway in insect cells and its application to the extracellular domains of class C GPCRs.
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Togashi H, Kominami K, Waseda M, Komura H, Miyoshi J, Takeichi M, Takai Y.
Nectins Establish a Checkerboard-like Cellular Pattern in the Auditory Epithelium.
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Takahashi S, Takei T, Koga H, Takatsu H, Shin HW, Nakayama K.
Distinct roles of Rab11 and Arf6 in the regulation of Rab11-FIP3/arfophilin-1 localization in mitotic cells.
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Kurachi M, Kurachi J, Suenaga F, Tsukui T, Abe J, Ueha S, Tomura M, Sugihara K, Takamura S, Kakimi K, Matsushima K.
Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration.
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Hara N, Namba K, Minamino T.
Genetic characterization of conserved charged residues in the bacterial flagellar type III export protein FlhA.
-
Hara N, Namba K, Minamino T.
Genetic Characterization of Conserved Charged Residues in the Bacterial Flagellar Type III Export Protein FlhA.
-
Rahman S, Arai S, Saijo S, Yamato I, Murata T.
Sarkosyl is a good regeneration reagent for studies on vacuolar-type ATPase subunit interactions in Biacore experiments.
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Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, Lekeux P, Coban C, Akira S, Ishii KJ, Bureau F, Desmet CJ.
DNA released from dying host cells mediates aluminum adjuvant activity.
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Yano Y, Yamamoto A, Ogura M, Matsuzaki K.
Thermodynamics of Insertion and Self-Association of a Transmembrane Helix: A Lipophobic Interaction by Phosphatidylethanolamine.
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Suga M, Yano N, Muramoto K, Shinzawa-Itoh K, Maeda T, Yamashita E, Tsukihara T, Yoshikawa S.
Distinguishing between Cl(-) and O(2)(2-) as the bridging element between Fe(3+) and Cu(2+) in resting-oxidized cytochrome c oxidase.
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Sakamoto K, Kamiya M, Imai M, Shinzawa-Itoh K, Uchida T, Kawano K, Yoshikawa S, Ishimori K.
NMR basis for interprotein electron transfer gating between cytochrome c and cytochrome c oxidase.
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Matsubara K, Yokooji Y, Atomi H, Imanaka T.
Biochemical and genetic characterization of the three metabolic routes in Thermococcus kodakarensis linking glyceraldehyde-3-phosphate and 3-phosphoglycerate.
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Atomi H, Sato T, Kanai T.
Application of hyperthermophiles and their enzymes.
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Kinoshita T, Sekiguchi Y, Fukada H, Nakaniwa T, Tada T, Nakamura S, Kitaura K, Ohno H, Suzuki Y, Hirasawa A, Nakanishi I, Tsujimoto G.
A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase.
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Kubori T, Nagai H.
Bacterial effector-involved temporal and spatial regulation by hijack of the host ubiquitin pathway.
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Tagami S, Sekine SI, Yokoyama S.
A novel conformation of RNA polymerase sheds light on the mechanism of transcription.
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Kawaguchi M, Okabe T, Okudaira S, Hanaoka K, Fujikawa Y, Terai T, Komatsu T, Kojima H, Aoki J, Nagano T.
Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor.
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Nakano C, Kim HK, Ohnishi Y.
Identification of the First Bacterial Monoterpene Cyclase, a 1,8-Cineole Synthase, that Catalyzes the Direct Conversion of Geranyl Diphosphate.
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Isogai S, Morimoto D, Arita K, Unzai S, Tenno T, Hasegawa J, Sou YS, Komatsu M, Tanaka K, Shirakawa M, Tochio H.
Crystal structure of the UBA domain of p62 and its interaction with ubiquitin.
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Nagai H, Kubori T.
Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria.
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Oda H, Takeichi M.
Structural and functional diversity of cadherin at the adherens junction.
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Wada T, Shimono K, Kikukawa T, Hato M, Shinya N, Kim SY, Kimura-Someya T, Shirouzu M, Tamogami J, Miyauchi S, Jung KH, Kamo N, Yokoyama S.
Crystal Structure of the Eukaryotic Light-Driven Proton-Pumping Rhodopsin, Acetabularia Rhodopsin II, from Marine Alga.
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Ehara H, Sekine S, Yokoyama S.
Crystal structure of the C17/25 subcomplex from Schizosaccharomyces pombe RNA Polymerase III.
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Yano Y, Matsuzaki K.
Fluorescence ratiometric detection of ligand-induced receptor internalization using extracellular coiled-coil tag-probe labeling.
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Kawatani M, Takayama H, Muroi M, Kimura S, Maekawa T, Osada H.
Identification of a Small-Molecule Inhibitor of DNA Topoisomerase II by Proteomic Profiling.
-
Dasgupta B, Nakamura H, Kinjo AR.
Distinct Roles of Overlapping and Non-overlapping Regions of Hub Protein Interfaces in Recognition of Multiple Partners.
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Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S.
Structure of the human histamine H(1) receptor complex with doxepin.
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Yoshikawa S, Muramoto K, Shinzawa-Itoh K.
The O(2) reduction and proton pumping gate mechanism of bovine heart cytochrome c oxidase.
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Nakano C, Horinouchi S, Ohnishi Y.
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus.
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Ishiuchi T, Takeichi M.
Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
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Ikeda K, Kameda T, Harada E, Akutsu H, Fujiwara T.
Combined Use of Replica-Exchange Molecular Dynamics and Magic-Angle-Spinning Solid-State NMR Spectral Simulations for Determining the Structure and Orientation of Membrane-Bound Peptide.
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Shindo Y, Morishita K, Kotake E, Miura H, Carninci P, Kawai J, Hayashizaki Y, Hino A, Kanda T, Kusakabe Y.
FXYD6, a Na,K-ATPase Regulator, Is Expressed in Type II Taste Cells.
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Ebine K, Fujimoto M, Okatani Y, Nishiyama T, Goh T, Ito E, Dainobu T, Nishitani A, Uemura T, Sato MH, Thordal-Christensen H, Tsutsumi N, Nakano A, Ueda T.
A membrane trafficking pathway regulated by the plant-specific RAB GTPase ARA6.
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Sakata E, Stengel F, Fukunaga K, Zhou M, Saeki Y, Förster F, Baumeister W, Tanaka K, Robinson CV.
The catalytic activity of ubp6 enhances maturation of the proteasomal regulatory particle.
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Asano K, Yamasaki M, Takuno S, Miura K, Katagiri S, Ito T, Doi K, Wu J, Ebana K, Matsumoto T, Innan H, Kitano H, Ashikari M, Matsuoka M.
Artificial selection for a green revolution gene during japonica rice domestication.
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Takahashi S, Toyoda A, Sekiyama Y, Takagi H, Nogawa T, Uramoto M, Suzuki R, Koshino H, Kumano T, Panthee S, Dairi T, Ishikawa J, Ikeda H, Sakaki Y, Osada H.
Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation.
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Saito C, Uemura T, Awai C, Tominaga M, Ebine K, Ito J, Ueda T, Abe H, Morita MT, Tasaka M, Nakano A.
The occurrence of bulbs, a complex configuration of the vacuolar membrane, is affected by mutations of vacuolar SNARE and phospholipase in Arabidopsis.
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Miyashita H, Maruyama Y, Isshiki H, Osawa S, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T.
Three-dimensional structure of the signal peptide peptidase.
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Higo J, Nishimura Y, Nakamura H.
A Free-energy Landscape for Coupled Folding and Binding of an Intrinsically Disordered Protein in Explicit Solvent from Detailed All-atom Computations.
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Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G.
Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders.
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Panthee S, Takahashi S, Takagi H, Nogawa T, Oowada E, Uramoto M, Osada H.
Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds from Streptomyces reveromyceticus SN-593.
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Arakawa A, Handa N, Shirouzu M, Yokoyama S.
Biochemical and structural studies on the high affinity of Hsp70 for ADP.
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Kato N, Tokuoka M, Shinohara Y, Kawatani M, Uramoto M, Seshime Y, Fujii I, Kitamoto K, Takahashi T, Takahashi S, Koyama Y, Osada H.
Genetic Safeguard against Mycotoxin Cyclopiazonic Acid Production in Aspergillus oryzae.
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Takeuchi T, Oishi S, Watanabe T, Ohno H, Sawada J, Matsuno K, Asai A, Asada N, Kitaura K, Fujii N.
Structure-activity Relationships of Carboline and Carbazole Derivatives as a Novel Class of ATP-competitive Kinesin Spindle Protein Inhibitors.
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Iwata A, Inuki S, Oishi S, Fujii N, Ohno H.
Formal Total Synthesis of (+)-Lysergic Acid via Zinc(II)-Mediated Regioselective Ring-Opening Reduction of 2-Alkynyl-3-indolyloxirane.
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Saitoh T, Igura M, Miyazaki Y, Ose T, Maita N, Kohda D.
Crystallographic snapshots of Tom20-mitochondrial presequence interactions with disulfide-stabilized peptides.
-
Ohnishi A, Hull JJ, Kaji M, Hashimoto K, Lee JM, Tsuneizumi K, Suzuki T, Dohmae N, Matsumoto S.
Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of the insect PAT family protein Bombyx mori lipid storage droplet protein-1 (BmLSD1).
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Kitamura A, Sengoku T, Nishimoto M, Yokoyama S, Bessho Y.
Crystal structure of the bifunctional tRNA modification enzyme MnmC from Escherichia coli.
-
Goto N, Hiyoshi H, Ito I, Tsuchiya M, Nakajima Y, Yanagisawa J.
Estrogen and antiestrogens alter breast cancer invasiveness by modulating TGF-β signaling pathway.
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Tsukazaki T, Mori H, Echizen Y, Ishitani R, Fukai S, Tanaka T, Perederina A, Vassylyev DG, Kohno T, Maturana AD, Ito K, Nureki O.
Structure and function of a membrane component SecDF that enhances protein export.
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Shindoh N, Kitaura K, Takemoto Y, Takasu K.
Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β-Unsaturated Amidines.
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Kobayashi A, Tsukide T, Miyasaka T, Morita T, Mizoroki T, Saito Y, Ihara Y, Takashima A, Noguchi N, Fukamizu A, Hirotsu Y, Ohtsuji M, Katsuoka F, Yamamoto M.
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.
-
Yoshikawa S, Muramoto K, Shinzawa-Itoh K.
Proton-pumping mechanism of cytochrome C oxidase.
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Matsuda M, Takeshita K, Kurokawa T, Sakata S, Suzuki M, Yamashita E, Okamura Y, Nakagawa A.
Crystal structure of the cytoplasmic PTEN-like region of Ci-VSP provides insight into substrate specificity and redox regulation of the phosphoinositide phosphatase activity.
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Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T.
BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate.
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Mizuki F, Tanaka A, Hirose Y, Ohkuma Y.
The HIRA Complex Subunit Hip3 Plays Important Roles in the Silencing of Meiosis-Specific Genes in Schizosaccharomyces pombe.
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Tanaka H, Nogi T, Yasui N, Iwasaki K, Takagi J.
Structural Basis for Variant-Specific Neuroligin-Binding by α-Neurexin.
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Fukunishi Y, Nakamura H.
Definition of Drug-Likeness for Compound Affinity.
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Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, Aoshi T, Ishii KJ, Akira S, Uematsu S.
A New Subset of CD103+CD8{alpha}+ Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity.
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Takeshita K, Suetake I, Yamashita E, Suga M, Narita H, Nakagawa A, Tajima S.
Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1).
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Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G.
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).
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Noma A, Yi S, Katoh T, Takai Y, Suzuki T, Suzuki T.
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.
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Ito T, Umehara T, Sasaki K, Nakamura Y, Nishino N, Terada T, Shirouzu M, Padmanabhan B, Yokoyama S, Ito A, Yoshida M.
Real-Time Imaging of Histone H4K12-Specific Acetylation Determines the Modes of Action of Histone Deacetylase and Bromodomain Inhibitors.
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Asada H, Uemura T, Yurugi-Kobayashi T, Shiroishi M, Shimamura T, Tsujimoto H, Ito K, Sugawara T, Nakane T, Nomura N, Murata T, Haga T, Iwata S, Kobayashi T.
Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis.
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Ishikawa R, Aoki M, Kurotani KI, Yokoi S, Shinomura T, Takano M, Shimamoto K.
Phytochrome B regulates Heading date 1 (Hd1)-mediated expression of rice florigen Hd3a and critical day length in rice.
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Akagi T, Shimizu K, Takahama S, Iwasaki T, Sakamaki K, Endo Y, Sawasaki T.
Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling.
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Kukimoto-Niino M, Yoshikawa S, Takagi T, Ohsawa N, Tomabechi Y, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S.
Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609.
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Yamasaki T, Ito Y, Mito F, Kitagawa K, Matsuoka Y, Yamato M, Yamada K.
Structural Concept of Nitroxide As a Lipid Peroxidation Inhibitor.
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Tokuda N, Igarashi K, Shimamura T, Yurugi-Kobayashi T, Shiroishi M, Ito K, Sugawara T, Asada H, Murata T, Nomura N, Iwata S, Kobayashi T.
Cloning, expression and purification of the anion exchanger 1 homolog from the basidiomycete Phanerochaete chrysosporium.
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Handa N, Takagi T, Saijo S, Kishishita S, Takaya D, Toyama M, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S.
Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain.
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Y. Nakajima, K. Akaogi, T. Suzuki, A. Osakabe, C. Yamaguchi, N. Sunahara, J. Ishida, K. Kako, S. Ogawa, T. Fujimura, Y. Homma, A. Fukamizu, A. Murayama, K. Kimura, S. Inoue, J. Yanagisawa
Estrogen Regulates Tumor Growth Through a Nonclassical Pathway that Includes the Transcription Factors ERβ and KLF5.
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Nozawa A, Ogasawara T, Matsunaga S, Iwasaki T, Sawasaki T, Endo Y.
Production and partial purification of membrane proteins using a liposome-supplemented wheat cell-free translation system.
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Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M.
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
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Okamoto M, Kojima H, Saito N, Okabe T, Masuda Y, Furuya T, Nagano T.
Virtual screening and further development of novel ALK inhibitors.
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Nemoto K, Seto T, Takahashi H, Nozawa A, Seki M, Shinozaki K, Endo Y, Sawasaki T.
Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system.
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Awazawa M, Ueki K, Inabe K, Yamauchi T, Kubota N, Kaneko K, Kobayashi M, Iwane A, Sasako T, Okazaki Y, Ohsugi M, Takamoto I, Yamashita S, Asahara H, Akira S, Kasuga M, Kadowaki T.
Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway.
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Sakata S, Hossain MI, Okamura Y.
Coupling of the phosphatase activity of Ci-VSP to its voltage sensor activity over the entire range of voltage sensitivity.
-
Masuda R, Oishi S, Ohno H, Kimura H, Saji H, Fujii N.
Concise site-specific synthesis of DTPA-peptide conjugates: Application to imaging probes for the chemokine receptor CXCR4.
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Bridging the gap between single-template and fragment based protein structure modeling using Spanner.
Lis M, Kim T, Sarmiento JJ, Kuroda D, Dinh HV, Kinjo AR, Amada K, Devadas S, Nakamura H, Standley DM.
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Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S, Tanaka K, Nakano H, Iwai K.
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.
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Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I.
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
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Terazawa Y, Wakiyama M, Yokoyama S.
pCMV-Leu2/pUCA-Neo, a vector set for screening Schizosaccharomyces pombe transformants expressing heterologous proteins.
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Mito F, Yamasaki T, Ito Y, Yamato M, Mino H, Sadasue H, Shirahama C, Sakai K, Utsumi H, Yamada K.
Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical.
-
Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S.
Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells.
-
Umetsu Y, Goda N, Taniguchi R, Satomura K, Ikegami T, Furuse M, Hiroaki H.
(1)H, (13)C, and (15)N resonance assignment of the first PDZ domain of mouse ZO-1.
-
Suzuki T, Wakabayashi C, Tanaka K, Feniouk BA, Yoshida M.
Modulation of nucleotide specificity of thermophilic FoF1-ATP synthase by {epsilon}-subunit.
-
Kuratani M, Kasai T, Akasaka R, Higashijima K, Terada T, Kigawa T, Shinkai A, Bessho Y, Yokoyama S.
Crystal structure of sulfolobus tokodaii sua5 complexed with L-threonine and AMPPNP.
-
Miura K, Ashikari M, Matsuoka M.
The role of QTLs in the breeding of high-yielding rice.
-
Inokuchi E, Yamada A, Hozumi K, Tomita K, Oishi S, Ohno H, Nomizu M, Fujii N.
Design and synthesis of amidine-type peptide bond isosteres: application of nitrile oxide derivatives as active ester equivalents in peptide and peptidomimetics synthesis.
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Okuno T, Nakatsuji Y, Kumanogoh A.
The role of immune semaphorins in multiple sclerosis.
-
Fujita Y, Fujita M, Shinozaki K, Yamaguchi-Shinozaki K.
ABA-mediated transcriptional regulation in response to osmotic stress in plants.
-
Nemoto W, Fukui K, Toh H.
GRIPDB - G protein coupled Receptor Interaction Partners DataBase.
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Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y.
Autotaxin as a novel serum marker of liver fibrosis.
-
Rikitake Y, Takai Y.
Directional Cell Migration Regulation by Small G Proteins, Nectin-like Molecule-5, and Afadin.
-
Hirotsu Y, Katsuoka F, Itoh K, Yamamoto M.
Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers.
-
Furuike S, Nakano M, Adachi K, Noji H, Kinosita K Jr, Yokoyama K.
Resolving stepping rotation in Thermus thermophilus H(+)-ATPase/synthase with an essentially drag-free probe.
-
Chiba S, Kanamori T, Ueda T, Akiyama Y, Pogliano K, Ito K.
Recruitment of a species-specific translational arrest module to monitor different cellular processes.
-
Sasaki Y, Asayama W, Niwa T, Sawada SI, Ueda T, Taguchi H, Akiyoshi K.
Amphiphilic Polysaccharide Nanogels as Artificial Chaperones in Cell-Free Protein Synthesis.
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Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.
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Yabuuchi H, Niijima S, Takematsu H, Ida T, Hirokawa T, Hara T, Ogawa T, Minowa Y, Tsujimoto G, Okuno Y.
Analysis of multiple compound-protein interactions reveals novel bioactive molecules.
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Inuki S, Iwata A, Oishi S, Fujii N, Ohno H.
Enantioselective Total Synthesis of (+)-Lysergic Acid, (+)-Lysergol, and (+)-Isolysergol by Palladium-Catalyzed Domino Cyclization of Allenes Bearing Amino and Bromoindolyl Groups.
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Ong EB, Watanabe N, Saito A, Futamura Y, Abd El Galil KH, Koito A, Najimudin N, Osada H.
VIPIRININ, a coumarin-based HIV-1 VPR inhibitor, interacts with a hydrophobic region of VPR.
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Igura M, Kohda D.
Selective control of oligosaccharide transfer efficiency for the N-glycosylation sequon by a point mutation in oligosaccharyltransferase.
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Okamura Y, Dixon JE.
Voltage-Sensing Phosphatase: Its Molecular Relationship With PTEN.
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Tsutomu S, Asuteka N, Takeo S.
Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs.
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Suzuki SW, Onodera J, Ohsumi Y.
Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction.
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Rahman S, Ishizuka-Katsura Y, Arai S, Saijo S, Yamato I, Toyama M, Ohsawa N, Inoue M, Honda K, Terada T, Shirouzu M, Yokoyama S, Iwata S, Murata T.
Expression, Purification and Characterization of Isoforms of Peripheral stalk subunits of Human V-ATPase.
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Fonagy A, Moto K, Ohnishi A, Kurihara M, Kis J, Matsumoto S.
Studies of sex pheromone production under neuroendocrine control by analytical and morphological means in the oriental armyworm, Pseudaletia separata, Walker (Lepidoptera: Noctuidae).
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Ito K, Ito S, Shimamura T, Weyand S, Kawarasaki Y, Misaka T, Abe K, Kobayashi T, Cameron AD, Iwata S.
Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans.
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Moriya N, Minamino T, Imada K, Namba K.
Genetic analysis of the bacterial hook-capping protein FlgD responsible for hook assembly.
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Ohsakaya S, Fujikawa M, Hisabori T, Yoshida M.
Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondria.
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Kato N, Suzuki H, Takagi H, Uramoto M, Takahashi S, Osada H.
Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus.
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Mori T, Hidaka M, Lin YC, Yoshizawa I, Okabe T, Egashira S, Kojima H, Nagano T, Koketsu M, Takamiya M, Uchida T.
A Dual Inhibitor Against Prolyl Isomerase Pin1 and Cyclophilin Discovered by a Novel Real-Time Fluorescence Detection Method.
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Bonnefond L, Arai T, Sakaguchi Y, Suzuki T, Ishitani R, Nureki O.
Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog.
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Narita H, Yamamoto Y, Suzuki M, Miyazaki N, Yoshida A, Kawai K, Iwasaki K, Nakagawa A, Takai Y, Sakisaka T.
Crystal structure of the cis-dimer of nectin-1: implications for the architecture of cell-cell junctions.
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Hijikata A, Yura K, Noguti T, Go M.
Revisiting gap locations in amino acid sequence alignments and a proposal for a method to improve them by introducing solvent accessibility.
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Tatsumi K, Yamamoto-Mukai H, Shimizu R, Waguri S, Sou YS, Sakamoto A, Taya C, Shitara H, Hara T, Chung CH, Tanaka K, Yamamoto M, Komatsu M.
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice.
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Kishino S, Ogawa J, Yokozeki K, Shimizu S.
Linoleic Acid Isomerase in Lactobacillus plantarum AKU1009a Proved to Be a Multi-Component Enzyme System Requiring Oxidoreduction Cofactors.
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Inn KS, Gack MU, Tokunaga F, Shi M, Wong LY, Iwai K, Jung JU.
Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction.
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Kodera C, Yorimitsu T, Nakano A, Sato K.
Sed4p stimulates Sar1p GTP hydrolysis and promotes limited coat disassembly.
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Imanaka Y, Tsuchiya S, Sato F, Shimada Y, Shimizu K, Tsujimoto G.
MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma.
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Kadowaki T, Yamauchi T.
Adiponectin receptor signaling: a new layer to the current model.
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Takemoto D, Kamakura S, Saikia S, Becker Y, Wrenn R, Tanaka A, Sumimoto H, Scott B.
Polarity proteins Bem1 and Cdc24 are components of the filamentous fungal NADPH oxidase complex.
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Ihara M, Matsuura N, Yamashita A.
High-resolution Native-PAGE for membrane proteins capable of fluorescence detection and hydrodynamic-state evaluation.
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Ibuki T, Imada K, Minamino T, Kato T, Miyata T, Namba K.
Common architecture of the flagellar type III protein export apparatus and F- and V-type ATPases.
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Nakagawa Y, Takamatsu H, Okuno T, Kang S, Nojima S, Kimura T, Kataoka TR, Ikawa M, Toyofuku T, Katayama I, Kumanogoh A.
Identification of Semaphorin 4B as a Negative Regulator of Basophil-Mediated Immune Responses.
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Selim KB, Nakanishi H, Matsumoto Y, Yamamoto Y, Yamada K, Tomioka K.
Chiral N-Heterocyclic Carbene-Copper(I)-Catalyzed Asymmetric Allylic Arylation of Aliphatic Allylic Bromides: Steric and Electronic Effects on γ-Selectivity.
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Awakawa T, Fujita N, Hayakawa M, Ohnishi Y, Horinouchi S.
Characterization of the Biosynthesis Gene Cluster for Alkyl-O-Dihydrogeranyl-Methoxyhydroquinones in Actinoplanes missouriensis.
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Maruyama Y, Chuma A, Mikami B, Hashimoto W, Murata K.
Heterosubunit composition and crystal structures of a novel bacterial M16B metallopeptidase.
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Hirano K, Inaba Y, Takahashi N, Shimano M, Oishi S, Fujii N, Ohno H.
Direct Synthesis of Fused Indoles by Gold-Catalyzed Cascade Cyclization of Diynes.
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Taguchi K, Motohashi H, Yamamoto M.
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
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Masuda S, Oda Y, Sasaki H, Ikenouchi J, Higashi T, Akashi M, Nishi E, Furuse M.
LSR defines cell corners for tricellular tight junction formation in epithelial cells.
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Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, Ishitani R, Takagi J, Aoki J, Nureki O.
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators.
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Man Z, Kondo Y, Koga H, Umino H, Nakayama K, Shin HW.
Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs.
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Takeda M, Hallenga K, Shigezane M, Waelchli M, Löhr F, Markley JL, Kainosho M.
Construction and performance of an NMR tube with a sample cavity formed within magnetic susceptibility-matched glass.
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Matsuzaki K.
Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters.
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Maruyama Y, Ochiai A, Mikami B, Hashimoto W, Murata K.
Crystal structure of bacterial cell-surface alginate-binding protein with an M_75 peptidase motif.
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Sonoda Y, Newstead S, Hu NJ, Alguel Y, Nji E, Beis K, Yashiro S, Lee C, Leung J, Cameron AD, Byrne B, Iwata S, Drew D.
Benchmarking Membrane Protein Detergent Stability for Improving Throughput of High-Resolution X-ray Structures.
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Horikoshi N, Tachiwana H, Saito K, Osakabe A, Sato M, Yamada M, Akashi S, Nishimura Y, Kagawa W, Kurumizaka H.
Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene.
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Obara K, Ohsumi Y.
PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast.
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Hayashi A, Hino N, Kobayashi T, Arai R, Shirouzu M, Yokoyama S, Sakamoto K.
Dissecting Cell Signaling Pathways with Genetically Encoded 3-Iodo-L-tyrosine.
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Esaki K, Terashima Y, Toda E, Yoshinaga S, Araki N, Matsushima K, Terasawa H.
Expression and purification of human FROUNT, a common cytosolic regulator of CCR2 and CCR5.
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Ohashi-Suzuki M, Yabu Y, Ohshima S, Nakamura K, Kido Y, Sakamoto K, Kita K, Ohta N, Suzuki T.
Differential Kinetic Activities of Glycerol Kinase among African Trypanosome Species: Phylogenetic and Therapeutic Implications.
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Hino N, Oyama M, Sato A, Mukai T, Iraha F, Hayashi A, Kozuka-Hata H, Yamamoto T, Yokoyama S, Sakamoto K.
Genetic incorporation of a photo-crosslinkable amino acid reveals novel protein complexes with GRB2 in mammalian cells.
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Inoue D, Kubo H, Taguchi K, Suzuki T, Komatsu M, Motohashi H, Yamamoto M.
Inducible disruption of autophagy in the lung causes airway hyper-responsiveness.
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Suzuki T, Maher J, Yamamoto M.
Select Heterozygous Keap1 Mutations Have a Dominant-negative Effect on Wild-type Keap1 In Vivo.
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Ogasawara M, Sasaki M, Nakazawa N, Nishino A, Okamura Y.
Gene expression profile of Ci-VSP in juveniles and adult blood cells of ascidian.
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Ebina T, Toh H, Kuroda Y.
DROP: An SVM domain linker predictor trained with optimal features selected by random forest.
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Urano N, Fukui S, Kumashiro S, Ishige T, Kita S, Sakamoto K, Kataoka M, Shimizu S.
Directed evolution of an aminoalcohol dehydrogenase for efficient production of double chiral aminoalcohols.
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Mikiya Otsuji, Yuya Terashima, Shuji Ishihara, Shinya Kuroda, Kouji Matsushima
A Conceptual Molecular Network for Chemotactic Behaviors Characterized by Feedback of Molecules Cycling Between the Membrane and the Cytosol
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Umeda N, Ueno T, Pohlmeyer C, Nagano T, Inoue T.
A Photocleavable Rapamycin Conjugate for Spatiotemporal Control of Small GTPase Activity.
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Niijima S, Yabuuchi H, Okuno Y.
Cross-Target View to Feature Selection: Identification of Molecular Interaction Features in Ligand-Target Space.
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Katsuyama Y, Miyazono KI, Tanokura M, Ohnishi Y, Horinouchi S.
Structural and biochemical elucidation of mechanism for decarboxylative condensation of beta-keto acid by curcumin synthase.
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Yoshihara K, Ikenouchi J, Izumi Y, Akashi M, Tsukita S, Furuse M.
Phosphorylation state regulates the localization of Scribble at adherens junctions and its association with E-cadherin-catenin complexes.
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Nakamichi Y, Maruyama Y, Mikami B, Hashimoto W, Murata K.
Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups.
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Ohashi M, Oyama T, Nakagome I, Satoh M, Nishio Y, Nobusada H, Hirono S, Morikawa K, Hashimoto Y, Miyachi H.
Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPARG-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship.
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Sato S, Mimasu S, Sato A, Hino N, Sakamoto K, Umehara T, Yokoyama S.
Crystallographic study of a site-specifically crosslinked protein complex with a genetically incorporated photo-reactive amino acid.
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Kubori T, Shinzawa N, Kanuka H, Nagai H.
Legionella metaeffector exploits host proteasome to temporally regulate cognate effector.
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Nagashima A, Touhara K.
Enzymatic conversion of odorants in nasal mucus affects olfactory glomerular activation patterns and odor perception.
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Terauchi T, Kamikawai T, Vinogradov MG, Starodubtseva EV, Takeda M, Kainosho M.
Synthesis of Stereoarray Isotope Labeled (SAIL) Lysine via the "Head-to-Tail" Conversion of SAIL Glutamic Acid.
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Khan MM, Siro S, Lai S, Kawatani M, Shimizu T, Osada H.
Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.
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Tagami S, Sekine S, Kumarevel T, Hino N, Murayama Y, Kamegamori S, Yamamoto M, Sakamoto K, Yokoyama S.
Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein.
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Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T.
Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the {gamma}-Secretase.
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Yamamoto Y, Hirai T, Yamamoto E, Kawamura M, Sato T, Kitano H, Matsuoka M, Ueguchi-Tanaka M.
A Rice gid1 Suppressor Mutant Reveals That Gibberellin Is Not Always Required for Interaction between Its Receptor, GID1, and DELLA Proteins.
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Sato Y, Shibata H, Nakatsu T, Nakano H, Kashiwayama Y, Imanaka T, Kato H.
Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.
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Kobashigawa Y, Harada K, Yoshida N, Ogura K, Inagaki F.
Phosphoinositide-incorporated lipid-protein Nanodiscs: A tool for studying protein-lipid interactions.
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Noguchi A, Horinouchi S, Ohnishi Y.
Substrate specificity of benzamide synthetase involved in 4-hydroxy-3-nitrosobenzamide biosynthesis.
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Kamisaki H, Nanjo T, Tsukano C, Takemoto Y.
Domino Pd-Catalyzed Heck Cyclization and Bismuth-Catalyzed Hydroamination: Formal Synthesis of Elacomine and Isoelacomine.
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Yao XQ, Kenzaki H, Murakami S, Takada S.
Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations.
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Yamashita S, Nagata T, Kawazoe M, Takemoto C, Kigawa T, Güntert P, Kobayashi N, Terada T, Shirouzu M, Wakiyama M, Muto Y, Yokoyama S.
Structures of the first and second double-stranded RNA-binding domains of human TAR RNA-binding protein.
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Yoshida K, Inokuma T, Takasu K, Takemoto Y.
Catalytic asymmetric synthesis of both enantiomers of 4 substituted 1,4-dihydropyridines with the use of bifunctional thiourea-ammonium salts bearing different counterions.
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Takasu K, Azuma T, Enkhtaivan I, Takemoto Y.
Synthesis and properties of chiral thioureas bearing an additional function at a remote position tethered by a 1,5-disubstituted triazole.
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Okamoto M, Saito N, Kojima H, Okabe T, Takeda K, Ichijo H, Furuya T, Nagano T.
Identification of novel ASK1 inhibitors using virtual screening.
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Ogawa J, Kodera T, Smirnov SV, Hibi M, Samsonova NN, Koyama R, Yamanaka H, Mano J, Kawashima T, Yokozeki K, Shimizu S.
A novel L-isoleucine metabolism in Bacillus thuringiensis generating (2S,3R,4S)-4-hydroxyisoleucine, a potential insulinotropic and anti-obesity amino acid.
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Uemura T, Morita MT, Ebine K, Okatani Y, Yano D, Saito C, Ueda T, Nakano A.
Vacuolar/pre-vacuolar compartment Qa-SNAREs VAM3/SYP22 and PEP12/SYP21 have interchangeable functions in Arabidopsis.
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Suzuki T, Nagao A, Suzuki T.
Human Mitochondrial tRNAs: Biogenesis, Function, Structural Aspects, and Diseases.
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Chavas LM, Yamada Y, Hiraki M, Igarashi N, Matsugaki N, Wakatsuki S.
UV LED lighting for automated crystal centring.
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Wierzba K, Muroi M, Osada H.
Proteomics accelerating the identification of the target molecule of bioactive small molecules.
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Tsuchiya S, Fujiwara T, Sato F, Shimada Y, Tanaka E, Sakai Y, Shimizu K, Tsujimoto G.
MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1).
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Mizushima N, Yoshimori T, Ohsumi Y.
The Role of Atg Proteins in Autophagosome Formation.
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Nagao A, Mituyama T, Huang H, Chen D, Siomi MC, Siomi H.
Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis.
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Kiyose K, Hanaoka K, Oushiki D, Nakamura T, Kajimura M, Suematsu M, Nishimatsu H, Yamane T, Terai T, Hirata Y, Nagano T.
Hypoxia-Sensitive Fluorescent Probes for in Vivo Real-Time Fluorescence Imaging of Acute Ischemia.
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Umezawa T, Nakashima K, Miyakawa T, Kuromori T, Tanokura M, Shinozaki K, Yamaguchi-Shinozaki K.
Molecular basis of the core regulatory network in abscisic acid responses: sensing, signaling, and transport.
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Yamamoto Y, Mochida S, Miyazaki N, Kawai K, Fujikura K, Kurooka T, Iwasaki K, Sakisaka T.
Tomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats.
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Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M.
Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia.
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Saito K, Kobayashi K, Wada M, Kikuno I, Takusagawa A, Mochizuki M, Uchiumi T, Ishitani R, Nureki O, Ito K.
Omnipotent role of archaeal elongation factor 1 alpha (EF1{alpha}) in translational elongation and termination, and quality control of protein synthesis.
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Motohashi H, Fujita R, Takayama M, Inoue A, Katsuoka F, Bresnick EH, Yamamoto M.
Molecular Determinants for Small Maf Protein Control of Platelet Production.
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Kato M, Araiso Y, Noma A, Nagao A, Suzuki T, Ishitani R, Nureki O.
Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.
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Homma K, Suzuki K, Sugawara H.
The Autophagy Database: an all-inclusive information resource on autophagy that provides nourishment for research.
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Minami A, Mizutani K, Waseda M, Kajita M, Miyata M, Ikeda W, Takai Y.
Necl-5/PVR enhances PDGF-induced attraction of growing microtubules to the plasma membrane of the leading edge of moving NIH3T3 cells.
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Urano N, Kataoka M, Ishige T, Kita S, Sakamoto K, Shimizu S.
Genetic analysis around aminoalcohol dehydrogenase gene of Rhodococcus erythropolis MAK154: a putative GntR transcription factor in transcriptional regulation.
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Hashimoto H, Hara K, Hishiki A, Kawaguchi S, Shichijo N, Nakamura K, Unzai S, Tamaru Y, Shimizu T, Sato M.
Crystal structure of zinc-finger domain of Nanos and its functional implications.
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Kimoto M, Mitsui T, Yamashige R, Sato A, Yokoyama S, Hirao I.
A New Unnatural Base Pair System between Fluorophore and Quencher Base Analogues for Nucleic Acid-Based Imaging Technology.
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Kawaguchi M, Okabe T, Terai T, Hanaoka K, Kojima H, Minegishi I, Nagano T.
A Time-Resolved Fluorescence Probe for Dipeptidyl Peptidase 4 and Its Application in Inhibitor Screening.
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Ito K, Sugawara T, Koizumi A, Nakajima KI, Shimizu-Ibuka A, Shiroishi M, Asada H, Yurugi-Kobayashi T, Shimamura T, Asakura T, Misaka T, Iwata S, Kobayashi T, Abe K.
Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein.
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Nakano N, Kubori T, Kinoshita M, Imada K, Nagai H.
Crystal structure of Legionella DotD: insights into the relationship between type IVB and type II/III secretion systems.
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Miyazono KI, Um J, Imai FL, Katsuyama Y, Ohnishi Y, Horinouchi S, Tanokura M.
Crystal structure of curcuminoid synthase CUS from Oryza sativa.
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Nishitani Y, Yoshida S, Fujihashi M, Kitagawa K, Doi T, Atomi H, Imanaka T, Miki K.
Structure-based catalytic optimization of a type III Rubisco from a hyperthermophile.
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Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J.
Structural basis for semaphorin signalling through the plexin receptor.
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Ito T, Yokoyama S.
Two enzymes bound to one transfer RNA assume alternative conformations for consecutive reactions.
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Kobayashi K, Kikuno I, Kuroha K, Saito K, Ito K, Ishitani R, Inada T, Nureki O.
Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1{alpha} complex.
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Sherrer RL, Araiso Y, Aldag C, Ishitani R, Ho JM, Söll D, Nureki O.
C-terminal domain of archaeal O-phosphoseryl-tRNA kinase displays large-scale motion to bind the 7-bp D-stem of archaeal tRNASec.
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Tsuji H, Taoka KI, Shimamoto K.
Regulation of flowering in rice: two florigen genes, a complex gene network, and natural variation.
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Ch'ng ES, Kumanogoh A.
Roles of Sema4D and Plexin-B1 in tumor progression.
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Suzuki N, Hiraki M, Yamada Y, Matsugaki N, Igarashi N, Kato R, Dikic I, Drew D, Iwata S, Wakatsuki S, Kawasaki M.
Crystallization of small proteins assisted by green fluorescent protein.
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Goshima Y, Usui H, Shiozawa T, Hida T, Kuraoka S, Takeshita S, Yamashita N, Ichikawa Y, Kamiya Y, Gotoh T, Gotoh T.
Computational Analysis of the Effects of Antineoplastic Agents on Axonal Transport.
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Ueguchi-Tanaka M, Matsuoka M.
The perception of gibberellins: clues from receptor structure.
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Nogawa T, Okano A, Takahashi S, Uramoto M, Konno H, Saito T, Osada H.
Verticilactam, a New Macrolactam Isolated from a Microbial Metabolite Fraction Library.
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Sakurai M, Yano T, Kawabata H, Ueda H, Suzuki T.
Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome.
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Uejima T, Ihara K, Goh T, Ito E, Sunada M, Ueda T, Nakano A, Wakatsuki S.
GDP-bound and nucleotide-free intermediates of the guanine nucleotide exchange in the Rab5/Vps9 system.
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Katsuyama Y, Ohnishi Y, Horinouchi S.
Production of Dehydrogingerdione Derivatives in Escherichia coli by Exploiting a Curcuminoid Synthase from Oryza sativa and a beta-Oxidation Pathway from Saccharomyces cerevisiae.
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Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Côté JF, Nagasawa T, Fukui Y.
DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4.
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He F, Umehara T, Saito K, Harada T, Watanabe S, Yabuki T, Kigawa T, Takahashi M, Kuwasako K, Tsuda K, Matsuda T, Aoki M, Seki E, Kobayashi N, Güntert P, Yokoyama S, Muto Y.
Structural Insight into the Zinc Finger CW Domain as a Histone Modification Reader.
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Yamada K, Sato T, Hosoi M, Yamamoto Y, Tomioka K.
Stereoselective Formal Synthesis of (+)-Allokainic Acid via Thiol-Mediated Acyl Radical Cyclization.
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Madono M, Sawasaki T, Morishita R, Endo Y.
Wheat germ cell-free protein production system for post-genomic research.
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Kinjo AR, Yamashita R, Nakamura H.
PDBj Mine: design and implementation of relational database interface for Protein Data Bank Japan.
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Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T.
Expanding role of the Jumonji C domain as an RNA hydroxylase.
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Kasuga JI, Ishikawa M, Yonehara M, Makishima M, Hashimoto Y, Miyachi H.
Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry.
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Yanagisawa T, Sumida T, Ishii R, Takemoto C, Yokoyama S.
A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P.
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Ogawa H, Shionyu M, Sugiura N, Hatano S, Nagai N, Kubota Y, Nishiwaki K, Sato T, Gotoh M, Narimatsu H, Shimizu K, Kimata K, Watanabe H.
Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function.
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Satoh T, Sakata E, Yamamoto S, Yamaguchi Y, Sumiyoshi A, Wakatsuki S, Kato K.
Crystal structure of cyclic Lys48-linked tetraubiquitin.
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Hirano K, Asano K, Tsuji H, Kawamura M, Mori H, Kitano H, Ueguchi-Tanaka M, Matsuoka M.
Characterization of the Molecular Mechanism Underlying Gibberellin Perception Complex Formation in Rice.
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Miyazaki I, Simizu S, Okumura H, Takagi S, Osada H.
A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.
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Matsuda M, Yamashita JK, Tsukita S, Furuse M.
abLIM3 is a novel component of adherens junctions with actin-binding activity.
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Chiba S, Itoh Y, Sekine SI, Yokoyama S.
Structural Basis for the Major Role of O-Phosphoseryl-tRNA Kinase in the UGA-Specific Encoding of Selenocysteine.
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Ohta Y, Tokimizu Y, Oishi S, Fujii N, Ohno H.
Direct Synthesis of Quinazolines through Copper-Catalyzed Reaction of Aniline-Derived Benzamidines.
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Mukai T, Hayashi A, Iraha F, Sato A, Ohtake K, Yokoyama S, Sakamoto K.
Codon reassignment in the Escherichia coli genetic code.
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Sun Q, Hirasawa A, Hara T, Kimura I, Adachi T, Awaji T, Ishiguro M, Suzuki T, Miyata N, Tsujimoto G.
Structure-activity relationships of GPR120 agonists based on a docking simulation.
-
Nakamura K, Fujioka S, Fukumoto S, Inoue N, Sakamoto K, Hirata H, Kido Y, Yabu Y, Suzuki T, Watanabe YI, Saimoto H, Akiyama H, Kita K.
Trypanosome alternative oxidase, a potential therapeutic target for sleeping sickness, is conserved among Trypanosoma brucei subspecies.
-
Maehara Y, Miyano K, Yuzawa S, Akimoto R, Takeya R, Sumimoto H.
A Conserved region between the TPR and activation domains of p67phox participates in activation of the phagocyte NADPH oxidase.
-
Noguchi A, Kitamura T, Onaka H, Horinouchi S, Ohnishi Y.
A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis.
-
Kawano S, Mizutani K, Miyata M, Ikeda W, Takai Y.
Interaction of integrin alphabeta with ErbB3 and implication in heregulin-induced ErbB3/ErbB2-mediated DNA synthesis.
-
Yamauchi S, Fusada N, Hayashi H, Utsumi T, Uozumi N, Endo Y, Tozawa Y.
The consensus motif for N-myristoylation of plant proteins in a wheat germ cell-free translation system.
-
Takakura H, Sasakura K, Ueno T, Urano Y, Terai T, Hanaoka K, Tsuboi T, Nagano T.
Development of Luciferin Analogues Bearing an Amino Group and Their Application as BRET Donors.
-
Watanabe Y, Noda NN, Kumeta H, Suzuki K, Ohsumi Y, Inagaki F.
Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by ATG19 and ATG34.
-
Johansson F, Toh H.
A comparative study of conservation and variation scores.
-
Shimoyama S, Nagadoi A, Tachiwana H, Yamada M, Sato M, Kurumizaka H, Akashi S, Nishimura Y.
Deimination stabilizes histone H2A/H2B dimers as revealed by electrospray ionization mass spectrometry.
-
Suzuki K, Kondo C, Morimoto M, Ohsumi Y.
Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, ATG34.
-
Yamamoto Y, Fujikura K, Sakaue M, Okimura K, Kobayashi Y, Nakamura T, Sakisaka T.
The tail domain of tomosyn controls membrane fusion through tomosyn displacement by VAMP2.
-
Coban C, Horii T, Akira S, Ishii KJ.
TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine.
-
Yamaguchi M, Noda NN, Nakatogawa H, Kumeta H, Ohsumi Y, Inagaki F.
Autophagy-related protein (Atg) 8-family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway.
-
Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H.
Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.
-
Nureki O, O'Donoghue P, Watanabe N, Ohmori A, Oshikane H, Araiso Y, Sheppard K, Söll D, Ishitani R.
Structure of an archaeal non-discriminating glutamyl-tRNA synthetase: a missing link in the evolution of Gln-tRNAGln formation.
-
Okatsu K, Saisho K, Shimanuki M, Nakada K, Shitara H, Sou YS, Kimura M, Sato S, Hattori N, Komatsu M, Tanaka K, Matsuda N.
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria.
-
Miyoshi K, Miyoshi T, Siomi H.
Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production.
-
Todokoro Y, Kobayashi M, Sato T, Kawakami T, Yumen I, Aimoto S, Fujiwara T, Akutsu H.
Structure analysis of membrane-reconstituted subunit c-ring of E. coli H(+)-ATP synthase by solid-state NMR.
-
Wakamori M, Umehara T, Yokoyama S.
A series of bacterial co-expression vectors with rare-cutter recognition sequences.
-
Kuratani M, Hirano M, Goto-Ito S, Itoh Y, Hikida Y, Nishimoto M, Sekine SI, Bessho Y, Ito T, Grosjean H, Yokoyama S.
Crystal Structure of Methanocaldococcus jannaschii Trm4 complexed with sinefungin.
-
Haga S, Hattori T, Sato T, Sato K, Matsuda S, Kobayakawa R, Sakano H, Yoshihara Y, Kikusui T, Touhara K.
The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor.
-
Maruyama Y, Ochiai A, Itoh T, Mikami B, Hashimoto W, Murata K.
Mutational studies of the peptidoglycan hydrolase FlgJ of Sphingomonas sp. strain A1.
-
Fukunishi Y, Ohno K, Orita M, Nakamura H.
Selection of In Silico Drug Screening Results by Using Universal Active Probes (UAPs).
-
Hikida Y, Kimoto M, Yokoyama S, Hirao I.
Site-specific fluorescent probing of RNA molecules by unnatural base-pair transcription for local structural conformation analysis.
-
Matsuoka K, Komori H, Nose M, Endo Y, Sawasaki T.
A simple screening method for autoantigen proteins using the N-terminal biotinylated protein library produced by wheat cell-free synthesis.
-
Mimasu S, Umezawa N, Sato S, Higuchi T, Umehara T, Yokoyama S.
Structurally Designed Trans-2-phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1.
-
Ito T, Kiyasu N, Matsunaga R, Takahashi S, Yokoyama S.
Structure of nondiscriminating glutamyl-tRNA synthetase from Thermotoga maritima.
-
Yogo T, Urano Y, Kamiya M, Sano K, Nagano T.
Development of enzyme-activated photosensitizer based on intramolecular electron transfer.
-
Enomoto T, Yasui Y, Takemoto Y.
Synthetic Study toward Ecteinascidin 743: Concise Construction of the Diazabicyclo[3.3.1]nonane Skeleton and Assembly of the Pentacyclic Core.
-
Kumanogoh A, Kikutani H.
Semaphorins and their receptors: novel features of neural guidance molecules.
-
Ogita H, Rikitake Y, Miyoshi J, Takai Y.
Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology.
-
Saitoh T, Akira S.
Regulation of innate immune responses by autophagy-related proteins.
-
Okano A, Tsukamoto K, Kosaka S, Maeda H, Oishi S, Tanaka T, Fujii N, Ohno H.
Synthesis of Fused and Linked Bicyclic Nitrogen Heterocycles by Palladium-Catalyzed Domino Cyclization of Propargyl Bromides.
-
Takasu K, Nagamoto Y, Takemoto Y.
Stereocontrolled Synthesis of Spiro[n.2]alkenes by Ring Contraction of Fused-Cyclobutanols.
-
Sasaki H, Hanaoka K, Urano Y, Terai T, Nagano T.
Design and synthesis of a novel fluorescence probe for Zn(2+) based on the spirolactam ring-opening process of rhodamine derivatives.
-
Makino SI, Sawasaki T, Endo Y, Takai K.
In vitro dissection revealed that the kinase domain of wheat RNA ligase is physically isolatable from the flanking domains as a non-overlapping domain enzyme.
-
Yamamoto H, Koga H, Katoh Y, Takahashi S, Nakayama K, Shin HW.
Functional Crosstalk between Rab14 and Rab4 through a Dual Effector, RUFY1/Rabip4.
-
Tochio N, Umehara T, Munemasa Y, Suzuki T, Sato S, Tsuda K, Koshiba S, Kigawa T, Nagai R, Yokoyama S.
Solution structure of histone chaperone ANP32B: Interaction with core histones H3-H4 through its acidic concave domain.
-
Osada H.
Introduction of New Tools for Chemical Biology Research on Microbial Metabolites.
-
Matsunaga S, Matsuoka K, Shimizu K, Endo Y, Sawasaki T.
Biotinylated-sortase self-cleavage purification (BISOP) method for cell-free produced proteins.
-
Oishi S, Watanabe T, Sawada JI, Asai A, Ohno H, Fujii N.
Kinesin Spindle Protein (KSP) Inhibitors with 2,3-Fused Indole Scaffolds.
-
Mitome N, Ono S, Sato H, Suzuki T, Sone N, Yoshida M.
Essential Arg of Fo-a subunit in FoF1-ATP synthase has a role to prevent the proton shortcut without c-ring rotation in the Fo proton channel.
-
Matsuki Y, Takahashi H, Ueda K, Idehara T, Ogawa I, Toda M, Akutsu H, Fujiwara T.
Dynamic nuclear polarization experiments at 14.1 T for solid-state NMR.
-
Nakano A, Luini A.
Passage through the Golgi.
-
Tabata S, Nampo M, Mihara E, Tamura-Kawakami K, Fujii I, Takagi J.
A rapid screening method for cell lines producing singly-tagged recombinant proteins using the "TARGET tag" system.
-
Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT Jr, Raman V, Ebina M, Nukiwa T, Yamamoto M.
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung.
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Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel RH, Rayburn H, Tessier-Lavigne M, Yoshida Y, Okuno T, Mizui M, Kang S, Nojima S, Tsujimura T, Nakatsuji Y, Katayama I, Toyofuku T, Kikutani H, Kumanogoh A.
Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.
-
Muroi M, Kazami S, Noda K, Kondo H, Takayama H, Kawatani M, Usui T, Osada H.
Application of Proteomic Profiling Based on 2D-DIGE for Classification of Compounds According to the Mechanism of Action.
-
Takase R, Ochiai A, Mikami B, Hashimoto W, Murata K.
Molecular identification of unsaturated uronate reductase prerequisite for alginate metabolism in Sphingomonas sp. A1.
-
Ochiai A, Yamasaki M, Mikami B, Hashimoto W, Murata K.
Crystal structure of exotype alginate lyase Atu3025 from agrobacterium tumefaciens.
-
Patil A, Kinoshita K, Nakamura H.
Domain distribution and intrinsic disorder in hubs in the human protein-protein interaction network.
-
Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S.
PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis.
-
Nakanaga K, Hama K, Aoki J.
Autotaxin - an LPA producing enzyme with diverse functions.
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Kodama K, Nakayama H, Sakamoto K, Fukuzawa S, Kigawa T, Yabuki T, Kitabatake M, Takio K, Yokoyama S.
Site-specific Incorporation of 4-Iodo-L-phenylalanine through Opal Suppression.
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Kawano Y, Akamatsu A, Hayashi K, Housen Y, Okuda J, Yao A, Nakashima A, Takahashi H, Yoshida H, Wong HL, Kawasaki T, Shimamoto K.
Activation of a Rac GTPase by the NLR Family Disease Resistance Protein Pit Plays a Critical Role in Rice Innate Immunity.
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Shima F, Ijiri Y, Muraoka S, Liao J, Ye M, Araki M, Matsumoto K, Yamamoto N, Sugimoto T, Yoshikawa Y, Kumasaka T, Yamamoto M, Tamura A, Kataoka T.
Structural basis for conformational dynamics of GTP-bound Ras protein.
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Higashiura A, Kurakane T, Matsuda M, Suzuki M, Inaka K, Sato M, Kobayashi T, Tanaka T, Tanaka H, Fujiwara K, Nakagawa A.
High-resolution X-ray crystal structure of bovine H-protein at 0.88 A resolution.
-
Siomi H, Siomi MC.
Posttranscriptional regulation of microRNA biogenesis in animals.
-
Fukunaga K, Kudo T, Toh-E A, Tanaka K, Saeki Y.
Dissection of the assembly pathway of the proteasome lid in Saccharomyces cerevisiae.
-
Inuki S, Yoshimitsu Y, Oishi S, Fujii N, Ohno H.
Ring-Construction/Stereoselective Functionalization Cascade: Total Synthesis of Pachastrissamine (Jaspine B) through Palladium-Catalyzed Bis-cyclization of Propargyl Chlorides and Carbonates.
-
Itoh K, Mimura J, Yamamoto M.
Discovery of the negative regulator of Nrf2, Keap1: A historical overview.
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Matsuzawa M, Katsuyama Y, Funa N, Horinouchi S.
Alkylresorcylic acid synthesis by type III polyketide synthases from rice Oryza sativa.
-
Kumasaka T, Shimizu N, Baba S, Hasegawa K, Ueno G, Yamamoto M.
SPring-8 structural biology beamline.
-
Yamamoto M, Hirata K, Hikima T, Kawano Y, Ueno G.
Protein micro-crystallography with a new micro-beam beamline.
-
Wakatsuki S, Yamada Y, Chavas LM, Igarashi N, Kawasaki M, Kato R, Hiraki M, Matsugaki N.
Advancement of synchrotron radiation protein crystallography aimed by the targeted protein research program: beamline developments at the photon factory.
-
Kumeta H, Watanabe M, Nakatogawa H, Yamaguchi M, Ogura K, Adachi W, Fujioka Y, Noda NN, Ohsumi Y, Inagaki F.
The NMR structure of the autophagy-related protein Atg8.
-
Yoshiura C, Kofuku Y, Ueda T, Mase Y, Yokogawa M, Osawa M, Terashima Y, Matsushima K, Shimada I.
NMR Analyses of the Interaction between CCR5 and Its Ligand Using Functional Reconstitution of CCR5 in Lipid Bilayers.
-
Patil A, Kinoshita K, Nakamura H.
Hub promiscuity in protein-protein interaction networks.
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Imada K, Minamino T, Kinoshita M, Furukawa Y, Namba K.
Structural insight into the regulatory mechanisms of interactions of the flagellar type III chaperone FliT with its binding partners.
-
Tsutsui H, Higashijima SI, Miyawaki A, Okamura Y.
Visualizing Voltage Dynamics in Zebrafish Heart.
-
Kinjo AR, Nakamura H.
Geometric similarities of protein-protein interfaces at atomic resolution are only observed within homologous families: an exhaustive structural classification study.
-
Watanabe N, Takagi S, Tominaga A, Tomita T, Iwatsubo T.
Functional analysis of the transmembrane domains of presenilin 1: Participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of {gamma}-secretase.
-
Kimura Y, Tanaka K.
Regulatory mechanisms involved in the control of ubiquitin homeostasis.
-
Shimamura T, Weyand S, Beckstein O, Rutherford NG, Hadden JM, Sharples D, Sansom MS, Iwata S, Henderson PJ, Cameron AD.
Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1
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Okudaira S, Yukiura H, Aoki J.
Biological roles of lysophosphatidic acid signaling through its production by autotaxin.
-
Tawa H, Rikitake Y, Takahashi M, Amano H, Miyata M, Satomi-Kobayashi S, Kinugasa M, Nagamatsu Y, Majima T, Ogita H, Miyoshi J, Hirata KI, Takai Y.
Role of Afadin in Vascular Endothelial Growth Factor- and Sphingosine 1-Phosphate-Induced Angiogenesis.
-
Yoshimitsu Y, Inuki S, Oishi S, Fujii N, Ohno H.
Stereoselective Divergent Synthesis of Four Diastereomers of Pachastrissamine (Jaspine B).
-
Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, Tanaka K.
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
-
Taguchi K, Maher JM, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M.
Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1.
-
Ohto C, Muramatsu M, Obata S, Sakuradani E, Shimizu S.
Production of geranylgeraniol on overexpression of a prenyl diphosphate synthase fusion gene in Saccharomyces cerevisiae.
-
Kumagai Y, Akira S.
Identification and functions of pattern-recognition receptors.
-
Miyazono KI, Zhi Y, Takamura Y, Nagata K, Saigo K, Kojima T, Tanokura M.
Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.
-
Muramoto K, Ohta K, Shinzawa-Itoh K, Kanda K, Taniguchi M, Nabekura H, Yamashita E, Tsukihara T, Yoshikawa S.
Bovine cytochrome c oxidase structures enable O2 reduction with minimization of reactive oxygens and provide a proton-pumping gate.
-
Sonoda Y, Cameron A, Newstead S, Omote H, Moriyama Y, Kasahara M, Iwata S, Drew D.
Tricks of the trade used to accelerate high-resolution structure determination of membrane proteins.
-
Takeda M, Jee J, Terauchi T, Kainosho M.
Detection of the Sulfhydryl Groups in Proteins with Slow Hydrogen Exchange Rates and Determination of Their Proton/Deuteron Fractionation Factors Using the Deuterium-Induced Effects on the (13)C(beta) NMR Signals.
-
Kainosho M, Guntert P.
SAIL - stereo-array isotope labeling.
-
Katayama Y, Shimokata K, Suematsu M, Ogura T, Tsukihara T, Yoshikawa S, Shimada H.
Cell-free synthesis of cytochrome c oxidase, a multicomponent membrane protein.
-
Sakaguchi M, Shinzawa-Itoh K, Yoshikawa S, Ogura T.
A resonance Raman band assignable to the O-O stretching mode in the resting oxidized state of bovine heart cytochrome c oxidase.
-
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T.
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca2+ and AMPK/SIRT1.
-
Koyama S, Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S, Ishii KJ.
Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.
-
Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M.
Genetic Analysis of Hierarchical Regulation for Gata1 and NF-E2 p45 Gene Expression in Megakaryopoiesis.
-
Mikami S, Kobayashi T, Machida K, Masutani M, Yokoyama S, Imataka H.
N-terminally truncated GADD34 proteins are convenient translation enhancers in a human cell-derived in vitro protein synthesis system.
-
Takahashi S, Takagi H, Toyoda A, Uramoto M, Nogawa T, Ueki M, Sakaki Y, Osada H.
Biochemical Characterization of a Novel Indole Prenyltransferase from Streptomyces sp. SN-593.
-
Kimoto M, Mitsui T, Yokoyama S, Hirao I.
A Unique Fluorescent Base Analogue for the Expansion of the Genetic Alphabet.
-
Yanagihara I, Nakahira K, Yamane T, Kaieda S, Mayanagi K, Hamada D, Fukui T, Ohnishi K, Kajiyama S, Shimizu T, Sato M, Ikegami T, Ikeguchi M, Honda T, Hashimoto H.
Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin (TDH).
-
Takeuchi O, Akira S.
Pattern Recognition Receptors and Inflammation.
-
Saio T, Yokochi M, Kumeta H, Inagaki F.
PCS-based structure determination of protein-protein complexes.
-
Ichimura A, Ruike Y, Terasawa K, Shimizu K, Tsujimoto G.
MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cells.
-
Chen L, Hamada S, Fujiwara M, Zhu T, Thao NP, Wong HL, Krishna P, Ueda T, Kaku H, Shibuya N, Kawasaki T, Shimamoto K.
The Hop/Sti1-Hsp90 Chaperone Complex Facilitates the Maturation and Transport of a PAMP Receptor in Rice Innate Immunity.
-
Standley DM, Yamashita R, Kinjo AR, Toh H, Nakamura H.
SeSAW: balancing sequence and structural information in protein functional mapping.
-
Kim S, Saeki Y, Fukunaga K, Suzuki A, Takagi K, Yamane T, Tanaka K, Mizushima T, Kato K.
Crystal structure of yeast Rpn14, a chaperone of the 19S regulatory particle of the proteasome.
-
Mikuni J, Kato M, Taruya S, Tsuganezawa K, Mori M, Ogawa N, Honma T, Yokoyama S, Kojima H, Okabe T, Nagano T, Tanaka A.
A fluorescence correlation spectroscopy-based assay for fragment screening of slowly inhibiting protein-peptide interaction inhibitors.
-
Gotoh K, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Maeda N, Ishikawa T, Hoshino K, Uruno T, Cao Q, Higashi S, Kawaguchi Y, Enjoji M, Takayanagi R, Kaisho T, Yoshikai Y, Fukui Y.
Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.
-
Maki-Yonekura S, Yonekura K, Namba K.
Conformational change of flagellin for polymorphic supercoiling of the flagellar filament.
-
Tanaka Y, Mori Y, Tani H, Abe T, Moriishi K, Kojima H, Nagano T, Okabe T, Suzuki T, Tatsumi M, Matsuura Y.
Establishment of an indicator cell system for hepatitis C virus.
-
Nishiyama KI, Maeda M, Abe M, Kanamori T, Shimamoto K, Kusumoto S, Ueda T, Tokuda H.
A novel complete reconstitution system for membrane integration of the simplest membrane protein.
-
Kobayashi M, Akutsu H, Suzuki T, Yoshida M, Yagi H.
Analysis of the Open and Closed Conformations of the beta Subunits in Thermophilic F(1)-ATPase by Solution NMR.
-
Yasui N, Nogi T, Takagi J.
Structural Basis for Specific Recognition of Reelin by Its Receptors
-
Arakawa A, Handa N, Ohsawa N, Shida M, Kigawa T, Hayashi F, Shirouzu M, Yokoyama S.
The C-Terminal BAG Domain of BAG5 Induces Conformational Changes of the Hsp70 Nucleotide- Binding Domain for ADP-ATP Exchange.
-
Katsuyama Y, Hirose Y, Funa N, Ohnishi Y, Horinouchi S.
Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli.
-
Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J.
Estrogen inhibits TGF-beta signaling by promoting Smad2/3 degradation.
-
Chen L, Shiotani K, Togashi T, Miki D, Aoyama M, Wong HL, Kawasaki T, Shimamoto K.
Analysis of the Rac/Rop Small GTPase Family in Rice: Expression, Subcellular Localization and Role in Disease Resistance.
-
Chikayama E, Kurotani A, Tanaka T, Yabuki T, Miyazaki S, Yokoyama S, Kuroda Y.
Mathematical model for empirically optimizing large scale production of soluble protein domains.
-
Saijo-Hamano Y, Imada K, Minamino T, Kihara M, Shimada M, Kitao A, Namba K.
Structure of the cytoplasmic domain of FlhA and implication for flagellar type III protein export.
-
Ruike Y, Imanaka Y, Sato F, Shimizu K, Tsujimoto G.
Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing.
-
Nakatani M, Hibi M, Minoda M, Ogawa J, Yokozeki K, Shimizu S.
Two laccase isoenzymes and a peroxidase of a commercial laccase-producing basidiomycete, Trametes sp. Ha1.
-
Sasaki Y, Kataoka M, Urano N, Ogawa J, Iwasaki A, Hasegawa J, Isobe K, Shimizu S.
Cloning, sequencing and expression analysis of a gene encoding alcohol oxidase in Paenibacillus sp. AIU 311.
-
Shimada A, Takano K, Shirouzu M, Hanawa-Suetsugu K, Terada T, Toyooka K, Umehara T, Yamamoto M, Yokoyama S, Suetsugu S.
Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II
-
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motobayashi H, Tanaka K, Yamamoto M.
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
-
Iraha F, Oki K, Kobayashi T, Ohno S, Yokogawa T, Nishikawa K, Yokoyama S, Sakamoto K.
Functional replacement of the endogenous tyrosyl-tRNA synthetase-tRNATyr pair by the archaeal tyrosine pair in Escherichia coli for genetic code expansion.
-
Shida M, Arakawa A, Ishii R, Kishishita S, Takagi T, Kukimoto-Niino M, Sugano S, Tanaka A, Shirouzu M, Yokoyama S.
Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state.
-
Terakado K, Kodan A, Nakano H, Kimura Y, Ueda K, Nakatsu T, Kato H.
Deleting two C-terminal alpha-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP.
-
Saita EI, Iino R, Suzuki T, Feniouk BA, Kinosita K Jr, Yoshida M.
Activation and stiffness of the inhibited states of F1-ATPase probed by single-molecule manipulation.
-
Fujiwara T, Maisonneuve S, Isshiki M, Mizutani M, Chen L, Wong HL, Kawasaki T, Shimamoto K.
Sekiguchi lesion gene encodes a cytochrome p450 monooxygenase that catalyzes conversion of tryptamine to serotonin in rice.
-
Ikeuchi Y, Kimura S, Numata T, Nakamura D, Yokogawa T, Ogata T, Wada T, Suzuki T, Suzuki T.
Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea.
-
Matsumoto S.
Molecular Mechanisms Underlying Sex Pheromone Production in Moths.
-
Oushiki D, Kojima H, Terai T, Arita M, Hanaoka K, Urano Y, Nagano T.
Development and Application of a Near-Infrared Fluorescence Probe for Oxidative Stress Based on Differential Reactivity of Linked Cyanine Dyes.
-
Suzuki K, Ohsumi Y.
Current knowledge of the pre-autophagosomal structure (PAS).
-
Feniouk BA, Kato-Yamada Y, Yoshida M, Suzuki T.
Conformational Transitions of Subunit varepsilon in ATP Synthase from Thermophilic Bacillus PS3.
-
Takamatsu H, Okuno T, Kumanogoh A.
Regulation of immune cell responses by semaphorins and their receptors.
-
Akindele T, Yamada K, Sejima T, Maekawa M, Yamamoto Y, Nakano M, Tomioka K.
Stereoselective radical addition of an acetal to sterically tuned enantiomerically pure N-sulfinyl imines.
-
Wakiyama M, Kaitsu Y, Matsumoto T, Yokoyama S.
Coupled transcription-and-translation from PCR-amplified DNA in Drosophila S2 cell-free system.
-
Maher J, Yamamoto M.
The Rise of Antioxidant Signaling-The Evolution and Hormetic Actions of Nrf2.
-
Minamino T, Shimada M, Okabe M, Saijo-Hamano Y, Imada K, Kihara M, Namba K.
Role of the C-terminal cytoplasmic domain of FlhA in bacterial flagellar type III protein export.
-
Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, Yamamoto M.
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycinerepeat, and C-terminal domains.
-
Takai K, Sawasaki T, Endo Y.
Practical cell-free protein synthesis system using purified wheat embryos.
-
Coban C, Igari Y, Yagi M, Reimer T, Koyama S, Aoshi T, Ohata K, Tsukui T, Takeshita F, Sakurai K, Ikegami T, Nakagawa A, Horii T, Nunez G, Ishii KJ, Akira S.
Immunogenicity of whole parasite vaccines against Plasmodium Falciparum involves malarial hemozoin and host TLR9
-
Osakabe Y, Mizuno S, Tanaka H, Maruyama K, Osakabe K, Todaka D, Fujita Y, Kobayashi M, Shinozaki K, Yamaguchi-Shinozaki K.
Overproduction of the membrane-bound receptor-like protein kinase1, RPK1, enhances abiotic stress tolerance in Arabidopsis.
-
Yano Y, Shimai N, Matsuzaki K.
Design of a Soluble Transmembrane Helix for Measurements of Water-Membrane Partitioning.
-
Takahashi H, Kainosho M, Akutsu H, Fujiwara T.
(1)H-detected (1)H-(1)H correlation spectroscopy of a stereo-array isotope labeled amino acid under fast magic-angle spinning.
-
Noda NN, Ohsumi Y, Inagaki F.
Atg8-family interacting motif crucial for selective autophagy.
-
Siomi MC, Miyoshi T, Siomi H.
piRNA-mediated silencing in Drosophila germlines.
-
Sakata E, Satoh T, Yamamoto S, Yamaguchi Y, Yagi-Utsumi M, Kurimoto E, Tanaka K, Wakatsuki S, Kato K.
Crystal Structure of UbcH5b approximately Ubiquitin Intermediate: Insight into the Formation of the Self-Assembled E2 approximately Ub Conjugates.
-
Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O.
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
-
Mukai T, Wakiyama M, Sakamoto K, Yokoyama S.
Genetic encoding of non-natural amino acids in Drosophila melanogaster Schneider 2 cells.
-
Matsukura S, Mizoi J, Yoshida T, Todaka D, Ito Y, Maruyama K, Shinozaki K, Yamaguchi-Shinozaki K.
Comprehensive analysis of rice DREB2-type genes that encode transcription factors involved in the expression of abiotic stress-responsive genes.
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Kido Y, Sakamoto K, Nakamura K, Harada M, Suzuki T, Yabu Y, Saimoto H, Yamakura F, Ohmori D, Moore A, Harada S, Kita K.
Purification and kinetic characterization of recombinant alternative oxidase from Trypanosoma brucei brucei.
-
Sato T, Honma T, Yokoyama S.
Combining Machine Learning and Pharmacophore-Based Interaction Fingerprint for in Silico Screening.
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Okuno T, Nakatsuji Y, Moriya M, Takamatsu H, Nojima S, Takegahara N, Toyofuku T, Nakagawa Y, Kang S, Friedel RH, Sakoda S, Kikutani H, Kumanogoh A.
Roles of Sema4D-Plexin-B1 Interactions in the Central Nervous System for Pathogenesis of Experimental Autoimmune Encephalomyelitis.
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Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, Kato R.
Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer.
-
Paranagama MP, Sakamoto K, Amino H, Awano M, Miyoshi H, Kita K.
Contribution of the FAD and quinone binding sites to the production of reactive oxygen species from Ascaris suum mitochondrial complex II.
-
Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, Saitoh T, Akira S, Kawai T.
Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan.
-
Sakata S, Kurokawa T, Noerholm MH, Takagi M, Okochi Y, von Heijne G, Okamura Y.
Functionality of the voltage-gated proton channel truncated in S4.
-
Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura SI, Natsume T, Kang SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M.
A novel type of E3-ligase for the Ufm1-conjugation system.
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Ooshio T, Kobayashi R, Ikeda W, Miyata M, Fukumoto Y, Matsuzawa N, Ogita H, Takai Y.
Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in Madin-Darby canine kidney cells.
-
Mizuhara T, Oishi S, Fujii N, Ohno H.
Efficient Synthesis of Pyrimido[1,2-c] [1,3]benzothiazin-6-imines and Related Tricyclic Heterocycles by S(N)Ar-Type C-S, C-N, or C-O Bond Formation with Heterocumulenes.
-
Kamada Y, Yoshino KI, Kondo C, Kawamata T, Oshiro N, Yonezawa K, Ohsumi Y.
Tor directly controls the Atg1 kinase complex to regulate autophagy.
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Shinzawa-Itoh K, Yoshikawa S.
Bovine heart NADH-ubiquinone oxidoreductase contains one molecule of ubiquinone with 10 isoprene units as one of the cofactors.
-
Kimura S, Suzuki T.
Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA.
-
Takeda M, Jee J, Ono AM, Terauchi T, Kainosho M.
Hydrogen Exchange Rate of Tyrosine Hydroxyl Groups in Proteins As Studied by the Deuterium Isotope Effect on C(zeta) Chemical Shifts.
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Yoshida T, Fujita Y, Sayama H, Maruyama K, Mizoi J, Shinozaki K, Yamaguchi-Shinozaki K.
AREB1, AREB2, and ABF3 are master transcription factors that cooperatively regulate ABRE-dependent ABA signaling involved in drought stress tolerance and require ABA for full activation.
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Yasui N, Mihara E, Nampo M, Tamura-Kawakami K, Unno H, Matsumoto K, Takagi J.
Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation.
-
Suzuki T, Miyauchi K.
Discovery and characterization of tRNA(Ile) lysidine synthetase (TilS).
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Yamazaki Y, Akashi R, Banno Y, Endo T, Ezura H, Fukami-Kobayashi K, Inaba K, Isa T, Kamei K, Kasai F, Kobayashi M, Kurata N, Kusaba M, Matuzawa T, Mitani S, Nakamura T, Nakamura Y, Nakatsuji N, Naruse K, Niki H, Nitasaka E, Obata Y, Okamoto H, Okuma M, Sato K, Serikawa T, Shiroishi T, Sugawara H, Urushibara H, Yamamoto M, Yaoita Y, Yoshiki A, Kohara Y.
NBRP databases: databases of biological resources in Japan.
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Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S.
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.
-
Okazaki Y, Eto K, Yamashita T, Okamoto M, Ohsugi M, Noda M, Terauchi Y, Ueki K, Kadowaki T.
Decreased Insulin Secretion and Accumulation of Triglyceride in beta Cells Overexpressing a Dominant-Negative Form of AMP-Activated Protein Kinase.
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Enomoto T, Girard AL, Yasui Y, Takemoto Y.
Gold(I)-Catalyzed Tandem Reactions Initiated by Hydroamination of Alkynyl Carbamates: Application to the Synthesis of Nitidine.
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Nakamura A, Sheppard K, Yamane J, Yao M, Soll D, Tanaka I.
Two distinct regions in Staphylococcus aureus GatCAB guarantee accurate tRNA recognition.
-
Maher MJ, Akimoto S, Iwata M, Nagata K, Hori Y, Yoshida M, Yokoyama S, Iwata S, Yokoyama K.
Crystal structure of A(3)B(3) complex of V-ATPase from Thermus thermophilus.
-
Nemoto W, Fukui K, Toh H.
GRIP: A server for predicting interfaces for GPCR oligomerization.
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Fujioka Y, Noda NN, Nakatogawa H, Ohsumi Y, Inagaki F.
The dimeric coiled-coil structure of Saccharomyces cerevisiae ATG16 and its functional significance in autophagy.
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Miyata M, Ogita H, Komura H, Nakata S, Okamoto R, Ozaki M, Majima T, Matsuzawa N, Kawano S, Minami A, Waseda M, Fujita N, Mizutani K, Rikitake Y, Takai Y.
Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor.
-
Minamino T, Yoshimura SD, Morimoto YV, Gonz?lez-Pedrajo B, Kami-Ike N, Namba K.
Roles of the extreme N-terminal region of FliH for efficient localization of the FliH-FliI complex to the bacterial flagellar type III export apparatus.
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Yamaji K, Kanai T, Nomura SM, Akiyoshi K, Negishi M, Chen Y, Atomi H, Yoshikawa K, Imanaka T.
Protein synthesis in giant liposomes using the in vitro translation system of Thermococcus kodakaraensis.
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Fujita Y, Nakashima K, Yoshida T, Katagiri T, Kidokoro S, Kanamori N, Umezawa T, Fujita M, Maruyama K, Ishiyama K, Kobayashi M, Nakasone S, Yamada K, Ito T, Shinozaki K, Yamaguchi-Shinozaki K.
Three SnRK2 Protein Kinases are the Main Positive Regulators of Abscisic Acid Signaling in Response to Water Stress in Arabidopsis.
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Oda T, Hashimoto H, Kuwabara N, Akashi S, Hayashi K, Kojima C, Wong HL, Kawasaki T, Shimamoto K, Sato M, Shimizu T.
The structure of the N-terminal regulatory domain of a plant NADPH oxidase and its functional implications.
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Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T.
Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.
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Miyazono KI, Miyakawa T, Sawano Y, Kubota K, Kang HJ, Asano A, Miyauchi Y, Takahashi M, Zhi Y, Fujita Y, Yoshida T, Kodaira K, Yamaguchi-Shinozaki K, Tanokura M.
Structural basis of abscisic acid signalling.
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Kobayashi E, Shimizu R, Kikuchi Y, Takahashi S, Yamamoto M.
Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domain.
-
Ogura K, Yamasaki M, Yamada T, Mikami B, Hashimoto W, Murata K.
Crystal structure of family 14 polysaccharide lyase with pH-dependent modes of action.
-
Shindoh N, Takemoto Y, Takasu K.
Auto-Tandem Catalysis: A Single Catalyst Activating Mechanistically Distinct Reactions in a Single Reactor.
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Kodera T, Smirnov SV, Samsonova NN, Kozlov YI, Koyama R, Hibi M, Ogawa J, Yokozeki K, Shimizu S.
A novel L-isoleucine hydroxylating enzyme, L-isoleucine dioxygenase from Bacillus thuringiensis, produces (2S,3R,4S)-4-hydroxyisoleucine.
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Toda E, Terashima Y, Sato T, Hirose K, Kanegasaki S, Matsushima K.
FROUNT Is a Common Regulator of CCR2 and CCR5 Signaling to Control Directional Migration.
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Kofuku Y, Yoshiura C, Ueda T, Terasawa H, Hirai T, Tominaga S, Hirose M, Maeda Y, Takahashi H, Terashima Y, Matsushima K, Shimada I.
Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4.
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Kidokoro S, Maruyama K, Nakashima K, Imura Y, Narusaka Y, Shinwari ZK, Osakabe Y, Fujita Y, Mizoi J, Shinozaki K, Yamaguchi-Shinozaki K.
The Phytochrome-Interacting Factor PIF7 Negatively Regulates DREB1 Expression under Circadian Control in Arabidopsis.
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Selim KB, Matsumoto Y, Yamada KI, Tomioka K.
Efficient Chiral N-Heterocyclic Carbene/Copper(I)-Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents.
-
Hashimoto W, Kawai S, Murata K.
Bacterial supersystem for alginate import/metabolism and its environmental and bioenergy applications.
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Nishio K, Kim SW, Kawai K, Mizushima T, Yamane T, Hamazaki J, Murata S, Tanaka K, Morimoto Y.
Crystal structure of the deubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain.
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Kajiwara K, Watanabe K, Tokiwa R, Kurose T, Ohno H, Tsutsumi H, Hata Y, Izumi K, Kodama E, Matsuoka M, Oishi S, Fujii N.
Bioorganic synthesis of a recombinant HIV-1 fusion inhibitor, SC35EK, with an N-terminal pyroglutamate capping group.
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Arai S, Yamato I, Shiokawa A, Saijo S, Kakinuma Y, Ishizuka-Katsura Y, Toyama M, Terada T, Shirouzu M, Yokoyama S, Iwata S, Murata T.
Reconstitution in vitro of the catalytic portion (NtpA(3)-B(3)-D-G complex) of Enterococcus hirae V-type Na(+)-ATPase.
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Saito K, Inagaki S, Mituyama T, Kawamura Y, Ono Y, Sakota E, Kotani H, Asai K, Siomi H, Siomi MC.
A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila.
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Yura K, Sulaiman S, Hatta Y, Shionyu M, Go M.
RESOPS: A Database for Analyzing the Correspondence of RNA Editing Sites to Protein Three-Dimensional Structures.
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Umezawa T, Sugiyama N, Mizoguchi M, Hayashi S, Myouga F, Yamaguchi-Shinozaki K, Ishihama Y, Hirayama T, Shinozaki K.
Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis.
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Wong HL, Shimamoto K.
Sending ROS on a bullet train.
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Yagi H, Konno H, Murakami-Fuse T, Isu A, Oroguchi T, Akutsu H, Ikeguchi M, Hisabori T.
Structural and functional analysis of the intrinsic inhibitor subunit epsilon of F1-ATPase from photosynthetic organisms.
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Yura K, Hayward S.
The interwinding nature of protein-protein interfaces and its implication for protein complex formation.
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Takeda K, Kusumoto K, Hirano Y, Miki K.
Detailed assessment of X-ray induced structural perturbation in a crystalline state protein.
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Kurokawa H, Motohashi H, Sueno S, Kimura M, Takagawa H, Kanno Y, Yamamoto M, Tanaka T.
Structural Basis of Alternative DNA Recognition by Maf Transcription Factors.
-
Watanabe S, Arai T, Matsumi R, Atomi H, Imanaka T, Miki K.
Crystal structure of HypA, a nickel binding metallochaperone for [NiFe] hydrogenase maturation.
-
Tabata KV, Sato K, Ide T, Nishizaka T, Nakano A, Noji H.
Visualization of cargo concentration by COPII minimal machinery in a planar lipid membrane.
-
Komiya R, Yokoi S, Shimamoto K.
A gene network for long-day flowering activates RFT1 encoding a mobile flowering signal in rice.
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Goto-Ito S, Ito T, Kuratani M, Bessho Y, Yokoyama S.
Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation.
-
Kabeya Y, Noda NN, Fujioka Y, Suzuki K, Inagaki F, Ohsumi Y.
Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
-
Araiso Y, Sherrer RL, Ishitani R, Ho JM, S?ll D, Nureki O.
Structure of a tRNA-dependent kinase essential for selenocysteine decoding.
-
Shimono K, Goto M, Kikukawa T, Miyauchi S, Shirouzu M, Kamo N, Yokoyama S.
Production of functional bacteriorhodopsin by an Escherichia coli cell-free protein synthesis system supplemented with steroid detergent and lipid.
-
Hull JJ, Lee JM, Kajigaya R, Matsumoto S.
Bombyx mori homologs of STIM1 and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.
-
Inuki S, Yoshimitsu Y, Oishi S, Fujii N, Ohno H.
Ring-Construction/Stereoselective Functionalization Cascade: Total Synthesis of Pachastrissamine (Jaspine B) through Palladium-Catalyzed Bis-cyclization of Bromoallenes.
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Hao X, Kuriyama M, Chen Q, Yamamoto Y, Yamada KI, Tomioka K.
Steric Tuning of the Amidomonophosphane-Rhodium(I) Catalyst in Asymmetric Addition of Arylboroxines to N-Phosphinoyl Aldimines.
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Feng C, Araki M, Kunimoto R, Tamon A, Makiguchi H, Niijima S, Tsujimoto G, Okuno Y.
GEM-TREND: a web tool for gene expression data mining toward relevant network discovery.
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Minamino T, Moriya N, Hirano T, Hughes KT, Namba K.
Interaction of FliK with the bacterial flagellar hook is required for efficient export specificity switching.
-
Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Sugimoto H, Utsunomiya H, Oda K, Warabi E, Ishii T, Yamamoto M.
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems.
-
Saio T, Yokochi M, Inagaki F.
The NMR structure of the p62 PB1 domain, a key protein in autophagy and NF-kappaB signaling pathway.
-
Umitsu M, Nishimasu H, Noma A, Suzuki T, Ishitani R, Nureki O.
Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2.
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Takazawa T, Yamauchi T, Tsuchida A, Takata M, Hada Y, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T.
Peroxisome proliferator-activated receptor {gamma} agonist rosiglitazone increases the expression of very low density lipoprotein receptor gene in adipocytes.
-
Itoh Y, Chiba S, Sekine SI, Yokoyama S.
Crystal structure of human selenocysteine tRNA.
-
Yuzawa S, Miyano K, Honbou K, Inagaki F, Sumimoto H.
The domain organization of p67 phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes.
-
Kumar H, Kawai T, Akira S.
Toll-like Receptors and Innate Immunity.
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Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T.
Single chain variable fragment against Nicastrin inhibits the {gamma}-secretase activity.
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He F, Saito K, Kobayashi N, Harada T, Watanabe S, Kigawa T, G?ntert P, Ohara O, Tanaka A, Unzai S, Muto Y, Yokoyama S.
Structural and functional characterization of the NHR1 domain of the Drosophila Neuralized E3 ligase in the Notch signaling pathway.
-
Ohta Y, Chiba H, Oishi S, Fujii N, Ohno H.
Construction of Nitrogen Heterocycles Bearing an Aminomethyl Group by Copper-Catalyzed Domino Three-Component Coupling-Cyclization.
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Kawagoe T, Takeuchi O, Takabatake Y, Kato H, Isaka Y, Tsujimura T, Akira S.
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis.
-
Takeda M, Ono AM, Terauchi T, Kainosho M.
Application of SAIL phenylalanine and tyrosine with alternative isotope-labeling patterns for protein structure determination.
-
Kazetani KI, Minamino T, Miyata T, Kato T, Namba K.
ATP-induced FliI hexamerization facilitates bacterial flagellar protein export.
-
Akanuma G, Hara H, Ohnishi Y, Horinouchi S.
Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA in Streptomyces griseus.
-
Aoki M, Matsuda T, Tomo Y, Miyata Y, Inoue M, Kigawa T, Yokoyama S.
Automated system for high-throughput protein production using the dialysis cell-free method.
-
Shimizu K, Toh H.
Interaction between intrinsically disordered proteins frequently occurs in a human protein-protein interaction network.
-
Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, Goshima Y.
Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.
-
Kiyose K, Aizawa S, Sasaki E, Kojima H, Hanaoka K, Terai T, Urano Y, Nagano T.
Molecular Design Strategies for Near-Infrared Ratiometric Fluorescent Probes Based on the Unique Spectral Properties of Aminocyanines.
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Otani K, Kitayama J, Yasuda K, Nio Y, Iwabu M, Okudaira S, Aoki J, Yamauchi T, Kadowaki T, Nagawa H.
Adiponectin suppresses tumorigenesis in Apc(Min)(/+) mice.
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Yano Y, Matsuzaki K.
Tag-probe labeling methods for live-cell imaging of membrane proteins.
-
Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, Akira S.
Poly I:C-Induced Activation of NK Cells by CD8{alpha}+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways.
-
Hiyama TB, Ito T, Imataka H, Yokoyama S.
Crystal structure of the alpha subunit of human translation initiation factor 2B.
-
Kojima S, Imada K, Sakuma M, Sudo Y, Kojima C, Minamino T, Homma M, Namba K.
Stator assembly and activation mechanism of the flagellar motor by the periplasmic region of MotB.
-
Katsuyama Y, Kita T, Horinouchi S.
Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.
-
Watabe T, Terakawa Y, Watanabe K, Ohno H, Nakano H, Nakatsu T, Kato H, Izumi K, Kodama E, Matsuoka M, Kitaura K, Oishi S, Fujii N.
X-ray Crystallographic Study of an HIV-1 Fusion Inhibitor with the gp41 S138A Substitution.
-
Ikeya T, Takeda M, Yoshida H, Terauchi T, Jee JG, Kainosho M, Güntert P.
Automated NMR structure determination of stereo-array isotope labeled ubiquitin from minimal sets of spectra using the SAIL-FLYA system.
-
Miyata M, Rikitake Y, Takahashi M, Nagamatsu Y, Yamauchi Y, Ogita H, Hirata KI, Takai Y.
Regulation by Afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA Small G proteins at leading edges of moving NIH3T3 cells.
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Nozawa A, Matsubara Y, Tanaka Y, Takahashi H, Akagi T, Seki M, Shinozaki K, Endo Y, Sawasaki T.
Construction of a Protein Library of Arabidopsis Transcription Factors Using a Wheat Cell-Free Protein Production System and Its Application for DNA Binding Analysis.
-
Izumi S, Urano Y, Hanaoka K, Terai T, Nagano T.
A Simple and Effective Strategy To Increase the Sensitivity of Fluorescence Probes in Living Cells.
-
Ohta Y, Kubota Y, Watabe T, Chiba H, Oishi S, Fujii N, Ohno H.
Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four-Component Coupling, Cascade Cyclization, and Oxidation.
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Chen Q, Kuriyama M, Hao X, Soeta T, Yamamoto Y, Yamada K, Tomioka K.
Chiral amidophosphane-rhodium(i)-catalyzed asymmetric conjugate arylation of acyclic enones with arylboronic acids.
-
Miyanaga A, Horinouchi S.
Enzymatic synthesis of bis-5-alkylresorcinols by resorcinol-producing type III polyketide synthases.
-
Tsuda K, Kuwasako K, Takahashi M, Someya T, Inoue M, Terada T, Kobayashi N, Shirouzu M, Kigawa T, Tanaka A, Sugano S, Güntert P, Muto Y, Yokoyama S.
Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3.
-
Uematsu S, Akira S.
Immune responses of TLR5(+) lamina propria dendritic cells in enterobacterial infection.
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Sokabe M, Ose T, Nakamura A, Tokunaga K, Nureki O, Yao M, Tanaka I.
The structure of alanyl-tRNA synthetase with editing domain.
-
Shindoh N, Takemoto Y, Takasu K.
Atropisomerism of alpha,beta-Unsaturated Amidines: Stereoselective Synthesis by Catalytic Cascade Reaction and Optical Resolution.
-
Miyano K, Koga H, Minakami R, Sumimoto H.
The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases.
-
Tanaka Y, Yamagata S, Kitago Y, Yamada Y, Chimnaronk S, Yao M, Tanaka I.
Deduced RNA binding mechanism of ThiI based on structural and binding analyses of a minimal RNA ligand.
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Mogi T, Kawakami T, Arai H, Igarashi Y, Matsushita K, Mori M, Shiomi K, Omura S, Harada S, Kita K.
Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor.
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Oishi S, Kodera Y, Nishikawa H, Kamitani H, Watabe T, Ohno H, Tochikura T, Shimane K, Kodama E, Matsuoka M, Mizukoshi F, Tsujimoto H, Fujii N.
Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus.
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Fujiwara M, Hamada S, Hiratsuka M, Fukao Y, Kawasaki T, Shimamoto K.
Proteome analysis of detergent resistant membranes (DRMs) associated with OsRac1 mediated innate immunity in rice.
-
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y.
Dynamics and diversity in autophagy mechanisms: lessons from yeast.
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Watanabe T, Oishi S, Fujii N, Ohno H.
Palladium-Catalyzed Direct Synthesis of Carbazoles via One-Pot N-Arylation and Oxidative Biaryl Coupling: Synthesis and Mechanistic Study.
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Ando A, Sakuradani E, Horinaka K, Ogawa J, Shimizu S.
Transformation of an oleaginous zygomycete Mortierella alpina 1S-4 with the carboxin resistance gene conferred by mutation of the iron-sulfur subunit of succinate dehydrogenase.
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Tezuka T, Hara H, Ohnishi Y, Horinouchi S.
Identification and Gene Disruption of Small Non-coding RNAs in Streptomyces griseus.
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Nakano C, Ozawa H, Akanuma G, Funa N, Horinouchi S.
Biosynthesis of Aliphatic Polyketides by Type III Polyketide Synthase and Methyltransferase in Bacillus subtilis.
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Apostolov RP, Yonezawa Y, Standley DM, Kikugawa G, Takano Y, Nakamura H.
Membrane attachment facilitates ligand access to active site in Monoamine Oxidase A.
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Aya K, Ueguchi-Tanaka M, Kondo M, Hamada K, Yano K, Nishimura M, Matsuoka M.
Gibberellin Modulates Anther Development in Rice via the Transcriptional Regulation of GAMYB.
-
Ogura K, Tandai T, Yoshinaga S, Kobashigawa Y, Kumeta H, Ito T, Sumimoto H, Inagaki F.
NMR structure of the heterodimer of Bem1 and Cdc24 PB1 domains from Saccharomyces cerevisiae.
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Kobayashi K, Narumi T, Oishi S, Ohno H, Fujii N.
Amino Acid-Based Synthesis of Trifluoromethylalkene Dipeptide Isosteres by Alcohol-Assisted Nucleophilic Trifluoromethylation and Organozinc-Copper-Mediated S(N)2' Alkylation.
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Saeki Y, Toh-E A, Kudo T, Kawamura H, Tanaka K.
Multiple Proteasome-Interacting Proteins Assist the Assembly of the Yeast 19S Regulatory Particle.
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Chimnaronk S, Forouhar F, Sakai J, Yao M, Tron CM, Atta M, Fontecave M, Hunt JF, Tanaka I.
Snapshots of Dynamics in Synthesizing N6-isopentenyladenosine at tRNA Anticodon.
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Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T.
Inhibition of gamma-Secretase Activity by Helical beta-Peptide Foldamers.
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Suzuki Y, Ohta Y, Oishi S, Fujii N, Ohno H.
Efficient Synthesis of Aminomethylated Pyrroloindoles and Dipyrrolopyridines via Controlled Copper-Catalyzed Domino Multicomponent Coupling and Bis-cyclization.
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Fuchikawa T, Nakamura F, Fukuda N, Takei K, Goshima Y.
Protein tyrosine phosphatase SHP2 is involved in Semaphorin 4D-induced axon repulsion.
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Naganuma M, Sekine SI, Fukunaga R, Yokoyama S.
Unique protein architecture of alanyl-tRNA synthetase for aminoacylation, editing, and dimerization.
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Makide K, Kitamura H, Sato Y, Okutani M, Aoki J.
Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol.
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Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N,Kikuchi N, Satoh H, Sakamoto T, Hizawa N, Itoh K, Yamamoto M.
Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugsin Human Lung Cancer.
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Kwon Y, Shigemoto Y, Kuwana Y, Sugawara H.
Web API for biology with a workflow navigation system.
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Nishimasu H, Ishitani R, Yamashita K, Iwashita C, Hirata A, Hori H,Nureki O.
Atomic structure of a folate/FAD-dependent tRNA T54methyltransferase.
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Maruyama Y, Makamichi Y, Itoh T, Mikami B, Hashimoto W, Murata K.
Substrate specificity of streptococccal unsaturated glucuronylhydrolases to sulfated glycosaminoglycan.
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Sakuradani E, Nojiri M, Suzuki H, Shimizu S.
Identification of a novel fatty acid elongase with a wide substratespecificity from arachidonic acid-producing fungus Mortierella alpina1S-4.
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Endo T, Kano K, Motoki R, Hama K, Okudaira S, Ishida M, Ogiso H,Tanaka M, Matsuki N, Taguchi R, Kanai M, Shibasaki M, Arai H, Aoki J.
Lysophosphatidylmethanol is a pan lysophosphatidic acid receptoragonist and is produced by autotaxin in blood.
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Inokuma T, Takasu K, Sakaeda T, Takemoto Y.
Hydroxyl Group-Directed Organocatalytic Asymmetric Michael Additionof alpha,beta-Unsaturated Ketones with Alkenylboronic Acids.
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Takimoto K, Wakiyama M, Yokoyama S.
Mammalian GW182 contains multiple Argonaute-binding sites andfunctions in microRNA-mediated translational repression.
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Takahasi K, Kumeta H, Tsuduki N, Narita R, Shigemoto T, Hirai R,Yoneyama M, Horiuchi M, Ogura K, Fujita T, Inagaki F.
Solution structures of cytosolic RNA sensors MDA5 and LGP2 C-terminaldomains: Identification of the RNA recognition loop in RIG-I likereceptors.
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Koide Y, Urano Y, Yatsushige A, Hanaoka K, Terai T, Nagano T.
Design and Development of Enzymatically Activatable PhotosensitizerBased on Unique Characteristics of Thiazole Orange.
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Sekito T, Kawamata T, Ichikawa R, Suzuki K, Ohsumi Y.
Atg17 recruits Atg9 to organize the pre-autophagosomal structure.
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Fukunishi Y, Mashimo T, Orita M, Ohno K, Nakamura H.
In Silico Fragment Screening by Replica Generation (FSRG) Method forFragment-Based Drug Design.
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Ohta Y, Oishi S, Fujii N, Ohno H.
Facile Synthesis of 1,2,3,4-Tetrahydro-beta-carbolines by One-PotDomino Three-Component Indole Formation and Nucleophilic Cyclization.
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Yamamoto Y, Yasuda Y, Nasu H, Tomioka K.
Asymmetric Construction of Three Contiguous Stereogenic Centers byConjugate Addition-Alkylation of Lithium Ester Enolate.
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Watanabe YH, Nakazaki Y, Suno R, Yoshida M.
Stability of the two wings of the coiled-coil domain of ClpBchaperone is critical for its disaggregation activity.
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Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q,Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y,Sasaki T, Frohman MA, Fukui Y.
Sequential Regulation of DOCK2 Dynamics by Two Phospholipids duringNeutrophil Chemotaxis.
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Chimnaronk S, Suzuki T, Manita T, Ikeuchi Y, Yao M, Suzuki T, TanakaI.
RNA helicase module in an acetyltransferase that modifies a specifictRNA anticodon.
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Satoo K, Noda NN, Kumeta H, Fujioka Y, Mizushima N, Ohsumi Y, InagakiF.
The structure of Atg4B-LC3 complex reveals the mechanism of LC3processing and delipidation during autophagy.
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Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, MiyakeT, Satoh T, Kato H, Tsujimura T, Nakamura H, Akira S.
Zc3h12a is an RNase essential for controlling immune responses byregulating mRNA decay.
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Kishino S, Ogawa J, Yokozeki K, Shimizu S.
Metabolic diversity in biohydrogenation of polyunsaturated fattyacids by lactic acid bacteria involving conjugated fatty acidproduction.
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Sugawara T, Ito K, Shiroishi M, Tokuda N, Asada H, Yurugi-KobayashiT, Shimamura T, Misaka T, Nomura N, Murata T, Abe K, Iwata S, KobayashiT.
Flourescence-based optimization of human bitter taste receptorexpression in Saccharomyces cerevisiae.
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Saitoh A, Shin HW, Yamada A, Waguri S, Nakayama K.
Three homologous ArfGAPs participate in COPI-mediated transport.
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Suzuki Y, Noma A, Suzuki T, Ishitani R, Nureki O.
Structural basis of tRNA modification with CO2 fixation andmethylation by wybutosine synthesizing enzyme TYW4.
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Hara T, Tainosho A, Nakamura K, Sato T, Kawakami T, Aimoto S.
Peptide purification by affinity chromatography based onalpha-ketoacyl group chemistry.
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Hanada T, Satomi Y, Takao T, Ohsumi Y.
The amino-terminal region of Atg3 is essential for association withphosphatidylethanolamine in Atg8 lipidation.
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Okochi Y, Sasaki M, Iwasaki H, Okamura Y.
Voltage-gated proton channel is expressed on phagosomes.
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Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T,Kawamura-Tsuzuku J, Takahasi K, Yamamoto T, Inagaki F.
Structural basis for the antiproliferative activity of the Tob-hCaf1complex.
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Yonezawa Y, Nakata K, Sakakura K, Takada T, Nakamura H.
Intra- and Intermolecular Interaction Inducing Pyramidalization onBoth Sides of a Proline Dipeptide during Isomerization: An Ab InitioQM/MM Molecular Dynamics Simulation Study in Explicit Water.
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Horinouchi S.
Combinatorial biosynthesis of plant medicinal polyketides bymicroorganisms.
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Yamamoto Y, Mochida S, Kurooka T, Sakisaka T.
Reciprocal intramolecular interactions of tomosyn control itsinhibitory activity on the SNARE complex formation.
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Katsuyama Y, Kita T, Funa N, Horinouchi S.
Curcuminoid biosynthesis by two type III polyketide synthases in theherb curcuma longa.
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Tsumuraya M, Furuike S, Adachi K, Kinosita Jr K, Yoshida M.
Effect of epsilon subunit on the rotation of thermophilic BacillusF(1)-ATPase.
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Awazawa M, Ueki K, Inabe K, Yamauchi T, Kaneko K, Okazaki Y, BardeesyN, Ohnishi S, Nagai R, Kadowaki T.
Adiponectin Suppresses Hepatic SREBP1c Expression in anAdipoR1/LKB1/AMPK dependent pathway.
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Niwa T, Ying B-W, Saito K, Jin WZ, Takada S, Ueda T and Taguchi H.
Bimodal protein solubility distribution revealed by an aggregationanalysis of the entire ensemble of Escherichia coli proteins.
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Kawai T, Akira S.
The roles of TLRs, RLRs and NLRs in pathogen recognition.
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Yamada KI, Yamashita M, Sumiyoshi T, Nishimura K, Tomioka K.
Total Synthesis of (-)-Lycorine and (-)-2-epi-Lycorine by AsymmetricConjugate Addition Cascade.
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Takahashi Y, Teshima KM, Yokoi S, Innan H, and Shimamoto K.
Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expressionlevels contribute to diversity of flowering time in cultivated rice.
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Kawai K, Saito A, Sudo T, Osada H.
p38 MAP kinase inhibitor screening method utilizing growth recoveryof Escherichia coli as an index.
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Noda NN, Ohsumi Y, Inagaki F.
ATG Systems from the Protein Structural Point of View.
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Kodan A, Shibata H, Matsumoto T, Terakado K, Sakiyama K, Matsuo M,Ueda K, Kato H.
Improved expression and purification of human multidrug resistanceprotein MDR1 from baculovirus-infected insect cells.
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Osada E, Shimizu Y, Akbar BK, Kanamori T, Ueda T.
Epitope mapping using ribosome display in a reconstituted cell-freeprotein synthesis system.
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Miyazaki I, Simizu S, Ishida K, Osada H.
On-Chip Fragment-Based Approach for Discovery of High-AffinityBivalent Inhibitors.
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Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T,Takahashi S, Sugimoto Y, Osada H.
Identification of Cytochrome P450s Required for FumitremorginBiosynthesis in Aspergillus fumigatus.
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Nishimoto-Morita K, Shin HW, Mitsuhashi H, Kitamura M, Zhang Q,Johannes L, Nakayama K.
Differential effects of depletion of ARL1 and ARFRP1 on membranetrafficking between the trans-Golgi network and endosomes.
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Miyazaki I, Okumura H, Simizu S, Takahashi Y, Kanoh N, Muraoka Y,Nonomura Y, Osada H.
Structure-Affinity Relationship Study of Bleomycins and Shble Proteinby Use of a Chemical Array.
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Harada M, Murakami H, Okawa A, Okimoto N, Hiraoka S, Nakahara T,Akasaka R, Shiraishi YI, Futatsugi N, Mizutani-Koseki Y, Kuroiwa A,Shirouzu M, Yokoyama S, Taiji M, Iseki S, Ornitz DM, Koseki H.
FGF9 monomer-dimer equilibrium regulates extracellular matrixaffinity and tissue diffusion.
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Inaba K, Murakami S, Nakagawa A, Iida H, Kinjo M, Ito K, Suzuki M.
Dynamic nature of disulphide bond formation catalysts revealed bycrystal structures of DsbB.
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Hishiki A, Hashimoto H, Hanafusa T, Kamei K, Ohashi E, Shimizu T,Ohmori H, Sato M.
Structural basis for novel interactions between human translesionsynthesis polymerases and PCNA.
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Takagi S, Simizu S, Osada H.
RECK Negatively Regulates Matrix Metalloproteinase-9 Transcription.
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Kajiro M, Hirota R, Nakajima Y, Kawanowa K, So-Ma K, Ito I, YamaguchiY, Ohie SH, Kobayashi Y, Seino Y, Kawano M, Kawabe YI, Takei H, HayashiSI, Kurosumi M, Murayama A, Kimura K, Yanagisawa J.
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenicpathways.
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Ochiai A, Itoh T, Mikami B, Hashimoto W, Murata K.
Structural determinants responsible for substrate recognition andmode of action in family 11 polysaccharide lyases.
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Umezawa K, Ikebe J, Nomizu M, Nakamura H, Higo J.
Conformational requirement on peptides to exert laminin's activitiesand search for protein segments with the laminin's activities.
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Purwestri YA, Ogaki Y, Tamaki S, Tsuji H, Shimamoto K.
The 14-3-3 protein GF14c acts as a negative regulator of flowering inrice by interacting with the florigen Hd3a.
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Sakurama H, Takita T, Mikami B, Itoh T, Yasukawa K, Inouye K.
Two Crystal Structures of Lysyl-tRNA Synthetase from Bacillusstearothermophilus in Complex with Lysyladenylate-like Compounds:Insights into the Irreversible Formation of the Enzyme-bound Adenylateof L-Lysine Hydroxamate.
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Okabe M, Minamino T, Imada K, Namba K, Kihara M.
Role of the N-terminal domain of FliI ATPase in bacterial flagellarprotein export.
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Satoh T, Harada N, Hosoya T, Tohyama K, Yamamoto M, Itoh K.
Keap1/Nrf2 system regulates neuronal survival as revealed throughstudy of keap1 gene-knockout mice.
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Yurugi-Kobayashi T, Asada H, Shiroishi M, Shimamura T, Funamoto S,Katsuta N, Ito K, Sugawara T, Tokuda N, Tsujimoto H, Murata T, Nomura N,Haga K, Haga T, Iwata S, Kobayashi T.
Comparison of functional non-glycosylated GPCRs expression in Pichiapastoris.
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Aoyama H, Muramoto K, Shinzawa-Itoh K, Hirata K, Yamashita E,Tsukihara T, Ogura T, Yoshikawa S.
A peroxide bridge between Fe and Cu ions in the O2 reduction site offully oxidized cytochrome c oxidase could suppress the proton pump.
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Saeki Y, Kudo T, Sone T, Kikuchi Y, Yokosawa H, Toh-E A, Tanaka K.
Lysine 63-linked polyubiquitin chain may serve as a targeting signalfor the 26S proteasome.
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Furukawa A, Nagata T, Matsugami A, Habu Y, Sugiyama R, Hayashi F,Kobayashi N, Yokoyama S, Takaku H, Katahira M.
Structure, interaction and real-time monitoring of the enzymaticreaction of wild-type APOBEC3G.
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Kobashigawa Y, Kumeta H, Ogura K, Inagaki F.
Attachment of an NMR-invisible solubility enhancement tag using asortase-mediated protein ligation method.
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Tokunaga F, Sakata SI, Saeki Y, Satomi Y, Kirisako T, Kamei K,Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T,Tanaka K, Iwai K.
Involvement of linear polyubiquitylation of NEMO in NF-kappaBactivation.
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Ohto C, Muramatsu M, Obata S, Sakuradani E, Shimizu S.
Prenyl Alcohol Production by Expression of Exogenous IsopentenylDiphosphate Isomerase and Farnesyl Diphosphate Synthase Genes inEscherichia coli.
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Fujimoto M, Arimura SI, Mano S, Kondo M, Saito C, Ueda T, Nakazono M,Nakano A, Nishimura M, Tsutsumi N.
Arabidopsis dynamin-related proteins DRP3A and DRP3B are functionallyredundant in mitochondrial fission but have distinct roles inperoxisomal fission.
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Su JR, Takeda K, Tamura S, Fujiki Y, Miki K.
Crystal structure of the conserved N-terminal domain of theperoxisomal matrix protein import receptor, Pex14p.
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Morales J, Mogi T, Mineki S, Takashima E, Mineki R, Hirawake H,Sakamoto K, Omura S, Kita K.
Novel mitochondrial complex II isolated from trypanosoma cruzi iscomposed of twelve peptides including a heterodimeric Ip subunit.
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Morales J, Mogi T, Mineki S, Takashima E, Mineki R, Hirawake H,Sakamoto K, Omura S, Kita K.
Novel mitochondrial complex II isolated from trypanosoma cruzi iscomposed of twelve peptides including a heterodimeric Ip subunit.
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Nozawa K, O'Donoghue P, Gundllapalli S, Araiso Y, Ishitani R, UmeharaT, Soll D, Nureki O.
Pyrrolysyl-tRNA synthetase-tRNA(Pyl) structure reveals the molecularbasis of orthogonality.
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Nozawa K, O'Donoghue P, Gundllapalli S, Araiso Y, Ishitani R, UmeharaT, Soll D, Nureki O.
Pyrrolysyl-tRNA synthetase-tRNA(Pyl) structure reveals the molecularbasis of orthogonality.
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Suzuki M, Kawamoto Y, Sakai T, Yamamoto Y, Tomioka K.
Asymmetric Construction of Quaternary Carbon Centers by SequentialConjugate Addition of Lithium Amide and in Situ Alkylation: Utility inthe Synthesis of (-)-Aspidospermidine.
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Akindele T, Yamada KI, Tomioka K.
Dimethylzinc-Initiated Radical Reactions.
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Naito T, Izumi K, Kodama E, Sakagami Y, Kajiwara K, Nishikawa H,Watanabe K, Sarafianos SG, Oishi S, Fujii N, Matsuoka M.
SC29EK, a peptide fusion inhibitor with enhanced {alpha}-helicity,inhibits replication of human immunodeficiency virus type 1 mutantsresistant to enfuvirtide.
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Maehara Y, Miyano K, Sumimoto H.
Role for the first SH3 domain of p67(phox) in activation ofsuperoxide-producing NADPH oxidases.
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Tomita K, Popiel HA, Nagai Y, Toda T, Yoshimitsu Y, Ohno H, Oishi S,Fujii N.
Structure-activity relationship study on polyglutamine bindingpeptide QBP1.
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Suzuki M, Moriguchi T, Ohneda K, Yamamoto M.
Differential Contribution of the Gata1 Gene Hematopoietic Enhancer toErythroid Differentiation.
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Enami K, Ichikawa M, Uemura T, Kutsuna N, Hasezawa S, Nakagawa T,Nakano A, Sato MH.
Differential Expression Control and Polarized Distribution of PlasmaMembrane-Resident SYP1 SNAREs in Arabidopsis thaliana.
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Taura M, Miyano K, Minakami R, Kamakura S, Takeya R, Sumimoto H..
A region N-terminal to the tandem SH3 domain of p47phox plays acrucial role in activation of the phagocyte NADPH oxidase
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Ohto C, Muramatsu M, Obata S, Sakuradani E, Shimizu S.
Overexpression of the gene encoding HMG-CoA reductase inSaccharomyces cerevisiae for production of prenyl alcohols
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Okamura Y, Murata Y, Iwasaki H.
Voltage-sensing phosphatases: actions and potentials
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Tonoki A, Kuranaga E, Tomioka T, Hamazaki J, Murata S, Tanaka K,Miura M.
Genetic evidence linking age-dependent attenuation of the 26Sproteasome with aging process
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Wada S, Ishida H, Izumi M, Yoshimoto K, Ohsumi Y, Mae T, Makino A.
Autophagy plays a role in chloroplast degradation during senescencein individually darkened leaves.
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Kobayashi T, Yanagisawa T, Sakamoto K, Yokoyama S.
Recognition of Non-alpha-amino Substrates by Pyrrolysyl-tRNASynthetase.
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Kimoto M, Kawai R, Mitsui T, Yokoyama S, Hirao I.
An unnatural base pair system for efficient PCR amplification andfunctionalization of DNA molecules.
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Mogi T, Ui H, Shiomi K, Omura S, Miyoshi H, Kita K.
Antibiotics LL-Z1272 identified as novel inhibitors discriminatingbacterial and mitochondrial quinol oxidases.
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Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, WatabeT, Terakawa Y,Nishikawa H, Sarafianos SG, Kitaura K, Oishi S, Fujii N,Matsuoka M.
Design of peptide-based inhibitors for HIV-1 strains resistant toT-20.
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Asano K, Hirano K, Ueguchi-Tanaka M, Angeles-Shim RB, Komura T, SatohH, Kitano H, Matsuoka M, Ashikari M.
Isolation and characterization of dominant dwarf mutants, Slr1-d, inrice.
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Kawahara K, Mogi T, Tanaka TQ, Hata M, Miyoshi H, Kita K.
Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of theRodent Malaria Parasite Plasmodium yoelii yoelii.
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Mizui M, Kumanogoh A, Kikutani H.
Immune Semaphorins: Novel Features of Neural Guidance Molecules.
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Mogi T, Matsushita K, Murase Y, Kawahara K, Miyoshi H, Ui H, ShiomiK, Omura S, Kita K.
Identification of new inhibitors for alternative NADH dehydrogenase(NDH-II).
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