Research Projects

Targeted Proteins Research

Field Project ID Project Theme Principal Investigator Affiliation
Invetigations of
Fundanmental
Biological
Phenomena		 FBA1 Structural and functional studies of bacterial type Ⅲ and type Ⅳ protein export systems Katsumi Imada Graduate School of Frontier Biosciences, Osaka
University
FBA2 Structural basis for dynamic formation and mechanistic actions of huge and complicated proteolytic machinery >>More on this project
 Keiji Tanaka The Tokyo Metropolitan Institute of Medical
Science,Tokyo Metropolitan Organization for
Medical Research
FBA3 Structural basis of autophagy related proteins Fuyuhiko Inagaki Graduate School of Pharmaceutical Sciences,
Hokkaido University
FBA4 Structural biology of transcription factors and histone modification factors Yoshifumi Nishimura International Graduate School of Arts and
Sciences, Yokohama City University
FBA5 Structure and function of voltage-sensor domain proteins Yasushi Okamura Graduate School of Medicine, Osaka University
FBA5 Structure and function of voltage-sensor domain proteins Yasushi Okamura Graduate School of Medicine, Osaka University
FBA7 Structural studies of the cell-cell junctional proteins Toshiaki Sakisaka Graduate School of Medicine, Kobe University
FBB1 Structural Basis of Sensor System for Cytoprotective Gene Expression Responding to Carcinogens and Oxidative Stress Masayuki Yamamoto Graduate School of Medicine, Tohoku University
FBB2 Solid-state NMR investigation on functional and irregular structures of H+-ATPsynthase Fo(2007-2009)
Investigation on the structure and function of ATP-generating membrane protein systems (2010-)		 Hideo Akutsu Institute for Protein Research, Osaka University
FBB3 3D structural and functional analyses for elucidation of the mechanism of mitochondrial respiration (2007-2009) Shinya Yoshikawa Graduate School of Life Science, University of
Hyogo
FBB4 Towards structure-based design of novel inhibitors for V -ATPase(2007-2009)
Membrane transporters: structure and function of important drug targets (2010-) 		So Iwata Graduate School of Medicine, Kyoto University
FBB5 Elucidation of the mechanism of high-order cellular functions achieved by non-coding RNAs Osamu Nurek Institute of Medical Science, The University of
Tokyo
Contribution to
Medical
and
Pharmaceutical
Sciences		 MPA1 Structural analysis of molecules related to the innate immune system Shizuo Akira (2007-2009)
Ken Ishii (2010-)		 Immunology Frontier Research Center, Osaka
University
MPA2 Drug discovery-oriented analysis for structure and function of DOCK2 signaling molecules Yoshinori Fukui Medical Institute of Bioregulation, Kyushu
University
MPA3 Study on reactive oxygen-producing systems involved in neural cell death and structure-based discovery of their inhibitors Hideki Sumimoto Medical Institute of Bioregulation, Kyushu
University
MPA4 Structural analysis of γ-secretase complex for the development of the treatment for Alzheimer's disease Taisuke Tomita Graduate School of Pharmaceutical Sciences,
The University of Tokyo
MPA5 Development of anti-trypanosome drugs targeting nucleic acids and red-ox regulatory pathway >>More on this project Kiyoshi Kita Graduate School of Medical Science, The
University of Tokyo
MPA6 Structure-based functional analyses and development of drug intervention in metabolic syndrome and diabetes- AdipoR/AMPK/ACC as key targets Takashi Kadowaki Graduate School of Medical Science, The
University of Tokyo
MPB1 Structural and Functional Analysis of a Molecular Target FROUNT for Drug Discovery Kouji Matsushima Graduate School of Medical Science, The
University of Tokyo
MPB2 Development of new compounds for fibrosis therapy Junn Yanagisawa Graduate School of Life and Environmental
Sciences, University of Tsukuba
MPB3 Structure and drug development of NPP family members involved in cancer and various diseases Junken Aoki Graduate Schoo of Pharmaceutical Sciences,
Tohoku University
MPB4 Structural and functional analysis of semaphorins and their receptors. Atsushi Kumanogoh Research Institute for Microbial Diseases, Osaka
University
Industrial
Applications
including
Food and
Environment		 FEA1 Structural and functional analyses of signaling proteins for insect control Koji Nagata Graduate School of Agricultural and Life Sciences, The University of Tokyo
FEA2 Structure-based functional analysis of key enzymes that can be applied to production of antibiotics and other useful compounds Yasuo Ohnishi Graduate School of Agricultural and Life Sciences, The University of Tokyo
FEA3 Structural and functional analyses of transcriptional regulatory proteins useful for breading of drought and heat stress tolerant crops Masaru Tanokura Graduate School of Agricultural and Life Sciences ,The University of Tokyo
FEA4 Structural and functional analyses of regulatory proteins in plant growth and stress resistance, that is useful for improvement of the stress-resistant crop Makoto Matsuoka Bioscience and Biotechnology Center, Nagoya
University
FEA5 Structural biology on efflux transport machineries to understand multi-drug resistance >>More on this project Satoshi Murakami Graduate School of Bioscience and
Biotechnology, Tokyo Institute of Technology
FEB1 Structural and functional analyses of the rodent ESP family Hiroaki Terasawa Faculty of Medical and Pharmaceutical Sciences,
Kumamoto University
FEB2 Structural and functional analysis of taste receptors applicable to development of new taste substances and taste evaluation systems (2007-2009) Atsuko Yamashita Structural Physiology Research Group, Harima
Institute, RIKEN
FEB3 Structural biology of bacterial super-biosystem for import and degradation of polysaccharides and its application to food and environmental areas Wataru Hashimoto Graduate School of Agriculture, Kyoto University
FEB4 Structure-function analyses and improvement of useful enzymes for chiral compound prodcution Sakayu Shimizu Graduate School of Agriculture, Kyoto University
FEB6 Structure and function of environmentally-responsive proteins Ko Shimamoto Graduate School of Biological Sciences, Nara
Institute of Science and Technology

Technology Developments

Field Project ID Project Theme Principal Investigator Affiliation
Protein
Production
Technology		 PPC1 Development of Advanced Production Technologies for Target Proteins >>More on this project Shigeyuki Yokoyama Systems and Structural Biology Center, Yokohama Institute, RIKEN
PPD1 Development of novel affinity tag system for the high-quality production of extracellular and membrane proteins (2007-2009) >>More on this project Junichi Takagi Institute for Protein Research, Osaka University
PPD2 Development of innovative methods to support membrane protein crystallization (2007-2009) Hiroaki Kato Graduate School of Pharmaceutical Sciences,
Kyoto University
PPD3 Antibody production for Membrane Protein Crystallisation (2007-2009) So Iwata Graduate School of Medicine, Kyoto University
Protein
Structural
Analysis
Technology		 SAC1 Development of the synchrotron beamlines dedicated to the measurement of micron-size protein crystals >>More on this project Soichi Wakatsuki Institute of Materials Structure Science, High
Energy Accelerator Research Organization(KEK)
SAD1 Structural Analysis of Membrane Protein Complexes by Solid-State NMR (2007-2009) Toshimichi Fujiwara Institute for Protein Research, Osaka University
SAD2 Diversification of protein structural analysis technologies by the SAIL method (2007-2009) Masatsune Kainosho Graduate School of Science, Nagoya University
Chemical
Regulation
Technology		 CRC1 Establishment of Chemical Library and Development of Protein Regulation Technology >>More on this project Tetsuo Nagano Graduate School of Pharmaceutical Sciences,
The University of Tokyo
Informatin
Platform		 IPC1 Creation and management of information platform in Targeted Proteins Research Program >>More on this project Hideaki Sugawara National Institute of Genetics, Research
Organization of Information and Systems
IPD1 Structural Bioinformatics for Modeling Protein Complex Structures (2007-2009) >>More on this project Kei Yura Graduate School of Humanities and Sciences,
Ochanomizu University