Targeted Proteins Research Program

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TP Structure Gallery

TP Structure Gallery

This list is Three-dimensional structures of the TPRP proteins.
The up-to-date list of the TPRP proteins is downloadable here as well.

All proteins

[FBA1] Structural and functional studies of bacterial type [3] and type [4] protein export systems

3A5I
FlhA

3A7M
FliT

3ADY
DotD

3AJW
FliJ

[FBA2] Structural basis for dynamic formation and mechanistic actions of huge and complicated proteolytic machinery

2RRU p62 UBA domain	2Z5B Dmp1-Dmp2	2Z5C Dmp1-Dmp2-[alpha]5 subunit	2Z5E PAC3
2ZJD LC3-p62 complex (human)	3A33 UbcH5b~Ubiquitin conjugate	3A7S UCH37	3ACP Rpn14
3ALB ubiquitin	3AUL ubiquitin	3B0F p62 UBA domain

[FBA3] Structural basis of Atg proteins essential for autophagy

2K6Q LC3-p62(peptide) complex	2KKC p62 PB1 domain	2KTR p62 PB1 domain	2KWC Atg8
2KZB Atg19	2KZK Atg34	2LDR Cbl-b	2LI5 Atg7-Atg8 complex
2ZPN Atg8-Atg19(peptide) complex	2ZZP hAtg4B-LC3 complex	3A7O Atg16	3A7P Atg16
3VGO Cbl-b	3VH1 Atg7	3VH2 Atg7	3VH3 Atg7-Atg8 complex
3VH4 Atg7-Atg8 complex

[FBA4] Structural biology of transcription factors and histone modification factors

2RNQ TFIIEα acidic domain	2RNR TFIIEα acidic domain -p62 PH domain complex	2RNZ Esa1 chromodomain	2RO0 Esa1 knotted tudor domain
2ZFU Nucleomethylin	3APM PAD4	3APN PAD4

[FBA5] Structure and function of voltage-sensor domain proteins

3AWE
Ci-VSP

3AWF
Ci-VSP

3AWG
Ci-VSP

[FBA6] Structure-function analysis of protein complexes that regulate vesicular traffic

2EFC Ara7-AtVps9a complex	2EFD Ara7-AtVps9a complex	2EFE Ara7-AtVps9a complex	2EFH Ara7-AtVps9a complex
2ZVN NEMO cozi domain	2ZVO NEMO cozi domain	3AJ4 Evectin-2	3AXC linear diubiquitin
3F89 NEMO cozi domain	3H3Q CERT START domain	3H3R CERT START domain	3H3S CERT START domain
3H3T CERT START domain	3VIA Evectin-2

[FBA7] Structural studies of the cell-cell junctional proteins

2RRM
ZO-1

3ALP
nectin-1

[FBA8] Mechanism underlying selective activation of NF-kB via linear polyubiquitination

3B08
HOIL-1L

3B0A
HOIL-1L

[FBB1] Structural Basis of Sensor System for Cytoprotective Gene Expression Responding to Carcinogens and Oxidative Stress

3A5T
MafG dimer-DNA complex

3ADE
Keap1-DC

[FBB2] Solid-state NMR investigation on functional and irregular structures of H+-ATPsynthase Fo

2RQ6
F1-ATPase epsilon subunit

2RQ7
F1-ATPase epsilon subunit

[FBB3] 3D structural and functional analyses for elucidation of the mechanism of mitochondrial respiration.

2Z97 Cytochrome P450cam	2ZAW Cytochrome P450cam	2ZAX Cytochrome P450cam	2ZUH Cytochrome P450cam
2ZUI Cytochrome P450cam	2ZUJ Cytochrome P450cam	2ZWT Cytochrome P450cam	2ZWU Cytochrome P450cam
2ZXW Cytochrome c oxidase	3ABL Cytochrome c oxidase	3ABM Cytochrome c oxidase	3AG1 Cytochrome c oxidase
3AG2 Cytochrome c oxidase	3AG3 Cytochrome c oxidase	3AG4 Cytochrome c oxidase	3ASN Cytochrome c oxidase
3ASO Cytochrome c oxidase

[FBB4] Towards structure-based design of novel inhibitors for V-ATPase

2VPW PsrABC	2VPX PsrABC	2VPY PsrABC	2VPZ PsrABC
3AON NtpD-NtpG complex	3AOU NtpK	3GQB A3B3 complex	3RZE histamine H1 receptor
3VG9 adenosine A2A receptor	3VGA adenosine A2A receptor	3ZUX ASBT	3ZUY ASBT

[FBB5] Elucidation of the mechanism of high-order cellular functions achieved by non-coding RNAs

2RRN SecDF	2YYE AaSPS	2Z2U TYW1	2Z67 SepSecS
2ZIO PylRS	2ZJS SecYE	2ZM5 MiaA-tRNA	2ZNI PylRS-tRNA
2ZNJ PylRS	2ZOD AaSPS	2ZPA TmcA	2ZQP SecYE
2ZTG AfuAlaRS N-domain	2ZUL RsmC	2ZVF AfuAlaRS-C-domain	2ZW9 TYW4
2ZWA TYW4	2ZWV RsmC	2ZXH gidA	2ZXI gidA
2ZXU MiaA-tRNA	2ZY6 TPHE39A	2ZZE AlaRS	2ZZF AlaRS
2ZZG AlaRS	2ZZK TYW4	2ZZM MjTRM5-tRNA(Cys)	2ZZN MjTRM5-tRNA(Leu)
3A1P RimM-S19 complex	3A1Y 50S ribosomal protein P1 (L12P) - Acidic ribosomal protein P0 complex	3A25 TYW2(PH0793)	3A26 TYW2(PH0793)
3A27 TYW2(MJ1557)	3A2K TilS	3A3A Selenocysteine-tRNA	3A4L MjPSTK
3A4M MjPSTK	3A4N MjPSTK	3A4T Trm4	3A5Y GenX
3A5Z GenX - EF-P complex	3ADB O-phosphoseryl-tRNA kinase	3ADC O-phosphoseryl-tRNA kinase	3ADD O-phosphoseryl-tRNA kinase
3AFH Glutamyl-tRNA synthetase	3AGJ Pelota-EF1α complex	3AGK aRF1	3AII glutamyl-tRNA synthetase
3AJD Trm4	3AJE Sua5	3AKZ glutamyl-tRNA synthetase	3AL0 glutamine transamidosome
3AL5 TYW5	3AL6 TYW5	3AM1 MjPSTK	3AQO SecDF
3AQP SecDF	3AWI MnmC	3AXS Trm1	3AXT Trm1
3AXZ TrmD	3AY0 Trm5	3B0P Dus	3B0U Dus
3B0V Dus	3G5Q trmFO	3G5R trmFO	3G5S trmFO
3HJ7 TilS	3IP4 GatCAB	3LLH TRBP	3OQH cyclodipeptide synthase
3OQI cyclodipeptide synthase	3OQJ cyclodipeptide synthase	3S7T cyclodipeptide synthase	3UG9 ChR

[MPA2] Drug discovery-oriented analysis for structure and function of DOCK2 signaling molecules

2RQR
DOCK2 - ELMO1 chimera protein

3A98
DOCK2 - ELMO1 complex

[MPA3] Study on reactive oxygen-producing systems involved in neural cell death and structure-based discovery of their inhibitors

2KFJ Cdc24 PB1 domain mutant	2KFK Bem1, Cdc24 PB1 domain complex	2RQV Bem1p SH3CI domain	2RQW Bem1p SH3CI domain
2ZAG STT3(AglB) soluble domain	2ZAI STT3(AglB) soluble domain	3A1F gp91(phox)	3AAG PglB
3AWR Tom20-pALDH complex	3AX2 Tom20-pALDH complex	3AX3 Tom20-pALDH complex	3AX5 Tom20-pALDH complex
3SF4 mInsc-LGN complex

[MPA5] Development of anti-trypanosome drugs targeting nucleic acids and red-ox regulatory pathway

2DJL T.cruzi DHOD	2DJX T.cruzi DHOD	2E68 T.cruzi DHOD	2E6A T.cruzi DHOD
2E6D T.cruzi DHOD	2E6F T.cruzi DHOD	3ABV SQR	3AE1 SQR
3AE2 SQR	3AE3 SQR	3AE4 SQR	3AE5 SQR
3AE6 SQR	3AE7 SQR	3AE8 SQR	3AE9 SQR
3AEA SQR	3AEB SQR	3AEC SQR	3AED SQR
3AEE SQR	3AEF SQR	3AEG SQR

[MPA6] Structure-based functional analyses and development of drug intervention in metabolic syndrome and diabetes- AdipoR/AMPK/ACC as key targets

2ZV2
CaMKK2

3AQV
AMPK alpha 2

[MPB2] Development of new compounds for fibrosis therapy

2ZFU Nucleomethylin	2ZNO PPAR gamma	3AN3 PPAR gamma	3AN4 PPAR gamma
3B0Q PPAR gamma	3B0R PPAR gamma	3B0T VDR

[MPB3] Structure and drug development of NPP family members involved in cancer and various diseases

3NKM autotaxin	3NKN autotaxin	3NKO autotaxin	3NKP autotaxin
3NKQ autotaxin	3NKR autotaxin

[MPB4] Structural and functional analysis of semaphorins and their receptors.

3AFC
Sema6A

3AL8
Sema6A-PlxnA2 complex

3AL9
PlxnA2

[FEA2] Structure-based functional analysis of key enzymes that can be applied to production of antibiotics and other useful compounds

3OIT CUS	3OV2 CURS	3OV3 CURS	3VGK glucokinase
3VGL glucokinase	3VGM glucokinase

[FEA3] Structural and functional analyses of transcriptional regulatory proteins useful for breading of drought and heat stress tolerant crops

3JRQ
PYL1-ABI1

3JRS
PYL1

[FEA4] Structural and functional analyses of regulatory proteins in plant growth and stress resistance, that is useful for improvement of the stress-resistant crop

3EBL
GID1

3ED1
GID1

[FEA6] Study on chemical biology of the deacetylase SIRT3 involved in the regulation of an energy metabolism

3AQA
BRD2-BD1

[FEB3] Structural biology of bacterial super-biosystem for import and degradation of polysaccharides and its application to food and environmental areas

2OKX RhaB	2RGK e.coli YihS	2Z42 alginate lyase A1-II'	2Z8R YesW
2Z8S YesW	2ZA9 alginate lyase A1-II'	2ZAA alginate lyase A1-II'	2ZAB alginate lyase A1-II'
2ZAC alginate lyase A1-II'	2ZBI alginic acid receptor ΔN53C45	2ZBL Salmonella YihS	2ZUX YesW
2ZUY YesX	2ZYC PGH	2ZZR UGL	3A09 AlgQ1
3A0N alginate lyase vAL-1	3A0O Atu3025	3AFL Atu3025	3AFM A1-R
3AFN A1-R	3AMI M16B metallopeptidase	3AMJ M16B metallopeptidase	3ANI UGL
3ANJ UGL	3ANK UGL	3AT7 Algp7	3EVH alginate lyase A1-III
3EVL alginate lyase A1-III	3EW4 alginate lyase A1-III	3GNE alginate lyase vAL-1	3IM0 alginate lyase vAL-1
3K3T PGH	3K8V Flagellin homolog	3K8W Flagellin homolog	3VLU AlgQ1
3VLV AlgQ1	3VLW AlgQ1

[FEB4] Structural and Functional Analyses of Enzymes involved in a New Carbon Dioxide Fixation System and Their Functional Improvement

3A11 R15P isomerase	3A12 Type III Rubisco	3A13 Type III Rubisco SP4 mutant	3A9C R15P isomerase
3KDN Type III Rubisco SP4 mutant	3KDO Type III Rubisco SP6 mutant

[FEB5] Structure-function analyses and improvement of useful enzymes for chiral compound prodcution

3AK4
quinuclidinone reductase

[FEB6] Structure and function of environmentally-responsive proteins

2ZFD
CBL2-CIPK14 complex

3A8R
OsRbohB (NADPH oxidase)

3AXY
Hd3a

[PPC1] Development of Advanced Production Technologies for Target Proteins

2ZIO PylRS	2ZTG AfuAlaRS N-domain	2ZUL RsmC	2ZVF AfuAlaRS-C-domain
2ZWV RsmC	2ZZM MjTRM5-tRNA(Cys)	2ZZN MjTRM5-tRNA(Leu)	3A1P RimM-S19 complex
3A3A Selenocysteine-tRNA	3A4T Trm4	3A5Z GenX - EF-P complex	3ADB O-phosphoseryl-tRNA kinase
3ADC O-phosphoseryl-tRNA kinase	3ADD O-phosphoseryl-tRNA kinase	3AFH Glutamyl-tRNA synthetase	3AJD Trm4
3AJE Sua5	3AKZ glutamyl-tRNA synthetase	3AL0 glutamine transamidosome	3AWI MnmC
3AXS Trm1	3AXT Trm1	3AXZ TrmD	3AY0 Trm5
3LLH TRBP	3AQA BRD2-BD1	2RQR DOCK2 - ELMO1 chimera protein	3A98 DOCK2 - ELMO1 complex
2ZV2 CaMKK2	3AQV AMPK alpha 2	2KSW oryctin	2LDS LaIT1
2ZTS PH0186	3A01 Aristaless and Clawless homeodomains bound to DNA	3A02 Aristaless homeodomain	3A03 Hox11L1 homeodomain
3A4I GMP synthetase	3A76 LinA	3A8Y BAG5 BD5-Hsp70 NBD complex	3A99 Pim-1
3AB3 p115RhoGEF RGS domain - Galpha13 complex	3ABH pacsin2/Syndapin II	3ABT LSD1	3ABU LSD1
3ACO pacsin2/Syndapin II	3ADF Azami-Green	3AEV a/eIF2alpha-aDim2p-rRNA complex	3AI1 L-sorbose reductase
3AI2 L-sorbose reductase	3AI3 L-sorbose reductase	3AJI gankyrin - S6C crosslinked complex	3AM6 AR2
3AOH RNA polymerase - Gfh1 complex	3AOI RNA polymerase - Gfh1 complex	3AQE RAMP2	3AQF CRLR/RAMP2 complex
3ATU Hsp70	3ATV Hsp70	3AU3 APC	3AVR UTX/KDM6A
3AVS UTX/KDM6A	3AY9 Hsp70	3AYH Pol III	3ECS EIF2B1
3GH4 Hex1	3GH5 Hex1	3GH7 Hex1	3LNQ Aristaless homeodomain in complex with DNA
3LQB ZHE1	3MGF MKO	3ORY FEN1	3QHE APC

[PPD1] Development of novel affinity tag system for the high-quality production of extracellular and membrane proteins.

3NKM autotaxin	3NKN autotaxin	3NKO autotaxin	3NKP autotaxin
3NKQ autotaxin	3NKR autotaxin	3AFC Sema6A	3AL8 Sema6A-PlxnA2 complex
3AL9 PlxnA2	2ZOT F-spondin	2ZOU F-spondin	2ZPK p20.1 Fab-peptide complex

[PPD2] Development of innovative methods to support membrane protein crystallization

3AJB
Pex3p

[PPD3] Antibody production for Membrane Protein Crystallisation

3VG9 adenosine A2A receptor	3VGA adenosine A2A receptor	2WDQ succinate:quinone oxidoreductase	2WDR succinate:quinone oxidoreductase
2WDV succinate:quinone oxidoreductase