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Just Epubed section is displaying the most recent 3 Epubs from TPRP.

ABA signaling in stress-response and seed development.

Nakashima K, Yamaguchi-Shinozaki K.

Plant Cell Rep. 2013 Mar 28.

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.

Tanaka Y, Hipolito CJ, Maturana AD, Ito K, Kuroda T, Higuchi T, Katoh T, Kato HE, Hattori M, Kumazaki K, Tsukazaki T, Ishitani R, Suga H, Nureki O.

Nature. 2013 Mar 27.

Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors.

Hou Z, Oishi S, Suzuki Y, Kure T, Nakanishi I, Hirasawa A, Tsujimoto G, Ohno H, Fujii N.

Org Biomol Chem. 2013 Mar 27.

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Gut Bacteria’s Role in Weight

The bacterial makeup of the intestines may help determine whether people gain weight or lose it, according to two new studies, one in humans and one in mice (Sci. Transl. Med. & J. Clin. Endocrinol. Metab.)

March 27, 2013,New York Times,© 2013 The New York Times

Structure of a transporter that creates antibiotic resistance

Researchers determined the structure of MATE (multidrug and toxic compound extrusion) transporter in two conformations and in complexes with several inhibitors, and identified an inhibitory peptide that can thwart the activity of the transporter (Nature)

March 27, 2013,Nature News,© 2013 NPG

Taking the crystals out of X-ray crystallography

Tiny molecular sponges can hold small molecules in position for imaging (Nature)

March 28, 2013,Nature News,© 2013 NPG

Archaea Eat Protein to Survive in Marine Sediments

Researchers pulled out four individual cells of archaea and sequenced their genomic DNA to discover the presence of the extracellular protein-degrading enzymes predicted in those genomes and found these enzymes to be abundant and active in marine sediments (Nature)

March 27, 2013,Science Daily,© 2013 ScienceDaily

First Structures of Serotonin Receptors (5-HT) Family

Researchers reported new crystal structures of 5-HT1B and of 5-HT2B, each bound to the migraine drugs ergotamine and dihydroergotamine (2 papers in Science)

March 22, 2013,Chemical & Engineering News ,© 2013 ACS