Targeted Proteins Research Program

Recent structures (last update : 2012/02/01). Click each image to display the summary information,
and click ID code to access PDB (Protein Data Bank) Database.

[3VG9]
adenosine A2A receptor

[3VGA]
adenosine A2A receptor

[3VLW]
AlgQ1

[3VLV]
AlgQ1

[3VIA]
Evectin-2

Three-dimensional structures of the TPRP proteins are retrievable here.
The up-to-date list of the TPRP proteins is downloadable here as well (Excel format).
Structure Gallery for the Protein 3000 Project (2002-2006, the predecessor of the Targeted Proteins Research Program (TPRP)) is found here.

GPCR Inactivation by an Allosteric Inverse-Agonist Antibody （Kyoto U. / So Iwata） [January 30, 2012]
Structure of the Channelrhodopsin Light-gated Catio Channel （U. Tokyo / Osamu Nureki） [January 23, 2012]
Membrane-trafficking SYP4 proteins regulate disease resistance in plants （U. Tokyo / Akihiko Nakano） [January 17, 2012]
Structure of Cancer and Atoimmune Disease-Related Protein Cbl-b （Hokkaido U. / Fuyuhiko Inagaki） [January 5, 2012]

New addition to the Protein 3000 Structure Gallery
Now, the number of structures in the Protein 3000 Structure Gallery is 3783 with the addition of 106 structural data produced from the Protein 3000 Project and recently registered in the PDB.

Two new bioinformatics tools are now available
TP Atlas (Targeted Proteins Research achievements database) and PCI DB (Protein-Compound Interaction database)

Just Epubed section is displaying the most recent 3 Epubs from TPRP.

G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody.

Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Weyand S, Shimamura T, Nomura N, Cameron AD, Kobayashi T, Hamakubo T, Iwata S, Murata T.

Nature. 2012 Jan 29.

Systems biology and systems chemistry: new directions for drug discovery.

Brown JB, Okuno Y.

Chem Biol. 2012 Jan 27.

Global analysis of DNA methylation in early-stage liver fibrosis.

Komatsu Y, Waku T, Iwasaki N, Ono W, Yamaguchi C, Yanagisawa J.

BMC Med Genomics. 2012 Jan 27.

Resolving Confusion about Resveratrol

Researchers showed that the red wine compound resveratrol increases levels of cyclic AMP, one of the first molecule produced when cells are low on energy, by blocking phosphodiesterase enzymes that break down cyclic AMP (Cell)

Japan plans to merge major science bodies

Drive to save money could increase bureaucracy

Faulty Protein Is Like a Virus in Alzheimer’s

Alzheimer’s disease seems to spread like an infection from brain cell to brain cell, two new studies have found in genetically engineered mice that expressed abnormal human tau, but only in their entorhinal cortexes. But instead of viruses or bacteria, what is being spread is a distorted protein known as tau (PLoS One and Neuron)

Massage’s Mystery Mechanism Unmasked

The massaged legs had 30% more PGC-1alpha, a gene that helps muscle cells build mitochondria, the "engines" that turn a cell's food into energy. They also had three times less NFkB, which turns on genes associated with inflammation (Sci. Transl. Med.)

The low-level nuclear threat

Europe is making a good start on learning about the health risks of low-dose radiation with a program MELODI to share cold-war data and set research priorities. But the effort needs to be global