Targeted Proteins Research Program

Nobel prize laureate, Dr. Ada E.Yonath, presented the plenary lecturer at March 5 Symposium on TPRP
Dr. Ada E.Yonath of Weizmann Institute of Science, a recipient of Nobel Prize in Chemistry last year, gave the plenary lecturer at the Symposium on TPRP on March 5th, 2010. Click the image to view its enlarged version.

Abscisic acid receptors research as a runners-up of “Breakthrough of 2009”
Science magazine selected the research advances in abscisic acid receptors, in which Professors Tanokura, Shinozaki and their colleagues of TPRP played a crucial role (see TP Press Release on Research section below), as a runners-up at its “Breakthrough of the Year” section. Click the image to view its enlarged version.

Recent structures (last update : 2010/03/10). Click each image to display the summary information, and click ID code to access PDB (Protein Data Bank) Database.

[3A5I]
FlhA

[3H3Q]
CERT START domain

[3H3R]
CERT START domain

[3H3S]
CERT START domain

[3H3T]
CERT START domain

Three-dimensional structures of the TPRP proteins are retrievable here.
The up-to-date list of the TPRP proteins is downloadable here as well (Excel format).
Structure Gallery for the Protein 3000 Project (2002-2006, the predecessor of the Targeted Proteins Research Program (TPRP)) is found here.

Novel regulation of Nrf2-Keap1 oxidative stress defense by p62 protein
（Tokyo Metropolitan Institute of Medical Science/ Keiji Tanaka and Tohoku Univ./ Masayuki Yamamoto）[February 22, 2010]
Cherry-bob structure of oxidative stress sensing protein Keap1
(Tohoku Univ. / Masayuki Yamamoto)
[January 19, 2010]
Successful generation of micro-focused beam with 1μm width at SPring-8
(RIKEN / Masaki Yamamoto)
[November 27, 2009]
How plants catch phytohormone abscisic acid
(Tokyo Univ. / Masaru Tanokura)
[October 23, 2009]

Just Epubed section is displaying the most recent 3 Epubs from TPRP.
Official list of papers contributed from TPRP is found here.

Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli.

Katsuyama Y, Hirose Y, Funa N, Ohnishi Y, Horinouchi S.

Biosci Biotechnol Biochem. 2010 Mar 7. [Epub ahead of print]

Estrogen inhibits TGF-beta signaling by promoting Smad2/3 degradation.

Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J.

J Biol Chem. 2010 Mar 5. [Epub ahead of print]

Analysis of the Rac/Rop Small GTPase Family in Rice: Expression, Subcellular Localization and Role in Disease Resistance.

Chen L, Shiotani K, Togashi T, Miki D, Aoyama M, Wong HL, Kawasaki T, Shimamoto K.

Plant Cell Physiol. 2010 Mar 4. [Epub ahead of print]

Study Provides Better Understanding of How Mosquitoes Find a Host

The potentially deadly yellow-fever-transmitting mosquito detects the specific chemical structure of a compound called octenol as one way to find a mammalian host for a blood meal (PLoS ONE)

A Novel Neurotoxin from King Cobra

Snake venoms contain a rich mixture of pharmacologically active peptides and proteins. Researchers have added another member to this class of valuable peptides, providing a detailed structural and functional characterization of a novel neurotoxin from the venom of the king cobra (JBC)

March 9, 2010,JBC Papers of the Week,

Asexual Plant Reproduction May Seed New Approach for Agriculture

Researchers report that they have moved a step closer to turning sexually-reproducing plants into asexual reproducers by highlighting the role of Argonaute 9 in plant reproduction, a finding would eventually allow agricultural companies and farmers to simplify the labor-intensive cross-hybridization methods (Nature)

Potential for Using Algae to Produce Human Therapeutic Proteins Shown

Scientists picked seven proteins that were either currently being used as standard treatments for diseases or are now undergoing human clinical trials and found that the four algal-produced proteins showed biological activity comparable to the same proteins produced by traditional commercial techniques (Plant Biotechnology Journal)

New Ways to Disarm Deadly New World Hemorrhagic Fever Viruses

New World hemorrhagic fever viruses are rodent transmitted agents that cause severe disease. The structure of Machupo virus glycoprotein 1 subunit in complex with human transferrin receptor 1 is described (Nat Struct Mol Biol.)