Targeted Proteins Research Program

Nature News report that, referring to Targeted Proteins Research Program, Phase III of Protein Structural Initiative in USA puts emphasis on troublesome and medically relevant proteins in the name of PSI:Biology.

Nobel prize laureate, Dr. Ada E.Yonath, presented the plenary lecturer at March 5 Symposium on TPRP
Dr. Ada E.Yonath of Weizmann Institute of Science, a recipient of Nobel Prize in Chemistry last year, gave the plenary lecturer at the Symposium on TPRP on March 5th, 2010. Click the image to view its enlarged version.

Abscisic acid receptors research as a runners-up of “Breakthrough of 2009”
Science magazine selected the research advances in abscisic acid receptors, in which Professors Tanokura, Shinozaki and their colleagues of TPRP played a crucial role (see TP Press Release on Research section below), as a runners-up at its “Breakthrough of the Year” section. Click the image to view its enlarged version.

Recent structures (last update : 2010/08/25). Click each image to display the summary information, and click ID code to access PDB (Protein Data Bank) Database.

[3ALB]
ubiquitin

[3A5Y]
GenX

[3A5Z]
GenX - EF-P complex

[3ACL]
pirin

[3AFN]
A1-R

Three-dimensional structures of the TPRP proteins are retrievable here.
The up-to-date list of the TPRP proteins is downloadable here as well (Excel format).
Structure Gallery for the Protein 3000 Project (2002-2006, the predecessor of the Targeted Proteins Research Program (TPRP)) is found here.

A paralog of lysyl-tRNA synthetase
(RIKEN / Shigeyuki Yokoyama) [August 23, 2010]
Small-molecule inhibitor uncovers protein role in melanoma cell migration (RIKEN / Hiroyuki Osada) [August 16, 2010]
Biosynthesis of Mysterious 21st Amino Acid
(RIKEN / Shigeyuki Yokoyama) [August 13, 2010]
A novel nitroso-forming o-aminophenol oxidase
(University of Tokyo / Yasuo Ohnishi) [August 2, 2010]

Just Epubed section is displaying the most recent 3 Epubs from TPRP.
Official list of papers contributed from TPRP is found here.

Wheat germ cell-free protein production system for post-genomic research.

Madono M, Sawasaki T, Morishita R, Endo Y.

New Biotechnol. 2010 Aug 25.

PDBj Mine: design and implementation of relational database interface for Protein Data Bank Japan.

Kinjo AR, Yamashita R, Nakamura H.

Database (Oxford). 2010 Aug 25.

Expanding role of the Jumonji C domain as an RNA hydroxylase.

Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T.

J Biol Chem. 2010 Aug 25.

Finding Suggests New Aim for Alzheimer’s Drugs

A discovery by Paul Greengard, an 84-year-old scientist and Nobel winner, has illuminated a new direction (Nature)

Ion-pump structure linked to neurological disease

Neurological disease mutations compromise a C-terminal ion pathway in the Na+/K+-ATPase (Nature)

Bacterial charity work leads to population-wide resistance

Experiments using Escherichia coli exposed to an antibiotic show that a few drug-resistant mutants can protect the majority of the population. These resistant isolates produce the signaling molecule indole, which activates drug efflux pumps in susceptible kin (Nature)

New App Shows 2-D Structure of Thousands of RNA Molecules

Researchers used a deep-sequencing approach to determine the structure of the entire transcriptome of the yeast. The results provide interesting hints about the role of secondary structure in translation (Nature)

When It Comes to the Immune System, We're All More Alike

Researchers sequenced more than five million T-cell receptor DNA strands from each of seven healthy donors and found the strong similarity in the adaptive immune cells between different people (Science Translational Medicine)