Tanpaku News Watch (TPRP)

Tanpaku News Watch (TPRP) http://www.tanpaku.org/e_tanpaku_news_watch/ Tanpaku News Watch aggregates news relevant to TPRP from Nature (Nature Publishing Group), Science (AAAS/Science), Chemical & Engineering News (American Chemical Society), and GenomeWeb LLC.Registration (free of charge) is necessary to access GenomeWeb Daily News and Genome Technology Online of GenomeWeb LLC. en TPRP RSS Generator ver.0.9 news http://backend.userland.com/rss/ Technique Combo Beats NMR Solo http://pubs.acs.org/cen/news/88/i36/8836notw3.html Researchers have combined nuclear magnetic resonance (NMR) with X-ray and neutron scattering to solve the largest protein solution structures to date (J. Am. Chem. Soc.)<br />September 6, 2010, Chemical & Engineering News, © 2010 ACS news Mon, 06 Sep 2010 00:00:00 +0900 New Type of Anti-Malarial Compound Discovered http://www.sciencedaily.com/releases/2010/09/100902141608.htm An international team has discovered a promising new drug candidate family, spiroindolones. They obtained evidence for a decrease in drug sensitivity in strains bearing amino acid mutations in the P-type ATPase, indicating possible mechanisms of action and/or resistance (Science & J. Medicinal Chem.)<br />September 3, 2010, Science Daily, © 2010 ScienceDaily LLC news Sat, 04 Sep 2010 00:00:00 +0900 Mechanisms and Function of a Type of Mysterious Immune Cell Discovered http://www.sciencedaily.com/releases/2010/09/100902141614.htm Lymphocytes in the skin known as γδT cells provide an important barrier against infection and injury. Two studies identified a junctional adhesion molecule, JAML, as a new costimulatory receptor for γδ T cells that binds to the ligand CAR (coxsackie and adenovirus receptor) expressed on keratinocytes. The crystal structures of CAR/JAML were reported (2 papers in Science)<br />September 3, 2010, Science Daily, © 2010 ScienceDaily LLC news Sat, 04 Sep 2010 00:00:00 +0900 Molecules Involved in 'Touch' Identified: Could Lead to New Treatments for Pain, Deafness and Cardiac Function http://www.sciencedaily.com/releases/2010/09/100902151118.htm Researchers identified two ion channel proteins, Piezo1 (Fam38A) and Piezo2 (Fam38B) involved in the cellular response to mechanical stimulation (Science)<br />September 3, 2010, Science Daily, © 2010 ScienceDaily LLC news Sat, 04 Sep 2010 00:00:00 +0900 Why Fish Oils Work Swimmingly Against Inflammation and Diabetes http://www.sciencedaily.com/releases/2010/09/100902121049.htm Researchers identified a G-protein receptor GPR120 on macrophages abundantly found in obese body fat. Omega-3 fatty acids activate this macrophage receptor, resulting in broad anti-inflammatory effects (Cell)<br />September 3, 2010, Science Daily, © 2010 ScienceDaily LLC news Sat, 04 Sep 2010 00:00:00 +0900 Finding Suggests New Aim for Alzheimer’s Drugs http://www.nytimes.com/2010/09/02/health/research/02alzheimer.html?ref=health A discovery by Paul Greengard, an 84-year-old scientist and Nobel winner, has illuminated a new direction (Nature)<br />September 1, 2010, NY Times, © 2010 The New York Times Co. news Thu, 02 Sep 2010 00:00:00 +0900 Ion-pump structure linked to neurological disease http://www.nature.com/nature/journal/v467/n7311/edsumm/e100902-12.html Neurological disease mutations compromise a C-terminal ion pathway in the Na+/K+-ATPase (Nature)<br />September 2, 2010, Nature Editor's Summary, © 2010 NPG news Thu, 02 Sep 2010 00:00:00 +0900 Bacterial charity work leads to population-wide resistance http://www.nature.com/nature/journal/v467/n7311/edsumm/e100902-08.html Experiments using Escherichia coli exposed to an antibiotic show that a few drug-resistant mutants can protect the majority of the population. These resistant isolates produce the signaling molecule indole, which activates drug efflux pumps in susceptible kin (Nature)<br />September 2, 2010, Nature Editor's Summary, © 2010 NPG news Thu, 02 Sep 2010 00:00:00 +0900 New App Shows 2-D Structure of Thousands of RNA Molecules http://www.sciencedaily.com/releases/2010/09/100901132151.htm Researchers used a deep-sequencing approach to determine the structure of the entire transcriptome of the yeast. The results provide interesting hints about the role of secondary structure in translation (Nature)<br />September 1, 2010, Science Daily, © 2010 ScienceDaily LLC news Thu, 02 Sep 2010 00:00:00 +0900 When It Comes to the Immune System, We're All More Alike http://www.sciencedaily.com/releases/2010/09/100901145247.htm Researchers sequenced more than five million T-cell receptor DNA strands from each of seven healthy donors and found the strong similarity in the adaptive immune cells between different people (Science Translational Medicine)<br />September 1, 2010, Science Daily, © 2010 ScienceDaily LLC news Thu, 02 Sep 2010 00:00:00 +0900 Metal-Mining Bacteria Are Green Chemists http://www.sciencedaily.com/releases/2010/09/100901191137.htm Researchers revealed that the common soil bacterium Desulfovibrio desulfuricans recovers the precious metal palladium from industrial wastes by reducing palladium ion with its hydrogenase enzymes located on the surface membrane (Microbiology)<br />September 1, 2010, Science Daily, © 2010 ScienceDaily LLC news Thu, 02 Sep 2010 00:00:00 +0900 You give me fever http://www.natureasia.com/en/highlights/details.php?id=766 How the "fever molecule" interacts with its receptors is reported. These findings could potentially lead to the development of new anti-inflammatory treatments (Nature Immunology)<br />August 30, 2010, Nature Journal Highlights, © 2010 NPG news Tue, 31 Aug 2010 00:00:00 +0900 A new target against addiction http://www.natureasia.com/en/highlights/details.php?id=758 Inhibiting the enzyme aldehyde dehydrogenase-2 (ALDH-2) may have therapeutic potential against cocaine addiction (Nature Medicine)<br />August 23, 2010, Nature Journal Highlights, © 2010 NPG news Tue, 31 Aug 2010 00:00:00 +0900 Hydroxyurea's Revised Sickle Cell Role http://pubs.acs.org/isubscribe/journals/cen/88/i34/html/8834scic2.html Researchers determined that hydroxyurea stimulates the production of nitric oxide in red blood cells. The boost in NO increases the cells’ ability to release adenosine triphosphate, which in turn improves blood flow (Eur. J. Pharmacol.)<br />August 30, 2010, Chemical & Engineering News, © 2010 ACS news Mon, 30 Aug 2010 00:00:00 +0900 Human Adenovirus Structures http://www.sciencemag.org/content/vol329/issue5995/twis.dtl#329/5995/995-a Human adenoviruses may be a common cause of acute infections in humans, but they can also be used as vectors for vaccine and therapeutic gene transfer. Two papers described the structure of human adenovirus using complementary techniques (2 papers in Science)<br />August 27, 2010, This Week in Science, © 2010 AAAS/Science news Fri, 27 Aug 2010 00:00:00 +0900 Stress Protein Hsp12 Folds to Protect Cell Membranes Against Leaks and Ruptures http://www.sciencedaily.com/releases/2010/08/100826122607.htm Hsp12 of S. cerevisiae is upregulated several 100-fold in response to stress. Researchers revealed that normally unfolded within the yeast cell's aqueous cytosol, Hsp12 folds into helical structures to stabilize the cell membrane against heat shock and other kinds of stress (Molecular Cell)<br />August 26, 2010, Science Daily, © 2010 ScienceDaily LLC news Fri, 27 Aug 2010 00:00:00 +0900 Novel Mechanism Protects Plants Against Freezing http://www.sciencedaily.com/releases/2010/08/100826141213.htm Researchers described how a gene SENSITIVE TO FREEZING 2 (SFR2), which encodes a galactolipid remodeling enzyme, leads to the formation of a lipid that protects chloroplast and plant cell membranes from freeze damage in Arabidopsis (Science)<br />August 26, 2010, Science Daily, © 2010 ScienceDaily LLC news Fri, 27 Aug 2010 00:00:00 +0900 Advanced Melanoma: New Targeted Therapy Successful in More Than 80 Percent of Patients http://www.sciencedaily.com/releases/2010/08/100825174112.htm In more than half of all melanomas, the BRAF mutation keeps the protein constantly activated and driving cell growth. Use of an experimental targeted drug PLX4032, an inhibitor of the BRAF protein, was successful in a phase 1 clinical trial (New England Journal of Medicine)<br />August 25, 2010, Science Daily, © 2010 ScienceDaily LLC news Thu, 26 Aug 2010 00:00:00 +0900 Growing Drought-Tolerant Crops Inching Forward http://www.sciencedaily.com/releases/2010/08/100825151630.htm Pyrabactin, a synthetic chemical that mimics a key stress hormone Abscisic acid (ABA), led to the discovery of a 14-member family of ABA receptors. Researchers compared the crystal structures of multiple ABA receptors in complex with pyrabactin (2 papers in Nature Struct. Molec. Biol.)<br />August 25, 2010, Science Daily, © 2010 ScienceDaily LLC news Thu, 26 Aug 2010 00:00:00 +0900 Structure of RCC1 chromatin factor bound to the nucleosome core particle http://www.sciencedaily.com/releases/2010/08/100825131453.htm Researchers solved the crystal structures of the protein RCC1 (regulator of chromosome condensation, a protein critical for proper separation of chromosomes during cell division) bound to the nucleosome (Nature)<br />August 25, 2010, Science Daily, © 2010 ScienceDaily LLC news Thu, 26 Aug 2010 00:00:00 +0900