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• Contents
• 1. Overview
• 2. Crystal structure of multidrug transporter-antibiotics complex
• 3. Multidrug recognition by multi-site binding mode
• 4. Schematic models of AcrA-AcrB-TolC complex
• 5. "Functionally rotating mechanism" for multi-drug efflux transporter

Proposed model of the AcrA-AcrB-TolC complex. Structures of AcrA and TolC are manually docked to AcrB with inspection according to engineered cysteine cross-linking study between AcrB-TolC and AcrA-TolC.

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