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• Contents
• 1. Overview
• 2. Crystal structure of multidrug transporter-antibiotics complex
• 3. Multidrug recognition by multi-site binding mode
• 4. Schematic models of AcrA-AcrB-TolC complex
• 5. "Functionally rotating mechanism" for multi-drug efflux transporter

Close up view of the drug binding site from the cleft at the side of the trimer. Residues 274-282, 583-600, 607-614 and 623-631 are removed for a clear view of the binding site. Drug molecules and key residues for substrate binding are shown in a ball-and stick representation. Bound drug molecules are coloured as same as right top figures. Chemical bonds for drug binding are drawn as dotted lines. a. AcrB-Minocycline complex. b. AcrB-Doxorubicin complex.

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