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• Contents
• 1. Overview
• 2. Crystal structure of multidrug transporter-antibiotics complex
• 3. Multidrug recognition by multi-site binding mode
• 4. Schematic models of AcrA-AcrB-TolC complex
• 5. "Functionally rotating mechanism" for multi-drug efflux transporter

Three protomers are individually coloured (blue, red, green). (left) Ribbon representation viewed from the side parallel to the membrane plane. The minocycline molecule is shown in CPK representation, with the position of the C, N, O atoms indicated by yellow, blue and red balls, respectively. The extra-membrane (periplasmic) headpiece is at the top and the transmembrane region is at the bottom. (right) Top view of a ribbon representation.

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