WHAT'S NEW
[ 2011-08-26 ] Link to the mRNA (Homo sapiens uridine monophosphate synthetase) in NCBI is update.
[ 2011-08-25 ] Link to the protein (Homo sapiens glycerol kinase) in NCBI is update.
[ 2011-08-24 ] Links to OMIM were updated.
[ 2011-08-24 ] Links to EC numbers were updated.
[ 2011-04-06 ] Added a link to TP Atlas.
[ 2011-04-04 ] The Trypanosomes Database website was launched.
OVERVIEW
Trypanosome is a parasitic protozoan of the genus Trypanosoma that infects a variety of hosts and causes various diseases, including African sleeping sickness and South American chagas disease, that is, trypanosomiasis. Every year more than 100 thousands of people suffer from trypanosomiasis. It also infects livestock, and more than 100 thousands of cattle have died per year.
So far, we have found effective targets for drug development that can control trypanosomiasis. One of such targets is a group of enzymes that control trypanosome DNA/RNA biosynthetic pathway. Another target is a group of enzymes that control trypanosome oxidation/reduction pathway. Actually, in case of trypanosomes, these enzymes are involved in both reaction pathways, and greatly affect lives of trypanosomes.
This trypanosomes database system provides the comprehensive information for enzymes which catalyze the biosynthesis of pyrimidine and the redox reaction. The system also provides several search functions for browsing data such as keyword search, sequence search, and motif search, and several prediction tools such as protein structures and protein functions.
show descriptions on the figure

DISCLAIMER
National Institute of Genetics does not warrant or assume any legal liability or responsibility for the accuracy, completeness, or usefulness of any information available from this server.
Taxonomy icon © Database Center for Life Science licensed under CC Attribution2.1 Japan
Carbamoyl-phosphate synthetase II

predicted inhibitor
L-Glutamine
Aspartate carbamoyltransferase

predicted inhibitor
L-Glutamine
dihydroorotase

predicted inhibitor
L-Glutamine
Dihydroorotate dehydrogenase
In the de novo pyrimidine biosynthesic pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate and the reduction of fumarate to succinate. Does not use oxaloacetate and NAD or NADP as electron acceptors.
Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase

predicted inhibitor
Adenine, Adenosine monophosphate
glycerol kinase glycosomal

Alternative oxidase
T. brucei alternative oxidase
Uridine 5'-monophosphate synthase
Defects in UMPS are a cause of hereditary orotic aciduria (HOA) [MIM:258900]; also known as orotic aciduria type 1. HOA is a recessive disease characterized by retarded growth, anemia and excessive urinary excretion of orotic acid.