Research projects in the Targeted Proteins Research Program

The Targeted Proteins Research Program
field division research subject principal investigator representative organization
Investigations of fundamental biological phenomena Research
project A 		Structural and functional studies of bacterial type Ⅲ and type Ⅳ protein export systems Katsumi Imada Graduate School of Frontier Biosciences, Ｏｓａｋａ University
Structural basis for dynamic formation and mechanistic actions of huge and complicated proteolytic machinery Keiji Tanaka The Tokyo Metropolitan Institute of Medical Science,Tokyo Metropolitan Organization for Medical Research
Structural basis of Atg proteins essential for autophagy Fuyuhiko Inagaki Graduate School of Pharmaceutical Sciences, Hokkaido University
Structural biology of transcription factors and histone modification factors Yoshifumi Nishimura International Graduate School of Arts and Sciences, Yokohama City University
Structure and function of voltage-sensor domain proteins Yasushi Okamura Graduate School of Medicine, Osaka University
Structure-function analysis of protein complexes that regulate vesicular traffic Soichi Wakatsuki Institute of Materials Structure Science, High Energy Accelerator Research Organization(KEK)
Structural studies of the cell-cell junctional proteins Toshiaki Sakisaka Graduate School of Medicine, Kobe University
Research
project B		 Structural Basis of Sensor System for Cytoprotective Gene Expression Responding to Carcinogens and Oxidative Stress Masayuki Yamamoto Graduate School of Medicine, Tohoku University
Solid-state NMR investigation on functional and irregular structures of H＋─ATPsynthase Fo Hideo Akutsu Institute for Protein Research, Osaka University
3D structural and functional analyses for elucidation of the mechanism of mitochondrial respiration. Shinya Yoshikawa Graduate School of Life Science, University of Hyogo
Towards structure-based design of novel inhibitors for V ─ATPase So Iwata Graduate School of Medicine, Kyoto University
Elucidation of the mechanism of high-order cellular functions achieved by non-coding RNAs Osamu Nureki Institute of Medical Science, The University of Tokyo
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field division research subject principal investigator representative organization
Contribution to medical and pharmaceutical sciences Research
project A 		Structural analysis of molecules related to the innate immune system Shizuo Akira Immunology Frontier Research Center, Osaka University
Drug discovery-oriented analysis for structure and function of DOCK2 signaling molecules Yoshinori Fukui Medical Institute of Bioregulation, Kyushu University
Study on reactive oxygen-producing systems involved in neural cell death and structure-based discovery of their inhibitors Hideki Sumimoto Medical Institute of Bioregulation, Kyushu University
Structural analysis of γ-secretase complex for the development of the treatment for Alzheimer's disease Taisuke Tomita Graduate School of Pharmaceutical Sciences, The University of Tokyo
Development of anti-trypanosome drugs targeting nucleic acids and red-ox regulatory pathway Kiyoshi Kita Graduate School of Medical Science, The University of Tokyo
Structure-based functional analyses and development of drug intervention in metabolic syndrome and diabetes- AdipoR/AMPK/ACC as key targets Takashi Kadowaki Graduate School of Medical Science, The University of Tokyo
Research
project B		 Structural and Functional Analysis of a Molecular Target FROUNT for Drug Discovery Koji Matsushima Graduate School of Medical Science, The University of Tokyo
Development of new compounds for fibrosis therapy Junn Yanagisawa Graduate School of Life and Environmental Sciences, University of Tsukuba
Structure and drug development of NPP family members involved in cancer and
various diseases		 Jiyunken Aoki Graduate Schoo of Pharmaceutical Sciences, Tohoku University
Structural and functional analysis of semaphorins and their receptors. Atsushi Kumanogoh Research Institute for Microbial Diseases, Osaka University
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field division research subject principal investigator representative organization
Industrial applications including food and environment Research
project A 		Structural and functional analyses of signaling proteins for insect control Koji Nagata Graduate School of Agricultural and Life Sciences, The University of Tokyo
Structure-based functional analysis of key enzymes that can be applied to production of antibiotics and other useful compounds Sueharu Horinouchi Graduate School of Agricultural and Life Sciences, The University of Tokyo
Structural and functional analyses of transcriptional regulatory proteins useful for breading of drought and heat stress tolerant crops Masaru Tanokura Graduate School of Agricultural and Life Sciences, The University of Tokyo
Structural and functional analyses of regulatory proteins in plant growth and stress resistance, that is useful for improvement of the stress-resistant crop Makoto Matsuoka Bioscience and Biotechnology Center, Nagoya University
Structural biology on efflux transport machineries to understand multi-drug resistance Satoshi Murakami Graduate School of Bioscience and Biotechnology, , Tokyo Institute of Technology
Research
project B		 Structural and functional analyses of the rodent ESP family Hiroaki Terasawa Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
Structural and functional analysis of taste receptors applicable to development of new taste substances and taste evaluation systems Atsuko Yamashita Structural Physiology Research Group, Harima Institute, RIKEN
Structural biology of bacterial super-biosystem for import and degradation of polysaccharides and its application to food and environmental areas Wataru Hashimoto Graduate School of Agriculture, Kyoto University
Structural and Functional Analyses of Enzymes involved in a New Carbon Dioxide Fixation System and Their Functional Improvement Kunio Miki Graduate School of Science, Kyoto University
Structure-function analyses and improvement of useful enzymes for chiral compound prodcution Sakayu Shimizu Graduate School of Agriculture, Kyoto University
Structure and function of environmentally-responsive proteins Ko Shimamoto Graduate School of Biological Sciences, Nara Institute of Science and Technology
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Research and technological development
field division research subject principal investigator representative organization
Protein production technology Research
project C		 Development of Advanced Production Technologies for Target Proteins Shigeyuki Yokoyama Systems and Structural Biology Center, Yokohama Institute, RIKEN
Protein structural analysis technology Development of the synchrotron beamlines dedicated to the measurement of micron-size protein crystals Soichi Wakatsuki Institute of Materials Structure Science, High Energy Accelerator Research Organization(KEK)
Protein regulation technology Establishment of Chemical Library and Development of Protein Regulation Technology Tetsuo Nagano Graduate School of Pharmaceutical Sciences, The University of Tokyo
Information Platform Creation and management of information platform in Targeted Proteins Research Program Hideaki Sugawara National Institute of Genetics, Research Organization of Information and Systems
Protein production technology Research
project D		 Development of novel affinity tag system for the high-quality production of extracellular and membrane proteins. Junichi Takagi Institute for Protein Research, Osaka University
Development of innovative methods to support membrane protein crystallization Hiroaki Kato Graduate School of Pharmaceutical Sciences, Kyoto University
Antibody production for Membrane Protein Crystallisation So Iwata Graduate School of Medicine, Kyoto University
Protein structural analysis technology Structural Analysis of Membrane Protein Complexes by Solid-State NMR Toshimichi Fujiwara Institute for Protein Research, Osaka University
Diversification of protein structural analysis technologies by the SAIL method Masatsune Kainosho Graduate School of Science, Nagoya University
Information Platform Structural Bioinformatics for Modeling Protein Complex Structures Kei Yura Graduate School of Humanities and Sciences, Ochanomizu University
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